Protein Alignment C3G and SOS1

DIOPT Version :10

• Sequence 1: NP_572350.2
• Gene: C3G / 31618
• FlyBaseID: FBgn0259228
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_005624.2
• Gene: SOS1 / 6654
• HGNCID: 11187
• Length: 1333
• Species: Homo sapiens
• Alignment Length: 861
• Identity: 190/861 - (22%)
• Similarity: 331/861 - (38%)
• Gaps: 233/861 - (27%)

  Fly   821 DLAPAL---PPKSIQRSSLTRHDSPGVGDELDEVQSSSGWASHRSSQSE--------VAELRQLS 874
            |||..|   |.:|..|..|    .||..|......|..|.|.:..|..|        |.....|:
Human   285 DLAEELAFDPYESYARDIL----RPGFHDRFLSQLSKPGAALYLQSIGEGFKEAVQYVLPRLLLA 345

  Fly   875 PLHHLNHHPHTASAGQLQQWHSKHHSLIEGPRLQLAGSGSCSAFDQRHLDQEPPPLPIKKKHILA 939
            |::|..|                :..|::    ||         :::..|||..  ...|:.|.|
Human   346 PVYHCLH----------------YFELLK----QL---------EEKSEDQEDK--ECLKQAITA 379

  Fly   940 YM-------EICSASTRSIEQHRHTMHACNISRNISHSQTMNIMPMSKELSPELEMPPALPPKNY 997
            .:       :|||   :|:.:.|.:..||..     :||.|.    .|:|        |:...|.
Human   380 LLNVQSGMEKICS---KSLAKRRLSESACRF-----YSQQMK----GKQL--------AIKKMNE 424

  Fly   998 KQRK------------ATSMVASPTLQPVIVTTPPPSPKPTLGENGSTGRPDSRMATVCEELNDA 1050
            .|:.            ....:...||..|                   |....|...:.:.|  .
Human   425 IQKNIDGWEGKDIGQCCNEFIMEGTLTRV-------------------GAKHERHIFLFDGL--M 468

  Fly  1051 VASEDAMPEPRSPVLDSNE------------NVSAVDDGQTFYCHSHQLPAA-EMEMSEDASSAD 1102
            :..:....:||.|...:.|            .::..||... |.|:.::... |..:...|.||:
Human   469 ICCKSNHGQPRLPGASNAEYRLKEKFFMRKVQINDKDDTNE-YKHAFEIILKDENSVIFSAKSAE 532

  Fly  1103 NQ------------PITTPQVLEE---QEEPTAESR-PLVAVHESVKPANVDEDEEAERADMLIN 1151
            .:            ..|..::|:.   |||...:.| |...|:...:|   |.:|         |
Human   533 EKNNWMAALISLQYRSTLERMLDVTMLQEEKEEQMRLPSADVYRFAEP---DSEE---------N 585

  Fly  1152 MLEEVNITRYLILKKREEDG-PEVKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVI 1215
            ::.|.|:        :.:.| |.:|.|.:..||...: ....||..|...|:||:|:|.:|.:::
Human   586 IIFEENM--------QPKAGIPIIKAGTVIKLIERLT-YHMYADPNFVRTFLTTYRSFCKPQELL 641

  Fly  1216 EKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLA 1280
            ..:..|:     ::.:.:...|.       |:..:.....|:::|.....|::..:    ||.:.
Human   642 SLIIERF-----EIPEPEPTEAD-------RIAIENGDQPLSAELKRFRKEYIQPV----QLRVL 690

  Fly  1281 KLLRNKFVE------KVTLYKEPKVYGFVGELGGAGS----------VGGAGIAGSGGCSGTAGG 1329
            .:.|: :||      :...|...::..|:|.:.|...          :....||...|.......
Human   691 NVCRH-WVEHHFYDFERDAYLLQRMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITF 754

  Fly  1330 GNQP----------------SLLDLKSLEIAEQMTLLDAELFTKIEIPEVL--LFAKDQCEEKSP 1376
            .:.|                .||.|..:|||.|:|||:::|:..::..|::  ::.|:..|..||
Human   755 QSSPPTVEWHISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSP 819

  Fly  1377 NLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIR 1441
            ||.|...|...::.|....|:..::.:||...|::.|:|::..:::||:|..|.::||::|.|:.
Human   820 NLLKMIRHTTNLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVY 884

  Fly  1442 RLEW--------QKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGN 1498
            ||:.        ||.|.||....     |...::.|...|...||||:|:.|:.|.::.....||
Human   885 RLDHTFEQIPSRQKKILEEAHEL-----SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGN 944

  Fly  1499 QDYL---SKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMG---EEE---- 1553
            .:.|   .|.:||||||.:...|...:::::...|..|....|.|||:|... ||   |:|
Human   945 PEVLKRHGKELINFSKRRKVAEITGEIQQYQNQPYCLRVESDIKRFFENLNP-MGNSMEKEFTDY 1008

  Fly  1554 MWQISEKIKPRGRRPV 1569
            ::..|.:|:||..:|:
Human  1009 LFNKSLEIEPRNPKPL 1024

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	29/142 (20%)
		RasGEF	1335..1558	CDD:238087	74/242 (31%)
SOS1	NP_005624.2	HFD_SOS1_rpt1	18..95	CDD:467039
		HFD_SOS1_rpt2	104..177	CDD:467040
		RhoGEF	204..389	CDD:214619	30/138 (22%)
		PH_SOS	439..545	CDD:269963	18/127 (14%)
		RasGEFN	597..741	CDD:214571	30/161 (19%)
		RasGEF	776..1015	CDD:238087	75/244 (31%)
		PTZ00449	<1018..1319	CDD:185628	3/7 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1019..1103		2/6 (33%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1129..1333