DRSC/TRiP Functional Genomics Resources

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Protein Alignment C3G and Ralgps2

DIOPT Version :9

Sequence 1:NP_572350.2 Gene:C3G / 31618 FlyBaseID:FBgn0259228 Length:1571 Species:Drosophila melanogaster
Sequence 2:NP_001153437.1 Gene:Ralgps2 / 78255 MGIID:1925505 Length:590 Species:Mus musculus


Alignment Length:248 Identity:73/248 - (29%)
Similarity:126/248 - (50%) Gaps:29/248 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly  1342 EIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKS--PNLNKFTEHFNKMSYWARSKILRLQDAKE 1404
            |.|.|:||:|..:|..|:..|:.....::.|:.|  ||...||..||.:|:|...:||..|..|.
Mouse    52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKI 116

  Fly  1405 REKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRL--EW------QKGITEEVRSFCALID 1461
            |.:.::.:||..|.|.::||.::.:|::|.|.|.||.||  .|      .|...|::....:..|
Mouse   117 RAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKED 181

  Fly  1462 SSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRF- 1525
            :....|.|..:|..|  |||||:|:.|.|||::   :..|.|.|.|  .:..|:.|:::|:.|. 
Mouse   182 NYKRLRDYISSLKMT--PCIPYLGIYLSDLTYI---DSAYPSTGSI--LENEQRSNLMNNILRII 239

  Fly  1526 ----KKCAYPF------RRNERIIRFFDNFKDFMGEEEMWQISEKIKPRGRRP 1568
                :.|.|..      ::....:::.:..:.|: |::.:::|.||:|....|
Mouse   240 SDLQQSCEYDIPILPHVQKYLNSVQYIEELQKFV-EDDNYKLSLKIEPGASTP 291

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C3GNP_572350.2 RasGEFN 1170..1306 CDD:214571
RasGEF 1335..1558 CDD:238087 68/236 (29%)
Ralgps2NP_001153437.1 RasGEF 45..286 CDD:214539 71/241 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 288..319 1/4 (25%)
PXXP 331..334
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..413
Required for stimulation of nucleotide exchange by RALA. /evidence=ECO:0000250 466..590
PH_RalGPS1_2 466..581 CDD:270120
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
21.810

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