DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment C3G and RAPGEF2

DIOPT Version :9

Sequence 1:NP_572350.2 Gene:C3G / 31618 FlyBaseID:FBgn0259228 Length:1571 Species:Drosophila melanogaster
Sequence 2:XP_005263415.1 Gene:RAPGEF2 / 9693 HGNCID:16854 Length:1701 Species:Homo sapiens


Alignment Length:1199 Identity:237/1199 - (19%)
Similarity:410/1199 - (34%) Gaps:371/1199 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   465 IMGAVTASPGASVPGTGVMRVSAAESAAQRTSLPDIALTPKERDILEQHNVN----PMRGSH--- 522
            :.|:|.......:|.:...:.||   .:.|.....|.|.|.|..:::..:.|    ..:.||   
Human    78 LSGSVFIKESMFLPRSSFGKRSA---GSFRRGCECIVLEPSEMIVVDYMDENEEYFQRQASHRQS 139

  Fly   523 -----------STESILRDTSPPP--KPPLP-------NRASNP---------PPLPPKRRSQPS 558
                       ..::|:....|.|  |||||       .::..|         ..|.|:.....|
Human   140 RRRFRKINQKGERQTIIDTVDPYPMGKPPLPRGYHTECTKSQLPADFTKLHLTDSLHPQVTHVSS 204

  Fly   559 ASAGTVGVGCS-SSTSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRLSVRSRSPD--E 620
            :.:     ||| :|.|.|:..|.:..|..   |...|:|.|        |:...:|.|...|  |
Human   205 SHS-----GCSITSDSGSSSLSDIYQATE---SEAGDMDLS--------GLPETAVDSEDDDDEE 253

  Fly   621 NSQCSFDSALNH------------SREEEDQQQQHQHLRSFPKLAAM------------------ 655
            :.:.:.|..::.            .|.::|.:|..:.:...|..|.|                  
Human   254 DIERASDPLMSRDIVRDCLEKDPIDRTDDDIEQLLEFMHQLPAFANMTMSVRRELCAVMVFAVVE 318

  Fly   656 -----MDEDMDKMVSYSAAIDDKTQTPLSTGGGIAGVAGGTGGAG--------EGVAAAASGDGE 707
                 :..|.:::.|:|..::...:.....|.......|.:.|..        :||......|.:
Human   319 RAGTIVLNDGEELDSWSVILNGSVEVTYPDGKAEILCMGNSFGVSPTMDKEYMKGVMRTKVDDCQ 383

  Fly   708 TNSNRHSNESGFVSMREFRTSTQTTDY-----SVQSSTKSSSSNSEIAFSISESTAVGSSSEYQQ 767
                       ||.:.:       .||     .|:.:.:......||..          ..|:::
Human   384 -----------FVCIAQ-------QDYCRILNQVEKNMQKVEEEGEIVM----------VKEHRE 420

  Fly   768 ISQLVSHSQRHISSSSSSCTTTTTSSSTTTGY----GSSEVEQLQQQQQQQTTTTPADLAPALPP 828
            :.:                      :.|..|:    |:||          :.|....:....:.|
Human   421 LDR----------------------TGTRKGHIVIKGTSE----------RLTMHLVEEHSVVDP 453

  Fly   829 KSIQRSSLTRH---DSP-GVGDELDEVQSSSGWASHRSSQSEVAELRQLSPLHHLN-HHPHTASA 888
            ..|:...||..   .|| .||.:|.|      |.:..|.:.:|..:..|...:|.| .....|..
Human   454 TFIEDFLLTYRTFLSSPMEVGKKLLE------WFNDPSLRDKVTRVVLLWVNNHFNDFEGDPAMT 512

  Fly   889 GQLQQWHSKHHSLIEGPRLQLAGSGSCSAFDQRHL-----DQEPPPLPI-----KKKHILAYMEI 943
            ..|:::.:.......|..|:|... :|:|..:|.|     .....|||.     .:|....:::.
Human   513 RFLEEFENNLEREKMGGHLRLLNI-ACAAKAKRRLMTLTKPSREAPLPFILLGGSEKGFGIFVDS 576

  Fly   944 CSASTRSIE-----------------QHRHTMHACNISRNISH-SQTM--NIMPMSKELSPELEM 988
            ..:.:::.|                 ::.....|..|.||.:| |.|:  |:. :.|||...|..
Human   577 VDSGSKATEAGLKRGDQILEVNGQNFENIQLSKAMEILRNNTHLSITVKTNLF-VFKELLTRLSE 640

  Fly   989 -----PPALPPKNYKQRKATSMVASPTL----QPVI--VTTPPPSPKPTLGENGSTGRPDSRMAT 1042
                 .|.||  .....|..|..:.|.|    :.||  ......|...|:|     ||  :::..
Human   641 EKRNGAPHLP--KIGDIKKASRYSIPDLAVDVEQVIGLEKVNKKSKANTVG-----GR--NKLKK 696

  Fly  1043 VCEELNDAVASEDAMPEPRSPVLDSNENVSAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPIT 1107
            :.::...::.       |:.|..|.....|. ||.......:..:|.| :.:|...||::     
Human   697 ILDKTRISIL-------PQKPYNDIGIGQSQ-DDSIVGLRQTKHIPTA-LPVSGTLSSSN----- 747

  Fly  1108 TPQVLEEQEEPTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDGP 1172
             |.:|:.              |..:    :|.....:..|.::.:.:....:||:::.|      
Human   748 -PDLLQS--------------HHRI----LDFSATPDLPDQVLRVFKADQQSRYIMISK------ 787

  Fly  1173 EVKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAA 1237
                                 |....|..|...|.|     .:.....:|:  .|:|....:...
Human   788 ---------------------DTTAKEVVIQAIREF-----AVTATPDQYS--LCEVSVTPEGVI 824

  Fly  1238 KETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGF 1302
            |:                  .:|...|.:...::..||:.|    |:|. :|..||..:......
Human   825 KQ------------------RRLPDQLSKLADRIQLSGRYY----LKNN-METETLCSDEDAQEL 866

  Fly  1303 VGELGGAGSVGGAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVL--- 1364
            :.|                         :|.|||.|.::|:|.|:::.:.|||..||..|.:   
Human   867 LRE-------------------------SQISLLQLSTVEVATQLSMRNFELFRNIEPTEYIDDL 906

  Fly  1365 --LFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNS 1427
              |.:|..|    .||.:|.|..|:.::|..|:|||..:..:|.|.:..||||..|.|:..|:||
Human   907 FKLRSKTSC----ANLKRFEEVINQETFWVASEILRETNQLKRMKIIKHFIKIALHCRECKNFNS 967

  Fly  1428 YLALLSALDSGPIRRLE--WQK------GITEEVRSFCALIDSSSSFRAYRQALAETN--PPCIP 1482
            ..|::|.|:..|:.||.  |:|      .:.::::.   |.|.|.:...||..|...|  ||.||
Human   968 MFAIISGLNLAPVARLRTTWEKLPNKYEKLFQDLQD---LFDPSRNMAKYRNVLNSQNLQPPIIP 1029

  Fly  1483 YIGLILQDLTFVHVGNQDYLSKGVINFSK 1511
            ...:|.:||||:|.|| |....|::||.|
Human  1030 LFPVIKKDLTFLHEGN-DSKVDGLVNFEK 1057

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C3GNP_572350.2 RasGEFN 1170..1306 CDD:214571 19/135 (14%)
RasGEF 1335..1558 CDD:238087 68/192 (35%)
RAPGEF2XP_005263415.1 CAP_ED 37..143 CDD:237999 13/67 (19%)
cNMP 297..412 CDD:197516 16/132 (12%)
RasGEFN 428..541 CDD:214571 27/129 (21%)
PDZ_signaling 545..625 CDD:238492 13/79 (16%)
degP_htrA_DO <565..689 CDD:273938 25/126 (20%)
RA_PDZ-GEF1 769..851 CDD:340483 18/137 (13%)
RasGEF 874..1099 CDD:238087 68/192 (35%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.940

Return to query results.
Submit another query.