Protein Alignment C3G and SOS2

DIOPT Version :10

• Sequence 1: NP_572350.2
• Gene: C3G / 31618
• FlyBaseID: FBgn0259228
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: XP_047287669.1
• Gene: SOS2 / 6655
• HGNCID: 11188
• Length: 1397
• Species: Homo sapiens
• Alignment Length: 573
• Identity: 135/573 - (23%)
• Similarity: 236/573 - (41%)
• Gaps: 139/573 - (24%)

  Fly  1083 HSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAVH-ESVKPANVD------ED 1140
            |.|..        |..|..:|..|...:..||:....|   .|:::| .|.....:|      |:
Human   573 HKHAF--------ELVSKDENSIIFAAKSAEEKNNWMA---ALISLHYRSTLDRMLDSVLLKEEN 626

  Fly  1141 EEAERADMLINMLEEVNITRYLILKKRE----EDG-------PEVKGGYIDALIVHASRVQKVAD 1194
            |:..|       |....:.|:::....|    ||.       |.:|||.:..||...: ....||
Human   627 EQPLR-------LPSPEVYRFVVKDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLT-YHMYAD 683

  Fly  1195 NAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDLTSTDLTSQ 1259
            ..|...|:||:|:|.:|.:::..|..|:     ::.:.:...|.:   |.:.......|.||
Human   684 PNFVRTFLTTYRSFCKPQELLSLLIERF-----EIPEPEPTDADK---LAIEKGEQPISADL--- 737

  Fly  1260 LLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTL--------YKEPKVYGFVGEL-------GGA 1309
                                 |..|.::|:.|.|        :.|...|.|..:|       ...
Human   738 ---------------------KRFRKEYVQPVQLRILNVFRHWVEHHFYDFERDLELLERLESFI 781

  Fly  1310 GSVGGAGI----------------AGSGGCSGTAGGGNQP----------------SLLDLKSLE 1342
            .||.|..:                |.:.|.|......:.|                .|:.|..:|
Human   782 SSVRGKAMKKWVESIAKIIRRKKQAQANGVSHNITFESPPPPIEWHISKPGQFETFDLMTLHPIE 846

  Fly  1343 IAEQMTLLDAELFTKIEIPEVL--LFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKER 1405
            ||.|:|||:::|:.|::..|::  ::.|:..|..||||.|...|...::.|....|:..::.:||
Human   847 IARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFEER 911

  Fly  1406 EKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLEWQ-KGITEEVRSFCALID-----SSS 1464
            ...:::.|:|::..:.:||:|..|.::||::|..:.||:.. :.:.|..|.   ::|     |..
Human   912 VAVLSRIIEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKRK---ILDEAVELSQD 973

  Fly  1465 SFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYL---SKGVINFSKRWQQYNIIDNMKRFK 1526
            .|:.|...|...||||:|:.|:.|.::.....||.|:|   .|.:||||||.:...|...:::::
Human   974 HFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNNDFLKKKGKDLINFSKRRKVAEITGEIQQYQ 1038

  Fly  1527 KCAYPFRRNERIIRFFDNFKDFMG---EEE----MWQISEKIKPRG-RRPVNY 1571
            ...|..|....:.|||:|... ||   |:|    ::..|.:|:||. ::|..:
Human  1039 NQPYCLRIEPDMRRFFENLNP-MGSASEKEFTDYLFNKSLEIEPRNCKQPPRF 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	31/150 (21%)
		RasGEF	1335..1558	CDD:238087	71/240 (30%)
SOS2	XP_047287669.1	HFD_SOS1_rpt1	18..142	CDD:467039
		HFD_SOS1_rpt2	151..219	CDD:467040
		RhoGEF	264..451	CDD:238091
		PH_SOS	502..608	CDD:269963	10/45 (22%)
		RasGEFN	660..804	CDD:214571	34/176 (19%)
		RasGEF	839..1078	CDD:238087	72/242 (30%)