DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pod1 and Coro1a

DIOPT Version :9

Sequence 1:	NP_001245554.1	Gene:	pod1 / 31620	FlyBaseID:	FBgn0029903	Length:	1266	Species:	Drosophila melanogaster
Sequence 2:	NP_001288303.1	Gene:	Coro1a / 12721	MGIID:	1345961	Length:	461	Species:	Mus musculus

Alignment Length:	439	Identity:	155/439 - (35%)
Similarity:	231/439 - (52%)	Gaps:	39/439 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 KASKYKNAAPIVPKAEACVREICVGSYQTYGNNI-AASGAFMAFNWEHT-GSSVAVLPLDDCGRK 68
            ::||:::......||:.|..::.| |..|:.:.. |.:..|||...|.: |.:..||||...||.
Mouse     7 RSSKFRHVFGQPAKADQCYEDVRV-SQTTWDSGFCAVNPKFMALICEASGGGAFLVLPLGKTGRV 70

  Fly    69 SKTMPLLHGHTDTVTDLKFSPFHDGLLATASQDCLVKIWHIPEKGLEQSLSDPEAIFSHKQRRVE 133
            .|.:||:.|||..|.|:.:.|.:|.::|:.|:||.|.:|.||:.||...|.:|........:||.
Mouse    71 DKNVPLVCGHTAPVLDIAWCPHNDNVIASGSEDCTVMVWEIPDGGLVLPLREPVITLEGHTKRVG 135

  Fly   134 TVGFHPTADGLMYSTAAGC---VALFDLSTQKEIFS--NNEHPEVIQSASWREDGSVLATSCKDK 193
            .|.:||||..::.|  |||   :.::|:.|...:.:  .:.||:.|.|..|..||:::.|||:||
Mouse   136 IVAWHPTAQNVLLS--AGCDNVILVWDVGTGAAVLTLGPDVHPDTIYSVDWSRDGALICTSCRDK 198

  Fly   194 NVRIFDPRAAGSPIQLTAESHQSIKDSRVVWLGNQHRILTTGFDAARLRQVIIRDVRNFNTPEKT 258
            .||:.:|| .|:.:......|:..:....|:: ::.:||||||.....|||.:.|.::...|...
Mouse   199 RVRVIEPR-KGTVVAEKDRPHEGTRPVHAVFV-SEGKILTTGFSRMSERQVALWDTKHLEEPLSL 261

  Fly   259 LELDCSTGILMPLFDPDTNMLFLAGKGDTTINYLEITDKDPYL-IEGLRHTGEQTKGACLVPKRA 322
            .|||.|:|:|:|.||||||:::|.||||::|.|.|||.:.|:| ...:..:.|..:|...:|||.
Mouse   262 QELDTSSGVLLPFFDPDTNIVYLCGKGDSSIRYFEITSEAPFLHYLSMFSSKESQRGMGYMPKRG 326

  Fly   323 LKVMEAEVNRVLQLTSNMVIPIMYQVPRKTYRD-FHADLYPETTGYKTELVAGEWLNGSNQA--- 383
            |:|.:.|:.|..:|......||...||||:  | |..||||.|.|....|.|.|||.|.:..
Mouse   327 LEVNKCEIARFYKLHERKCEPIAMTVPRKS--DLFQEDLYPPTAGPDPALTAEEWLGGRDAGPLL 389

  Fly   384 -------VPKMS--------LDPAKREHGDEPIIIHRGN-LSDFVKNLE 416
                   ||..|        ||.|:|....||    .|. .||.|..||
Mouse   390 ISLKDGYVPPKSRELRVNRGLDSARRRATPEP----SGTPSSDTVSRLE 434

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pod1	NP_001245554.1	DUF1899	6..62	CDD:286094	16/57 (28%)
		WD40	<75..237	CDD:295369	56/166 (34%)
		WD40 repeat	83..127	CDD:293791	15/43 (35%)
		WD40 repeat	132..166	CDD:293791	12/36 (33%)
		WD40 repeat	174..210	CDD:293791	15/35 (43%)
		WD40 repeat	217..260	CDD:293791	12/42 (29%)
		WD40 repeat	267..294	CDD:293791	15/26 (58%)
		WD40_4	341..384	CDD:292916	20/53 (38%)
		DUF1899	808..866	CDD:286094
		WD40	843..1116	CDD:295369
		WD40 repeat	884..923	CDD:293791
		WD40 repeat	937..973	CDD:293791
		WD40 repeat	979..1016	CDD:293791
		WD40 repeat	1024..1064	CDD:293791
		WD40 repeat	1071..1094	CDD:293791
		WD40_4	1146..1189	CDD:292916
Coro1a	NP_001288303.1	WD40	9..461	CDD:392136	155/437 (35%)
		WD 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:16407068	13..63		13/50 (26%)
		WD40 repeat	37..79	CDD:293791	15/41 (37%)
		WD 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:16407068	73..110		14/36 (39%)
		WD40 repeat	85..129	CDD:293791	15/43 (35%)
		WD 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:16407068	123..160		12/38 (32%)
		WD40 repeat	134..171	CDD:293791	12/38 (32%)
		WD 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:16407068	164..204		14/39 (36%)
		WD40 repeat	180..215	CDD:293791	14/35 (40%)
		WD 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:16407068	207..251		12/44 (27%)
		WD40 repeat	223..263	CDD:293791	12/40 (30%)
		WD 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:16407068	258..296		21/37 (57%)
		WD40 repeat	270..311	CDD:293791	20/40 (50%)
		WD 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00221, ECO:0000269\|PubMed:16407068	302..349		13/46 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..434		10/34 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179930at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920