DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C3G and Rgl

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001261814.1	Gene:	Rgl / 44115	FlyBaseID:	FBgn0026376	Length:	973	Species:	Drosophila melanogaster

Alignment Length:	774	Identity:	165/774 - (21%)
Similarity:	284/774 - (36%)	Gaps:	201/774 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   920 QRHLDQEPPPLPIKKKHILAY-MEICSASTRSIEQHRHTMHACNISRNISHSQTMNIMPMSKELS 983
            |:|  |:.|.|  .|.|..|| ::..:...|::..........|..|.::::.|.......::..
  Fly    15 QKH--QQKPAL--IKSHTCAYQLQDLTGYNRALMPPLDNTDFSNAWRQVNNNTTSQSCAYHQQRQ 75

  Fly   984 PELEMPPALPPKNY-------KQRKATSMVASPTLQPVIVTTPPPSPKPTLGENGSTGRPDSRMA 1041
            .:.:...|...|.:       :||| .||.             |..|.....::....:..||.|
  Fly    76 QQQQQQDAKDSKRHYHHHTCPRQRK-KSMT-------------PVEPTHLCQKHQEAKQRRSRSA 126

  Fly  1042 TVCEELNDAVASEDAMPEPRSPVLDSNENVSAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPI 1106
            :.....|.:..|.|.: :..|.||::...|.|   ...:.|.........:........|.|...
  Fly   127 SAKPRRNSSYHSYDDL-DVSSAVLNAERKVVA---SLKYLCACTGATLRNLSKKTKDLHAKNYTY 187

  Fly  1107 TTP--QVLEEQEEPTA---ESRPLVAVHESVKPANVDEDEEAERADMLINMLE-EVNITRYLILK 1165
            |.|  ::..|:.|..|   .....|..|.....|:.|.|:|       |:.|| |....|:
  Fly   188 TKPTWRLWGEEHEKNAIFTVYLKKVRYHRPTPTASNDSDDE-------ISHLEWETVRVRF---- 241

  Fly  1166 KREEDGPEVKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYF----- 1225
                    ||...:..|:...:......::.|...|::|:|||..|..|:..||.||...
  Fly   242 --------VKAATLARLVEALATDDGELESTFINVFLSTYRTFSTPKQVLSLLTQRYDALHEKHL 298

  Fly  1226 --FCQVQDNKQ-------------KAAKETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSG 1275
              ..|.|.|.|             :..|:|....:.|..|....|.....|..::.|..:.:...
  Fly   299 EELEQAQQNGQVMDPAYDPHASIHEQHKKTLVSALHVWLDGFPEDWHEDNLQQILAFATKRLKRS 363

  Fly  1276 QLYLAKLLRNKFVEKVTLYKEPKVYGFVGELGGAGSVGGAGIAGSGGCSGTAGGGNQP------- 1333
            .|::..|.|.:.:.|.:||               |:.||:|.:.:.|.|..:...:|.
  Fly   364 DLHIKVLNRLERLIKQSLY---------------GNGGGSGGSENNGHSWLSAARSQQMQQFMIP 413

  Fly  1334 ----SLLDLKS---------------------------------LEIAEQMTLLDAELFTKIEIP 1361
                |..||..                                 ...|||:|.:|.|||.:: ||
  Fly   414 THYGSSYDLTDQFNGMYLSPMGHGPIYRGPTHFLQAFRFPHVPVRHFAEQLTRMDTELFKRL-IP 477

  Fly  1362 EVLLFAKDQC-------------EEKSPNLNKFTEHFNKMSYWARSKIL--RLQDAKEREKHVNK 1411
            .       ||             |.....:|:    ||.:.:...|.||  ||: .:||..::::
  Fly   478 H-------QCLGHTWARRDSGGSETVVATINQ----FNAVLFRVVSSILIDRLK-PQERALNISR 530

  Fly  1412 FIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE--WQ------KGITEEVRSFCALIDSSSSFRA 1468
            :|.|.:.||.:.|::|..|::|||:|..|.||.  |:      ..:..|:.:.|:..:::.:.|.
  Fly   531 WIDIAQELRMLKNFSSLKAIISALNSNSIYRLSKIWEVLPKERMEVFTELANICSEDNNAWTLRE 595

  Fly  1469 Y--RQALAETNPP-----------------------CIPYIGLILQDLTFVHVGNQDYLSKG-VI 1507
            .  |:..|:...|                       .|||:|..|.|||.:|..|.|||::. :|
  Fly   596 VLKREGTAKNPDPGSDHSDRHLQKLILNLGTQTSHGTIPYLGTFLTDLTMIHTANPDYLTENKLI 660

  Fly  1508 NFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFM---GEEEMWQISEKIKP 1563
            ||.|:.:::.::..:|..:..|..:  |.:....||::.:.|   .|.|.:::|.:::|
  Fly   661 NFDKKRKEFEVLAQIKLLQGAANTY--NLQADALFDHWFNSMPVFDEREAFELSCRLEP 717

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	32/155 (21%)
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	71/307 (23%)
Rgl	NP_001261814.1	REM	246..378	CDD:100121	27/131 (21%)
		RasGEF	454..719	CDD:214539	71/279 (25%)
		RalGDS_RA	858..946	CDD:176351
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467921
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940