DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C3G and Sos2

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001129033.1	Gene:	Sos2 / 85384	RGDID:	620435	Length:	1333	Species:	Rattus norvegicus

Alignment Length:	525	Identity:	127/525 - (24%)
Similarity:	223/525 - (42%)	Gaps:	124/525 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly  1113 EEQEEPTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDG-PEVKG 1176
            ||.|:|....||  .|:..|    |.:.||        |::.|.|:        :...| |.:||
  Rat   560 EENEQPLRLPRP--DVYRFV----VTDSEE--------NIVFEDNL--------QSRSGIPIIKG 602

  Fly  1177 GYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETF 1241
            |.:..||...: ....||..|...|:||:|:|.:|.:::..|..|:     ::.|.:...|.:
  Rat   603 GTVVKLIERLT-YHMYADPNFVRTFLTTYRSFCKPQELLSLLIERF-----EIPDPEPTEADK-- 659

  Fly  1242 ALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTL--------YKEPK 1298
             |.:.......|.||                        |..|.::|:.|.|        :.|..
  Rat   660 -LALEKGEQPISADL------------------------KRFRKEYVQPVQLRVLNVFRHWVEHH 699

  Fly  1299 VYGFVGEL-------GGAGSVGGAGI----------------AGSGGCS---------------- 1324
            .|.|..:|       ....||.|..:                |.:.|.|
  Rat   700 FYDFERDLELLERLEAFISSVRGKAMKKWVESIAKIIKRKKQAQANGVSHNITFESPPPPVEWHI 764

  Fly  1325 GTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVL--LFAKDQCEEKSPNLNKFTEHFNK 1387
            ..||......|:.|..:|||.|:|||:::|:.:::..|::  ::.|:..|..||||.|...|...
  Rat   765 SRAGQSETFDLMTLHPIEIARQLTLLESDLYRRVQPSELVGSVWTKEDKEINSPNLLKMIRHTTN 829

  Fly  1388 MSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLEWQ-KGITE 1451
            ::.|....|:..::.:||...:::.::|::..:.:||:|..|.::||::|..:.||:.. :.:.|
  Rat   830 LTLWFEKCIVEAENFEERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQE 894

  Fly  1452 EVRSFCALID-----SSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYL---SKGVIN 1508
            ..|   .::|     |...|:.|...|...||||:|:.|:.|.::.....||.|:|   .|.:||
  Rat   895 RKR---RVLDDAVELSQDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLIN 956

  Fly  1509 FSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFK--DFMGEEE----MWQISEKIKPRG-R 1566
            ||||.:...|...:::::...|..|....:.|||:|..  ..:.|:|    ::..|.:|:||. :
  Rat   957 FSKRRKVAEITGEIQQYQNQPYCLRTEPEMRRFFENLNPMGLLSEKEFTDYLFNKSHEIEPRNCK 1021

  Fly  1567 RPVNY 1571
            :|..:
  Rat  1022 QPPRF 1026

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	32/144 (22%)
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	67/239 (28%)
Sos2	NP_001129033.1	Histone	60..169	CDD:278551
		H2A	97..>147	CDD:305064
		RhoGEF	200..387	CDD:238091
		PH_SOS	438..544	CDD:269963
		PH	444..545	CDD:278594
		RasGEFN	596..740	CDD:214571	36/176 (20%)
		RasGEF	775..1019	CDD:214539	70/246 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810