| Sequence 1: | NP_572350.2 | Gene: | C3G / 31618 | FlyBaseID: | FBgn0259228 | Length: | 1571 | Species: | Drosophila melanogaster |
|---|---|---|---|---|---|---|---|---|---|
| Sequence 2: | NP_008840.1 | Gene: | RASGRF2 / 5924 | HGNCID: | 9876 | Length: | 1237 | Species: | Homo sapiens |
| Alignment Length: | 695 | Identity: | 146/695 - (21%) |
|---|---|---|---|
| Similarity: | 255/695 - (36%) | Gaps: | 192/695 - (27%) |
- Green bases have known domain annotations that are detailed below.
|
Fly 895 HSKHHSLIEG--PRLQLAGSGSCSAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHRHT 957
Fly 958 MHACNISRNISHSQTMN----IMPMSKELSP--ELEMPPALPPKNYKQRKATSMVASPTLQPVIV 1016
Fly 1017 TTPPPSPKPTLGENGSTGRPDSRMATVCEELNDAV--ASEDAMPEPRSPVLDSNENVSAVDDGQT 1079
Fly 1080 FYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAVHESVKPANVDEDEEAE 1144
Fly 1145 RADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFI 1209
Fly 1210 QPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCS 1274
Fly 1275 GQ----LYLAKLLRNKFVEKVTLYKEPKVYGFVGELGGAGSVGGAGIAGSGGCSGTAGGGNQPSL 1335
Fly 1336 LDLKSLEIAEQMTLLDAELFTKIEIPEVL--LFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILR 1398
Fly 1399 LQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE--WQKGITEEVRSFCALID 1461
Fly 1462 -------SSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNII 1519
Fly 1520 DNMKRFKKCAYPFRRNERIIRFFDNFKDFMGEEEMWQISEKIKPR 1564 |
| Gene | Sequence | Domain | Region | External ID | Identity |
|---|---|---|---|---|---|
| C3G | NP_572350.2 | RasGEFN | 1170..1306 | CDD:214571 | 20/139 (14%) |
| RasGEF | 1335..1558 | CDD:238087 | 68/233 (29%) | ||
| RASGRF2 | NP_008840.1 | PH_RasGRF1_2 | 19..158 | CDD:270081 | |
| RhoGEF | 247..428 | CDD:214619 | |||
| PH | 480..588 | CDD:214574 | |||
| RasGEF_N | 638..>686 | CDD:306971 | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 710..809 | 30/143 (21%) | |||
| Regulates proteasomal degradation. /evidence=ECO:0000250 | 744..752 | 1/7 (14%) | |||
| Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite | 829..873 | 12/71 (17%) | |||
| RasGEFN | <901..972 | CDD:214571 | 13/81 (16%) | ||
| RasGEF | 998..1234 | CDD:214539 | 71/280 (25%) | ||
| Responsible of the affinity for farnesylated versus geranylgeranylated Ras. /evidence=ECO:0000250 | 1099..1128 | 10/32 (31%) | |||
| Blue background indicates that the domain is not in the aligned region. | |||||
| Tool | Simple Score | Weighted Score | Original Tool Information | |||
|---|---|---|---|---|---|---|
| BLAST Result | Score | Score Type | Cluster ID | |||
| Compara | 0 | 0.000 | Not matched by this tool. | |||
| Domainoid | 0 | 0.000 | Not matched by this tool. | |||
| eggNOG | 1 | 0.900 | - | - | E1_KOG3417 | |
| Hieranoid | 0 | 0.000 | Not matched by this tool. | |||
| Homologene | 0 | 0.000 | Not matched by this tool. | |||
| Inparanoid | 0 | 0.000 | Not matched by this tool. | |||
| Isobase | 0 | 0.000 | Not matched by this tool. | |||
| OMA | 0 | 0.000 | Not matched by this tool. | |||
| OrthoDB | 0 | 0.000 | Not matched by this tool. | |||
| OrthoFinder | 0 | 0.000 | Not matched by this tool. | |||
| OrthoInspector | 0 | 0.000 | Not matched by this tool. | |||
| orthoMCL | 0 | 0.000 | Not matched by this tool. | |||
| Panther | 0 | 0.000 | Not matched by this tool. | |||
| Phylome | 1 | 0.910 | - | - | ||
| RoundUp | 1 | 1.030 | - | avgDist | Average_Evolutionary_Distance | R2063 |
| SonicParanoid | 0 | 0.000 | Not matched by this tool. | |||
| SwiftOrtho | 0 | 0.000 | Not matched by this tool. | |||
| TreeFam | 0 | 0.000 | Not matched by this tool. | |||
| User_Submission | 0 | 0.000 | Not matched by this tool. | |||
| 3 | 2.840 | |||||