Protein Alignment C3G and rapgef1

DIOPT Version :9

• Sequence 1: NP_572350.2
• Gene: C3G / 31618
• FlyBaseID: FBgn0259228
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: XP_031746374.1
• Gene: rapgef1 / 733953
• XenbaseID: XB-GENE-5729483
• Length: 1173
• Species: Xenopus tropicalis
• Alignment Length: 1403
• Identity: 457/1403 - (32%)
• Similarity: 634/1403 - (45%)
• Gaps: 366/1403 - (26%)

  Fly   281 IEKISLMRT-----TNNTLGRSHSPHSPRT--KHGTKAPPT--TEE--VLRSTQTLETHVKDISN 334
            |||....|:     |.....:.|||...||  |.|..|..|  |||  |.::...||...|::.|
 Frog     5 IEKADSQRSHLSSFTMKLKDKFHSPKIKRTPSKKGKPADLTVKTEEKPVNKTLSRLEEQEKEVVN 69

  Fly   335 ALKHFRDVILKKKLE-----VLPGNGTVILETIASMYSVIQTYTLNENSAIMSSATLQVYQSLGK 394
            ||::|:.::.|..::     :|||:.:.:||.|..:   :|..|..:.|..:||...:|||||..
 Frog    70 ALRYFKTIVDKMAVDKMVLVMLPGSASKVLEAILPL---VQVDTRCQESTAISSCYSRVYQSLAN 131

  Fly   395 LIKLCDEVML----SEDSGECASLSNENVREVIDLLEDAVRNLVTLAQGKLKEQDQCAFRYSGSG 455
            ||:..|:|||    |||.....:     |::||..:.|.|:.||.|   .:::|:..:
 Frog   132 LIRWSDQVMLEGVNSEDKEMVTT-----VKDVIKAVLDGVKELVRL---MIEKQEHPS------- 181

  Fly   456 LGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESAAQRTSLPDIALTPKERDILEQHNVNPMRG 520
                       ...|..|  |:|            |::..|..::.|:.:|.:||.: ...|...
 Frog   182 -----------PTTTVKP--SLP------------ASKTDSTTELPLSERELEILNK-TPEPTSK 220

  Fly   521 SHSTESILRDTSPPPKPPLPN----RASNPPPLPPKRRSQPSASAGTVGVGCSSSTSTSNQASPL 581
            ....:|:..:...|||||||.    ..|.||.||||:| |.:.|...|.|....|.:||..:.|
 Frog   221 EAQVDSLESEELAPPKPPLPGIRVMDNSPPPALPPKKR-QSAPSPTRVAVVAPMSRATSGSSLP- 283

  Fly   582 PYAQSHNISLNS---DLDCSSNISLLNYGVDRLSVRSRS----PDENSQCSFDSALNHSREEEDQ 639
                   |.:|:   :.||        |...|||..|:|    ....|.||....|:.|.|:
 Frog   284 -------IGINNQDFEGDC--------YVRRRLSGGSQSYGGESPRLSPCSSIGKLSKSDEQ--- 330

  Fly   640 QQQHQHLRSFPKLAAMMDEDMDKMVSYSAAIDDKTQTPLSTGGGIAGVAGGTGGAGEGVAAAASG 704
                         .:.:|.|
 Frog   331 -------------LSSLDRD--------------------------------------------- 337

  Fly   705 DGETNSNRHSNESGFVSMREFRTSTQTTD-YSVQ--------SSTKSSSSNSEIAFSISESTAVG 760
            .|:.:.|               ||.:|.| |...        |.|.....:..|...:.||  :.
 Frog   338 SGQCSRN---------------TSCETLDNYDPDYEFLQEDLSRTDQVPGHGTILSPLPES--LE 385

  Fly   761 SSSEYQ-QISQLVSHSQRHISSSSSSCTTTTTSSSTTTGYGSSEVEQLQQQQQQQTTTTPADLAP 824
            |:|.:| |..|:                    .:..|.....|.||            ||    |
 Frog   386 SASPFQGQSFQM--------------------PAGDTPNSEHSAVE------------TP----P 414

  Fly   825 ALPPKSIQRSSLTRHDSPGVGDELDEVQSSSGWASHRSSQSEVAELRQLSPLHHLNHHPHTASAG 889
            |||.|.      .|..:|...|.:     ...:..|.|....:.| ..|||.......|. |:..
 Frog   415 ALPQKK------RRSTAPQTSDSI-----RGCYERHPSQYDNLCE-DDLSPFVSAAMPPF-AAVS 466

  Fly   890 QLQQWHSKHHSLIEGPRLQLAGSGSCSAF-------DQRHLDQEPPPLPIKK-KHILAYM---EI 943
            ..||                 ||.|.:.|       :...:.:.|||||.|| ||::.||   |.
 Frog   467 PFQQ-----------------GSPSQAEFLLDFVAAESDGIPENPPPLPEKKNKHMMTYMRFVED 514

  Fly   944 CSASTRSI----EQHRHTMHACNISRNISHSQTMNIMPMSKELSPELEMPPALPPKNYKQRKATS 1004
            .|....|:    .|:.|.....|  :::......|....|.|...|...||||||   |||:...
 Frog   515 YSEPQPSVFYQTPQNEHIYQQKN--KHLREVYGFNDSFSSPESGHERAPPPALPP---KQRQMQG 574

  Fly  1005 MVASPTLQPVI--------VTTPPPSPKPT----------LGENGSTGRP--------------- 1036
            ..|:.:...|.        |..|..:..|.          |..:||...|
 Frog   575 SFAASSFSSVSYCAQTTKGVFPPEDTSHPQGISLSVSNCFLSRHGSFPVPSYKSVFRSYSQDFAP 639

  Fly  1037 --------------DSRMATVCEELNDAVASEDAMPE-PRSPVLDSNENVSAVDDGQTFYCHSHQ 1086
                          .||.:.|   |:|:.:|..|||: |..|.|..::..|:.....|...:...
 Frog   640 HNQAPPLLAPAIFYSSRFSPV---LSDSASSPPAMPQVPLRPPLPPSQGGSSCGTPPTCLAYEPS 701

  Fly  1087 LPAAEMEMSEDA---SSADNQPITTPQVLEEQEEPTAESRPLVAVHESVKPANVD-------EDE 1141
            | :..::.|.|:   :....|..|.| .|..::...|..||         |.:.|       |.|
 Frog   702 L-SGTLQTSADSPLPNEGPQQNCTLP-CLPGKDNHEASERP---------PKSPDCHSDENGEGE 755

  Fly  1142 EAERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHASRVQKVADNAFCEAFITTFR 1206
            |.|..|.| ::::...|...|.||:..:|||:|:||..|.|:|||:...:.....:.|||:||:|
 Frog   756 EEEELDEL-SLVDHNEIMAKLTLKQEGDDGPDVRGGSGDILLVHATETDRKDLVLYFEAFLTTYR 819

  Fly  1207 TFIQPIDVIEKLTHRYTYFFCQVQDN-KQKAAKETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQ 1270
            |||.|.::|:||.:||.. ||..||. ||:.:|.||.:|||||::|...::|.::|.||:|.|::
 Frog   820 TFITPEELIQKLQYRYER-FCHFQDTFKQRVSKNTFFVLVRVVDELCLVEMTDEILKLLMELVFR 883

  Fly  1271 LVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGFVGELGGAGS----VGGAGIAGSGGCSGTAGGGN 1331
            |||.|:|.||::||...:|||    |.|     ..|..|.|    :...|:|...|
 Frog   884 LVCKGELSLARILRKNILEKV----ENK-----RMLHHANSALKPLAARGVAARPG--------- 930

  Fly  1332 QPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKI 1396
              :|.|..|||||||:||||||||.|||||||||:||:|.|||||||.:||||||.||||.||.|
 Frog   931 --TLHDFHSLEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSII 993

  Fly  1397 LRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLEWQKGITEEVRSFCALID 1461
            :..:.|::||:.:.|||||||||||:||:|||||:||||||.|||||||||..:|.:..:|.|||
 Frog   994 MLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRLEWQKQTSEGLAEYCTLID 1058

  Fly  1462 SSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFK 1526
            |||||||||.||||..||||||:|||||||||||:||.|::. |.:||||||||:||:|:|:||:
 Frog  1059 SSSSFRAYRAALAEVEPPCIPYLGLILQDLTFVHLGNPDHID-GKVNFSKRWQQFNILDSMRRFQ 1122

  Fly  1527 KCAYPFRRNERIIRFFDNFKDFMGEEEMWQISEKIKPR 1564
            :..|..|||:.||.||::|.|.:.||.:|::|.|||||
 Frog  1123 QVHYEIRRNDEIISFFNDFSDHLAEEALWELSLKIKPR 1160

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	61/136 (45%)
		RasGEF	1335..1558	CDD:238087	151/222 (68%)
rapgef1	XP_031746374.1	PHA03247	<182..736	CDD:223021	158/739 (21%)
		RasGEFN	783..918	CDD:214571	64/144 (44%)
		RasGEF	932..1161	CDD:214539	157/230 (68%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	253	1.000	Domainoid score	I2035
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	537	1.000	Inparanoid score	I1172
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D124512at33208
OrthoFinder	1	1.000	-	-		FOG0006253
OrthoInspector	1	1.000	-	-		oto103383
Panther	1	1.100	-	-	LDO	PTHR23113
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3984
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	7.160