DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C3G and Rapgef1

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_038962085.1	Gene:	Rapgef1 / 63881	RGDID:	619793	Length:	1269	Species:	Rattus norvegicus

Alignment Length:	1502	Identity:	452/1502 - (30%)
Similarity:	667/1502 - (44%)	Gaps:	447/1502 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 NSLKGTKLARRAR--SFKDDLIEKISLMRTTNNTLGRSHSPHSPRT--KHG-----TKAP--PTT 315
            |:::..|..|::.  .:|.| .::..|...|...:.:.|||...||  |.|     :|.|  |.:
  Rat     3 NAIEKQKPLRQSHLCPWKQD-SQRSHLSSFTMKLMDKFHSPKIKRTPSKKGKPAEVSKTPEKPVS 66

  Fly   316 EEV---------------------LRSTQT-------------LETHVKDISNALKHFRDV---- 342
            :|.                     ..||..             ||...|::.:||::|:.:
  Rat    67 KEARDRFLPEGYPIPLDLEQQAVEFMSTSAVDSRSQRQKNLCWLEEKEKEVVSALRYFKTIVDKM 131

  Fly   343 -ILKKKLEVLPGNGTVILETIASMYSVIQTYTLNENSAIMSSATLQVYQSLGKLIKLCDEVML-- 404
             |.||.||:|||:.:.:||.|..:   :||....::|:.:||...:|||||..||:..|:|||
  Rat   132 AIDKKVLEMLPGSASKVLEAILPL---VQTDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEG 193

  Fly   405 --SEDSGECASLSNENVREVIDLLEDAVRNLVTLA---QGKLKEQDQCAFRYSGSGLGGIGAAAE 464
              |||.....:     |:.||..:.|.|:.||.|.   ||:
  Rat   194 VNSEDKEMVTT-----VKGVIKAVLDGVKELVRLTIEKQGR------------------------ 229

  Fly   465 IMGAVTASPGASVPGTGVMRVSAAESAAQRTSLPDIALTPKERDILEQHNVNPMRGSHSTESILR 529
                    |..:.|.......|..:.::..:|.|::.||.:|.:||.:.:|:|     |||.:..
  Rat   230 --------PSPTSPVKPSSPASKPDGSSHFSSQPELPLTEREMEILNKTSVSP-----STELLPD 281

  Fly   530 DTS---PPPKPPLP------------NRASNPPPLPPKRRSQPSASAGTVGVGCSSSTSTSNQAS 579
            .||   .|||||||            :.:|:||.||||:| |.:.|...|.|....|.:.|..:.
  Rat   282 STSEEVAPPKPPLPGIRVVDNSLPGFSVSSSPPALPPKKR-QSAPSPTRVAVVAPMSRAVSGSSL 345

  Fly   580 PLPYAQSHNISLNS---DLDCSSNISLLNYGVDRLSVRSRSPDENSQCSFDSALNHSREEEDQQQ 641
            |        :.:|.   |::|        |...|||..|||      |..:|
  Rat   346 P--------VGINRQDFDVEC--------YTQRRLSGGSRS------CGGES------------- 375

  Fly   642 QHQHLRSFPKLAAMMDEDMDKMVSYSAAIDDKTQTPLSTGGGIAGVAGGTGGAGEGVAAAASGDG 706
                    |:|                       :|.|:.|.::       .:.|.:::.....|
  Rat   376 --------PRL-----------------------SPCSSTGKLS-------RSDEQLSSLDRDSG 402

  Fly   707 ETNSNRHSNESGFVSMREFRTSTQTTDYSVQSSTKSSSSNSEIAFSISESTAVGSSSEYQQISQL 771
            :.:.|               ||.:|.|:                          ...:|:.:.|.
  Rat   403 QCSRN---------------TSCETLDH--------------------------YDPDYEFLQQD 426

  Fly   772 VSHSQRHISSSSSSCTTTT------TSSSTTTGY------GSSEVEQLQQQQQQQTTTTPADLAP 824
            :|::.:  :...::|..:.      .|.....||      ||.    |||..||  |.||    |
  Rat   427 LSNADQ--TPPQAACNLSPLPESMGESGPPFVGYSFQLPLGSC----LQQDGQQ--TDTP----P 479

  Fly   825 ALPPKSIQRSSLTRHDSPGVGDELDEVQSSSG----WASHRSSQSEVAELRQLSPLHHLNHHPHT 885
            |||.|. :||:::            :...|||    :..|.|....::|....:|...:::.|..
  Rat   480 ALPEKK-RRSAVS------------QTTDSSGCRVSYERHPSQYDNISEDDLQNPAQPVSYPPFA 531

  Fly   886 ASAGQLQQWHSKHHSLIEGPRLQLAGSGSC--SAFDQRHLDQEPPPLPIKK-KHILAYMEICSAS 947
            |.. ..||..|       ...::..|..|.  ||.|    .::|||||.|| ||:||||::....
  Rat   532 AIL-PFQQGAS-------STPVEFVGDFSVPESAGD----PEKPPPLPEKKNKHMLAYMQLLEDY 584

  Fly   948 TRSIEQHRHTMHACNISRNISHSQTMNIMPM--------SKELSPELEMPPALPPKNYKQRK--- 1001
            :   |......:....|.:|...:...:|.:        ..:.:.||..||||||   |||:
  Rat   585 S---EPQPSMFYQTPQSEHIYQQKNKMLMEVYGFSDSFCGSDSTQELAPPPALPP---KQRQLQA 643

  Fly  1002 ---ATSMVASPTLQPVIVTTPPPSPKPTLGENGSTGR---------------------------- 1035
               |:|...|..:|...|...|        |:||..:
  Rat   644 SYAASSFSVSHCVQQTKVAFTP--------EDGSAAQGLSVSVSNSFLNRHGSLPVPSYKSVFRS 700

  Fly  1036 ------------------PDSRMATVCEELNDAVASEDAMPEPRSP------------------- 1063
                              |.|..:.....::.:.:|:.|:|...||
  Rat   701 YSQDFMPHHQASVQPFLPPTSSSSPHFPPVHASQSSDLAVPTVSSPPPSTVDGPLSSSQDSSFHG 765

  Fly  1064 ----------VLDSNENVSAVDDGQTFYCHSHQLPAAEMEMS----EDASSADNQP----ITTPQ 1110
                      ..||:||.|:.:.|...|.:.:.......|::    |..|..|..|    :::..
  Rat   766 NPVRLPSETSFTDSSENASSEEAGGGEYVNLYSSGQTSEELAPSGGEPPSGKDGHPRDLSVSSAS 830

  Fly  1111 VLEEQEEPTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDGPEVK 1175
            ..:.:|......:.|.|:..:.....|||          :::::...|...|.||:..:|||:|:
  Rat   831 GKDSRENGERSPKSLDALESAQSEEEVDE----------LSLIDHNEIMARLTLKQEGDDGPDVR 885

  Fly  1176 GGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKET 1240
            ||..|.|:|||:...:.....:||||:||:||||.|.::|:||..||..|.......|::.:|.|
  Rat   886 GGSGDILLVHATETDRKDLVLYCEAFLTTYRTFISPEELIKKLQCRYEKFSPFADTFKKRVSKNT 950

  Fly  1241 FALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYK--------EP 1297
            |.:|||||::|...:||.::|.||:|.|::|||||:|.||::||...::||...|        :|
  Rat   951 FFVLVRVVDELCLVELTEEILKLLMELVFRLVCSGELSLARVLRKNILDKVDQKKLLRCAHSDQP 1015

  Fly  1298 KVYGFVGELGGAGSVGGAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPE 1362
                          :...|:|...|           :|.|..|.|||||:||||||||.||||||
  Rat  1016 --------------LAARGVAARPG-----------TLHDFHSHEIAEQLTLLDAELFYKIEIPE 1055

  Fly  1363 VLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNS 1427
            |||:||:|.|||||||.:||||||.||||.||.|:..:.|::||:.:.|||||||||||:||:||
  Rat  1056 VLLWAKEQNEEKSPNLTQFTEHFNNMSYWVRSVIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNS 1120

  Fly  1428 YLALLSALDSGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLT 1492
            |||:||||||.||||||||:..:|.:..:|.||||||||||||.||:|..||||||:||||||||
  Rat  1121 YLAILSALDSAPIRRLEWQRQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLT 1185

  Fly  1493 FVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMGEEEMWQI 1557
            |||:||.||:. |.:||||||||:||:|:|:.|::..|..|||:.||.||::|.|.:.||.:|::
  Rat  1186 FVHLGNPDYID-GKVNFSKRWQQFNILDSMRCFQQVHYEIRRNDDIINFFNDFSDHLAEEALWEL 1249

  Fly  1558 SEKIKPR 1564
            |.|||||
  Rat  1250 SLKIKPR 1256

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	59/143 (41%)
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	148/222 (67%)
Rapgef1	XP_038962085.1	PHA03247	<230..351	CDD:223021	39/134 (29%)
		RasGEFN	880..1021	CDD:214571	59/154 (38%)
		RasGEF	1028..1257	CDD:214539	154/230 (67%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166344536
Domainoid	1	1.000	253	1.000	Domainoid score	I2016
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	530	1.000	Inparanoid score	I1177
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D124512at33208
OrthoFinder	1	1.000	-	-		FOG0006253
OrthoInspector	1	1.000	-	-		oto96682
orthoMCL	1	0.900	-	-		OOG6_106476
Panther	1	1.100	-	-	LDO	PTHR23113
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3984
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.760