DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment C3G and LTE1

DIOPT Version :9

Sequence 1:NP_572350.2 Gene:C3G / 31618 FlyBaseID:FBgn0259228 Length:1571 Species:Drosophila melanogaster
Sequence 2:NP_009378.1 Gene:LTE1 / 851209 SGDID:S000000022 Length:1435 Species:Saccharomyces cerevisiae


Alignment Length:1454 Identity:274/1454 - (18%)
Similarity:504/1454 - (34%) Gaps:411/1454 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   260 HKNSLKGTKLARRAR------SFKDDLIEKISLMRTTN-----NTLGRSHSPHSPRTKHGTKAPP 313
            ||   :|::|:..||      .|::..:  :||.:|::     ..|..|:|..:.|:......|.
Yeast   196 HK---RGSRLSIYARQSFASPDFRNQSV--LSLYKTSDVFRLPEKLQSSNSSKNQRSPSMLLFPD 255

  Fly   314 TTEEV-----LRSTQTLETHVKDISNA---LKHFRDVILKKKL-------------EVLPG---- 353
            .|..|     :....:::...:|:|::   :.|...|.|...|             :::|.    
Yeast   256 NTSNVYSKHRIAKEPSVDNESEDMSDSKQKISHLSKVTLVSTLMKGVDYPSSYAVDKIMPPTPAK 320

  Fly   354 ------NGTVILETIASMYSVIQ----TYTL----NENSAIMSSATLQVYQS----LGKLIKLCD 400
                  |...|.|.:......:|    |.:|    |.||...:|:...:::|    |.|.:|..:
Yeast   321 KVEFILNSLYIPEDLNEQSGTLQGTSTTSSLDNNSNSNSRSNTSSMSVLHRSAIGLLAKWMKNHN 385

  Fly   401 EVMLSEDSGECASLSNENVREVIDLLEDAVRNLVTLAQGKLKEQDQCAFRYSGSGLGGIGAAAEI 465
            ....|.|....:::...|.:..:|.....|.::.:|.:...||::: .|..|.|      :..:|
Yeast   386 RHDSSNDKKFMSAIKPANQKPEMDAFVKYVVSISSLNRKSSKEEEE-EFLNSDS------SKFDI 443

  Fly   466 MGAVTASPGASVPGTGVMRVSAAESAAQRTSLPDIALTPKERD------ILEQHNVNPMRGSHS- 523
            :.|.|.....|:.......:...::.:.....|.:.:..:.|:      ||:|::..|...:.| 
Yeast   444 LSARTIDEVESLLHLQNQLIEKVQTHSNNNRGPTVNVDCERREHIHDIKILQQNSFKPSNDNFSA 508

  Fly   524 -------------TESILRDTSPPPKPPLPNRASNPPPLPP----KRRSQPSASAGTVGVGCSSS 571
                         .:|::..|:...| .|.|..||..|.|.    :||...|.           :
Yeast   509 MDNLDLYQTVSSIAQSVISLTNTLNK-QLQNNESNMQPSPSYDALQRRKVKSL-----------T 561

  Fly   572 TSTSNQASPLPYAQSHNISLNSDLDCSSNISLLNYGVDRLSVRSRSPDENSQCSFDSALNHSREE 636
            |:..|:......|:|..:   .|.|.||:.:..| |..||...     |..:.:.::..|.:...
Yeast   562 TAYYNKMHGSYSAESMRL---FDKDNSSSRTDEN-GPQRLLFH-----ETDKTNSEAITNMTPRR 617

  Fly   637 EDQQQQHQHLRSFPKLAAMMD-----------EDMDKMV-SYSAAIDDKT---QTPLSTGGGIAG 686
            ::..|..:.:.|.|....:.|           ||.:.:. ||.:.:...:   .|.......:..
Yeast   618 KNHSQSQKSMTSSPLKNVLPDLKESSPLNDSREDTESITYSYDSELSSSSPPRDTVTKKSRKVRN 682

  Fly   687 VAGGTGGAGEGVAAAASGDGETNSNRHSNESGFVSMREFRTSTQTTDYSVQSST----KSSSSNS 747
            :.                 ..|:|.....::||:::||| |...|.....:.||    :.:..|.
Yeast   683 IV-----------------NNTDSPTLKTKTGFLNLREF-TFEDTKSLDEKKSTIDGLEKNYDNK 729

  Fly   748 EIAFSISEST-----AVGSSSEYQQISQLVSHSQRHISSSSSSCTTTTTSSSTTTGYGSSEVEQL 807
            |...|..|||     ::.:|||.....  ::..::|     |||......:......|...:.::
Yeast   730 ENQESEYESTKKLDNSLDASSEANNYD--ITTRKKH-----SSCNHKIKQAVVRPASGRISISRV 787

  Fly   808 QQQQQQQTTTTPADLAPALPPKSIQRSSLTRHDSPGVGDELDEVQ-------SSSGWASHRS--- 862
                 |....||......:.|:        ::.|..|.:|:.|::       ..|...|..|   
Yeast   788 -----QSIAITPTKELSIVDPE--------QNKSNSVIEEISEIEPLNLEYNKKSALYSDTSSTV 839

  Fly   863 ---SQSEVAELRQLSPLHHLNH----HPHTASAGQLQQWHSKHHSLIEGPRLQLAGSGSCSAFDQ 920
               |.|::.|..|.|||....:    .|:..|..:..:........||.....|....:.|..:.
Yeast   840 ISISTSKLFESAQNSPLKQTQNPQREFPNGTSVSETNRIRLSIAPTIESVVSDLNSITTGSTVET 904

  Fly   921 RHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHRHTMHACNISRNISHSQTMNIMPMSKELSPE 985
            ....::   ||:..:.|:...|......:.|..:..::|         ..:|:::...:.:|.  
Yeast   905 FETSRD---LPVPHQRIINLREEYQRGNQDIISNTSSLH---------ELKTIDLSDSNNDLE-- 955

  Fly   986 LEMPPALPPKNYKQRKATSMVASPTLQPVIVTTPPPSPKPTLGENGSTGRPDSRMATVCEELNDA 1050
               .|:...||.|      ...||....:.|.:|                    |..| |||...
Yeast   956 ---SPSTHAKNNK------YFFSPDDGSIDVASP--------------------MKNV-EELKSK 990

  Fly  1051 VASEDAMPEPRSPVLDSNENVS----AVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPITTPQV 1111
            ....::         ::|.|:|    .:||               :::: |.|||.|        
Yeast   991 FLKNES---------ETNSNISGSVLTMDD---------------IDIN-DTSSARN-------- 1022

  Fly  1112 LEEQEEPTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYLI-LKKREEDGPE-- 1173
                   |..:....|...|:...|::     |.|:||.:.:.:..||..|: |:...|..||  
Yeast  1023 -------TRRANSESAFTGSLNKKNLN-----EIANMLDDSINDDPITVALMKLEGTYEKIPEKP 1075

  Fly  1174 --VKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKA 1236
              .|..  ||:.:..|   |:||.                   :|.|.......|......|:| 
Yeast  1076 ENTKSS--DAIGIKTS---KLADE-------------------VEMLNLNNLPSFQNSPAEKRK- 1115

  Fly  1237 AKETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFV----EKVTLYKEP 1297
                                     |||:|...|.:.:......:..:..|.    ||:.:....
Yeast  1116 -------------------------SLLIERRRQTIMNIPFTPDQSEKEGFTSSSPEKIDVSANV 1155

  Fly  1298 KV---YGFVGELGGAGSVGGAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKI- 1358
            .|   ...:.||.|...:..:.:..|...|      :.|.:|...||.:|:||||::.|:..:| 
Yeast  1156 DVAVQAAQIQELIGQYRIHDSRLMISNNES------HVPFILMYDSLSVAQQMTLIEKEILGEID 1214

  Fly  1359 -----------EIPEVL----LFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKH 1408
                       |.|:|:    |..::   |....::.....||....|..|:||..:.:|.:...
Yeast  1215 WKDLLDLKMKHEGPQVISWLQLLVRN---ETLSGIDLAISRFNLTVDWIISEILLTKSSKMKRNV 1276

  Fly  1409 VNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRR-------------LEWQKGITEEVRSFCALI 1460
            :.:||.:..|.|...|:|:.:.::.||.|..:::             |.|     ||::...:| 
Yeast  1277 IQRFIHVADHCRTFQNFNTLMEIILALSSSVVQKFTDAWRLIEPGDLLTW-----EELKKIPSL- 1335

  Fly  1461 DSSSSFRAYRQALAETNP--PCIPYIGLILQDLTFVHVGNQDY-LSKGVINFSK----------- 1511
              ..::...|..|...||  .|:|:|.:.|.||: .:...:|: |...|:|::|           
Yeast  1336 --DRNYSTIRNLLNSVNPLVGCVPFIVVYLSDLS-ANAEKKDWILEDKVVNYNKFDTNVQIVKNF 1397

  Fly  1512 ----RWQQ-YNIIDNMKRFKKCAY 1530
                :|.: |....|.:...||.|
Yeast  1398 IQRVQWSKFYTFKVNHELLSKCVY 1421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C3GNP_572350.2 RasGEFN 1170..1306 CDD:214571 23/146 (16%)
RasGEF 1335..1558 CDD:238087 57/244 (23%)
LTE1NP_009378.1 RasGEFN 28..156 CDD:214571
RasGEF 1190..1434 CDD:238087 57/244 (23%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR23113
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
43.940

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