DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C3G and RALGPS2

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_689876.2	Gene:	RALGPS2 / 55103	HGNCID:	30279	Length:	583	Species:	Homo sapiens

Alignment Length:	294	Identity:	82/294 - (27%)
Similarity:	140/294 - (47%)	Gaps:	40/294 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly  1307 GGAGSVGGAGIAG--SGGCSGTAGGGNQP---------SLLDLKSLEIAEQMTLLDAELFTKIEI 1360
            |.|.||..|..|.  |......:..|::.         .:|.:...|.|.|:||:|..:|..|:.
Human     6 GQASSVNIAATASEKSSSSESLSDKGSELKKSFDAVVFDVLKVTPEEYAGQITLMDVPVFKAIQP 70

  Fly  1361 PEVLLFAKDQCEEKS--PNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMN 1423
            .|:.....::.|:.|  ||...||..||.:|:|...:||..|..|.|.:.::.:||..|.|.::|
Human    71 DELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKIRAEVLSHYIKTAKKLYELN 135

  Fly  1424 NYNSYLALLSALDSGPIRRL--EW------QKGITEEVRSFCALIDSSSSFRAYRQALAETNPPC 1480
            |.::.:|::|.|.|.||.||  .|      .|...|::....:..|:....|.|..:|..|  ||
Human   136 NLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKEDNYKRLRDYISSLKMT--PC 198

  Fly  1481 IPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRF-----KKCAYPF------RR 1534
            |||:|:.|.|||::   :..|.|.|.|  .:..|:.|:::|:.|.     :.|.|..      ::
Human   199 IPYLGIYLSDLTYI---DSAYPSTGSI--LENEQRSNLMNNILRIISDLQQSCEYDIPMLPHVQK 258

  Fly  1535 NERIIRFFDNFKDFMGEEEMWQISEKIKPRGRRP 1568
            ....:::.:..:.|: |::.:::|.||:|....|
Human   259 YLNSVQYIEELQKFV-EDDNYKLSLKIEPGTSTP 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	69/243 (28%)
RALGPS2	NP_689876.2	RasGEF	45..286	CDD:214539	72/248 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	283..314		4/9 (44%)
		PXXP	324..327
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	372..406
		Required for stimulation of nucleotide exchange by RALA. /evidence=ECO:0000250	459..583
		PH_RalGPS1_2	459..574	CDD:270120
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810