DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment pod1 and LOC100537938

DIOPT Version :9

Sequence 1:	NP_001245554.1	Gene:	pod1 / 31620	FlyBaseID:	FBgn0029903	Length:	1266	Species:	Drosophila melanogaster
Sequence 2:	XP_003201679.5	Gene:	LOC100537938 / 100537938	-ID:	-	Length:	967	Species:	Danio rerio

Alignment Length:	1270	Identity:	409/1270 - (32%)
Similarity:	592/1270 - (46%)	Gaps:	356/1270 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RFKASKYKNAAPIVPKAEACVREICVGSYQTYGNNIAASGAFMAFNWEHTGSSVAVLPLDDCGRK 68
            |||.|||||..|.:||.:..:..:..||:.:.|.:|.:|.:.:|||.:|.|..:..|...:.|..
Zfish    47 RFKTSKYKNTTPKIPKKDGWIANVRGGSFSSQGKHIKSSCSLVAFNTDHAGGGMVGLSSVNAGAD 111

  Fly    69 SK-TMPLLHGHTDTVTDLKFSPFHDGLLATASQDCLVKIWHIPEKGLEQSLSDPEAIFSHKQRRV 132
            .| ::..:..|.|.||||.||||.|.||||.|.|..||:|.:.:...:|. |:.|...|....|:
Zfish   112 GKWSVTQISCHADLVTDLDFSPFDDYLLATCSADQTVKLWRLCDVDQDQP-SNAEVTLSPADGRL 175

  Fly   133 ETVGFHPTADGLMYSTAAGCVALFDLSTQKEIFSNNEHPEVIQSASWREDGSVLATSCKDKNVRI 197
            |.:.|||.|..|:...:||.|.|:|::....:.:...|.:.:|..||:||||:||:|||||.:|:
Zfish   176 ELLLFHPAASALLAVASAGGVQLWDITRDSALTALEPHADQLQGLSWKEDGSLLASSCKDKKLRL 240

  Fly   198 FDPRAAGSPIQLTAESHQSIKDSRVVWLGNQHRILTTGFDAARLRQVIIRDVRNFNTPEKTLELD 262
            |||||..|.:| ..::||..:|||::|:.:.: :|||||:..|.::|.:.|.|...:....|.|.
Zfish   241 FDPRAQPSAVQ-CVQAHQGNRDSRILWVKDDN-LLTTGFNQVRQQEVRLWDSRKLTSSVSALSLA 303

  Fly   263 CSTGILMPLFDPDTNMLFLAGKGDTTINYLEITDKDPYLIEGLRHTGE-QTKGACLVPKRALKVM 326
            .|...|:||||.|:.:|.|:|.|::.|:..|:...:|:|.:..:...: .::|.||:||.||.:.
Zfish   304 TSNSTLIPLFDSDSGLLILSGNGESVIDCFEVNTSEPFLSQVSQCVADSSSRGVCLLPKLALDIS 368

  Fly   327 EAEVNRVLQLTSNMVIPIMYQVPRKTYRDFHADLYPETTGYKTELVAGEWLNGSNQAVPKMSLDP 391
            ..||.|::|||.|.::||.||||||..:||||||||:|.|:...:.|.||..|.|:.|.::||.|
Zfish   369 CCEVLRLMQLTENFIVPISYQVPRKAGQDFHADLYPDTVGHTAAMSADEWWKGDNKQVERVSLHP 433

  Fly   392 AKREHGDEPIIIHRGNLSDFVKNLENQRAKSNTTGKPNQQAKRNDNEHFVMLNTGNNFEEKNGND 456
            :||
Zfish   434 SKR-------------------------------------------------------------- 436

  Fly   457 NSNESNGKKSTPSQSQPDGECSELIRKFEAKYKVDSEKEKAHAYAQSHEDDKESPTEHEHSTGSS 521
                       |..:.|                  |.:|||               :.:.|.|.|
Zfish   437 -----------PKPAAP------------------SAQEKA---------------QKDLSRGKS 457

  Fly   522 EEVSSSGGLDNHSASGSHSPPKPMPRTSRSNSLPEASDSAGESSSTNTPRPRPRTTAASAYKPRL 586
            :|                                       |:||:::|...|.::|..:..|
Zfish   458 KE---------------------------------------EASSSSSPLSSPSSSAVPSRSP-- 481

  Fly   587 GPKPFSSTTGDVSFDKVFAVPLAPGSHENISNVGQDSGVEMTPAQGAKPDLIVEIEIKKKHEREP 651
                 |||:                        |..||...:|:
Zfish   482 -----SSTS------------------------GLSSGFVPSPS--------------------- 496

  Fly   652 AVSGNGVQKSLTTSERRKSSADDDESSDKIFEQNSESSENSTEGEDRTDADLRRNCTSRSSFAER 716

Zfish   497 ----------------------------------------------------------------- 496

  Fly   717 RRIYENRSKSQVDEKPQSPVPLRREHSKVEPLKPNQQQQQQGNVIDTKRISVPEGKLMEEHRRGN 781
                                             |:|
Zfish   497 ---------------------------------PSQ----------------------------- 499

  Fly   782 GAGLKKSATEAAFSAASTKRTSTVFGKVSKFRHLKGTPGHKSTHIENLRNLSRQIPGECNGFHAN 846
                            |::....:.|..|||||::|:..|:.|||.|||.|....||||:||.||
Zfish   500 ----------------SSRAIHNMLGPSSKFRHIQGSVLHRDTHITNLRGLHLTTPGECDGFCAN 548

  Fly   847 QERVAVPLSGPGGKIAIFELSRPGRLPDGVIPSLVNGSNIMDFQWDPFDAQRLAVACDDGIVKIW 911
            .|||||||:..||:||:||||:||:|||..:|::.|..|:.||.|||||..||.||.||..:::|
Zfish   549 GERVAVPLAIAGGQIAVFELSQPGKLPDTALPTIQNSVNVADFCWDPFDPHRLVVAGDDAKIRVW 613

  Fly   912 HIEAGGLSEPTNTPAGELTAHLDKIYFIRFHPLAADVLLTASYDMTIKLWDLRTMTEKCSLSGHT 976
            .|..|||.|....|...|..|.:|||.::|||.|..:|:::|||:|::||.|.|..:...||||.
Zfish   614 QIPKGGLQETLTEPECVLRGHTEKIYSVKFHPHAIGLLVSSSYDLTVRLWSLETGEQVKQLSGHQ 678

  Fly   977 DQIFDFAWSPCGRLGATVCKDGKIRVYNPRKSETPIREGNGPVGTRGARITWALEGHYIVCTGFD 1041
            ||||..||||.|:|.||||||||:|:|:||||.:||:||.||.|.||||:.|...|.:::.:|||
Zfish   679 DQIFGMAWSPDGKLLATVCKDGKVRLYDPRKSTSPIQEGPGPEGQRGARVVWVCGGKFLMVSGFD 743

  Fly  1042 KVSERQISVYNAQKL-SAPLNTASLDVSPSILIPFYDEDSSTLFVTGKGDSTIYCYEITDEEPYI 1105
            ..||||:.:::|:.| |..|.:|..|||||.||||||.|:|.|.:|||||:.:|.|||..|.||.
Zfish   744 SRSERQLYLFSAESLASGSLASAPADVSPSTLIPFYDPDTSVLILTGKGDTRVYIYEIVPEAPYF 808

  Fly  1106 CPLSHHRCTSLHQGLSFLTKNHCDVASVEFSKAYRLTNTTIEPLSFTVPRIKSELFQDDLFPPTR 1170
            ...|....:..|:||.||.|..|||..||.::|.||..|||||::|.|||:|.|.||||:||.|.
Zfish   809 MECSSFNSSEPHKGLCFLPKTECDVRDVEVARAVRLGKTTIEPVAFRVPRVKKEFFQDDVFPDTA 873

  Fly  1171 ITWSATLSSEDWFASNDKAAPKVSLKPEGMETLSSIQQVPAQ-PVKK--PDHPQFGGQKSEYEIN 1232
            :.|.::||:.:|.:.:|....|:||:|:.|   :.:.:.|.: ||:|  |.......:..|   .
Zfish   874 VWWESSLSAAEWLSGSDGQHRKISLRPKDM---TPVSEAPKEAPVRKYLPSSVYLEEKTDE---Q 932

  Fly  1233 KQQEIQKSVSARM-EFTTKLEQDDMEGVDENEWQE 1266
            |::|:..::.|:: .....|.|:..|||||:||.:
Zfish   933 KKEELLSAMVAKLGNREDPLPQESYEGVDEDEWDD 967

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
pod1	NP_001245554.1	DUF1899	6..62	CDD:286094	20/55 (36%)
		WD40	<75..237	CDD:295369	69/161 (43%)
		WD40 repeat	83..127	CDD:293791	20/43 (47%)
		WD40 repeat	132..166	CDD:293791	11/33 (33%)
		WD40 repeat	174..210	CDD:293791	22/35 (63%)
		WD40 repeat	217..260	CDD:293791	13/42 (31%)
		WD40 repeat	267..294	CDD:293791	11/26 (42%)
		WD40_4	341..384	CDD:292916	23/42 (55%)
		DUF1899	808..866	CDD:286094	34/57 (60%)
		WD40	843..1116	CDD:295369	144/273 (53%)
		WD40 repeat	884..923	CDD:293791	20/38 (53%)
		WD40 repeat	937..973	CDD:293791	14/35 (40%)
		WD40 repeat	979..1016	CDD:293791	25/36 (69%)
		WD40 repeat	1024..1064	CDD:293791	15/40 (38%)
		WD40 repeat	1071..1094	CDD:293791	14/22 (64%)
		WD40_4	1146..1189	CDD:292916	21/42 (50%)
LOC100537938	XP_003201679.5	DUF1899	47..99	CDD:312494	21/51 (41%)
		WD40 repeat	86..121	CDD:293791	8/34 (24%)
		WD40_4	126..460	CDD:330497	142/481 (30%)
		WD40 repeat	127..170	CDD:293791	20/43 (47%)
		WD40 repeat	175..211	CDD:293791	11/35 (31%)
		WD40 repeat	218..254	CDD:293791	22/36 (61%)
		WD40 repeat	261..301	CDD:293791	13/40 (33%)
		WD40 repeat	309..349	CDD:293791	14/39 (36%)
		WD40_4	512..>898	CDD:330497	201/385 (52%)
		WD40 repeat	545..583	CDD:293791	24/37 (65%)
		WD40 repeat	589..633	CDD:293791	21/43 (49%)
		WD40 repeat	638..675	CDD:293791	15/36 (42%)
		WD40 repeat	682..718	CDD:293791	24/35 (69%)
		WD40 repeat	762..815	CDD:293791	29/52 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	145	1.000	Domainoid score	I4526
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D179930at33208
OrthoFinder	1	1.000	-	-		FOG0004080
OrthoInspector	1	1.000	-	-		otm24266
orthoMCL	1	0.900	-	-		OOG6_105739
Panther	1	1.100	-	-	O	PTHR10856
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X4043
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	8	7.920