Protein Alignment C3G and Sos

DIOPT Version :10

• Sequence 1: NP_572350.2
• Gene: C3G / 31618
• FlyBaseID: FBgn0259228
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_476597.2
• Gene: Sos / 34790
• FlyBaseID: FBgn0001965
• Length: 1596
• Species: Drosophila melanogaster
• Alignment Length: 1309
• Identity: 246/1309 - (18%)
• Similarity: 434/1309 - (33%)
• Gaps: 454/1309 - (34%)

  Fly   453 GSGLGGIGAAAEIMGAVTASPGASVPGTGVMRV--------SAAESAAQRTSLPDIALTPKERDI 509
            |.|.||.|:.::..|.     |..:.|.||..:        :..|:||:...|    .||..:.:
  Fly    25 GGGSGGSGSGSQGGGG-----GIGIGGGGVAGLQDCDGYDFTKCENAARWRGL----FTPSLKKV 80

  Fly   510 LEQHNVNPMRGSHSTESI-------LRDTSPPPKPPLPN---------RASNPPPL--------- 549
            |||  |:| |.:...:::       ||..:.....|||:         ..|.|.|:
  Fly    81 LEQ--VHP-RVTAKEDALLYVEKLCLRLLAMLCAKPLPHSVQDVEEKVNKSFPAPIDQWALNEAK 142

  Fly   550 ----PPKRRS--------------------QPSASAGTVGVGCSSSTSTSNQASPLPYAQSHNIS 590
                ..||:|                    ..|.||..|.|....|......|.......:|...
  Fly   143 EVINSKKRKSVLPTEKVHTLLQKDVLQYKIDSSVSAFLVAVLEYISADILKMAGDYVIKIAHCEI 207

  Fly   591 LNSDLDCSSN-----ISLLNYGVDRLSVRSRS-PDENSQCSFDSALNHSREEEDQQQQHQHLRSF 649
            ...|::...|     :.:||.....:.....| |.:.:..:::..:.....:|.|.|:..|:
  Fly   208 TKEDIEVVMNADRVLMDMLNQSEAHILPSPLSLPAQRASATYEETVKELIHDEKQYQRDLHM--- 269

  Fly   650 PKLAAMMDEDMDKMVSYSAAIDDKTQTPLSTGGGIAGVAGGTGGAGEGVAAAASGDGETNSNRHS 714
              :..:..|::.|:||     |.:...|:
  Fly   270 --IIRVFREELVKIVS-----DPRELEPI------------------------------------ 291

  Fly   715 NESGFVSMREFRTSTQTTDYSVQSSTKSSSSNSEIAFSISESTAVGSSSE----------YQQIS 769
                |.::.:....|.|...|::...:.|...|        :..|||..|          |::.:
  Fly   292 ----FSNIMDIYEVTVTLLGSLEDVIEMSQEQS--------APCVGSCFEELAEAEEFDVYKKYA 344

  Fly   770 QLVSHSQRHISSSSSSCTTTTTSSSTTTGYG---------------------------------S 801
            ..|: ||....:.::..:....||.||.|:|                                 |
  Fly   345 YDVT-SQASRDALNNLLSKPGASSLTTAGHGFRDAVKYYLPKLLLVPICHAFVYFDYIKHLKDLS 408

  Fly   802 SEVEQLQQQQQQQTTTTP--ADLAPALPPKSIQRSSLTRHDSPGVGDELDEVQSSSGWASHRSSQ 864
            |..:.::..:|.|....|  .||...:       :||::.....|          ||....:.:.
  Fly   409 SSQDDIESFEQVQGLLHPLHCDLEKVM-------ASLSKERQVPV----------SGRVRRQLAI 456

  Fly   865 SEVAELRQLSPLHHLNHHPHTASAGQLQQWHSKH-----HSLIEGPRLQLAGSGSCSAFDQRHLD 924
            ....||:.                 :::.|..|.     :..|....|...|||       :.:.
  Fly   457 ERTRELQM-----------------KVEHWEDKDVGQNCNEFIREDSLSKLGSG-------KRIW 497

  Fly   925 QEPPPLPIKKKHIL--AYMEICSASTRSIEQHRHTMHACNISRNISHSQTMNIMPMSKELSPELE 987
            .|       :|..|  ..|.:|.|:|:                    .||    |.:...:.:..
  Fly   498 SE-------RKVFLFDGLMVLCKANTK--------------------KQT----PSAGATAYDYR 531

  Fly   988 MPPALPPKNYKQRKATSMVASPTLQPVIVTTPPPSPKPTLGENGSTGRPDSRMATVCEELNDAVA 1052
            :     .:.|..|:.                            ....||||         :|...
  Fly   532 L-----KEKYFMRRV----------------------------DINDRPDS---------DDLKN 554

  Fly  1053 SEDAMPEPRSPVLDSNENVSAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEE 1117
            |.:..|..:.|::.:.:|..          |.|.. .|::.|....|..|..   ...:|::.|.
  Fly   555 SFELAPRMQPPIVLTAKNAQ----------HKHDW-MADLLMVITKSMLDRH---LDSILQDIER 605

  Fly  1118 PTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDG-PEVKGG---- 1177
            ......|...:::...|.:.|.                      ::|::||..| |.:||.
  Fly   606 KHPLRMPSPEIYKFAVPDSGDN----------------------IVLEERESAGVPMIKGATLCK 648

  Fly  1178 YIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYT------------------- 1223
            .|:.|..|.     .||..|...|:||:|.|..|..:::.|..|:.
  Fly   649 LIERLTYHI-----YADPTFVRTFLTTYRYFCSPQQLLQLLVERFNIPDPSLVYQDTGTAGAGGM 708

  Fly  1224 --------YFFCQVQDNKQKAAKETFALLVRVVNDLT--------STDLTSQLLSLLVEFVYQLV 1272
                    :.....:|.|:...:....:..||:|.|.        ..:....||..|:.|:..:
  Fly   709 GGVGGDKEHKNSHREDWKRYRKEYVQPVQFRVLNVLRHWVDHHFYDFEKDPMLLEKLLNFLEHV- 772

  Fly  1273 CSGQLYLAKLLRNKFVEKVTLYKEPK----------VYGFVGELGGAGSVGGAGIAGSGGCSGTA 1327
             :|     |.:| |:|:.|....:.|          ||.:
  Fly   773 -NG-----KSMR-KWVDSVLKIVQRKNEQEKSNKKIVYAY------------------------- 805

  Fly  1328 GGGNQP--------------SLLDLKSLEIAEQMTLLDAELFTKIEIPEVL--LFAKDQCEEKSP 1376
              |:.|              :||.|..||:|.|:|||:.|::..::..|::  .:.|...|.|||
  Fly   806 --GHDPPPIEHHLSVPNDEITLLTLHPLELARQLTLLEFEMYKNVKPSELVGSPWTKKDKEVKSP 868

  Fly  1377 NLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIR 1441
            ||.|..:|...::.|....|...::.:||...:.:.|::|..:.::||:|..|::::|:.:..:.
  Fly   869 NLLKIMKHTTNVTRWIEKSITEAENYEERLAIMQRAIEVMMVMLELNNFNGILSIVAAMGTASVY 933

  Fly  1442 RLEWQ-KGITEEVRSF---CALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYL 1502
            ||.|. :|:.|..|.|   |..: |....:.|::.|...||||:|:.|..|.::..:..||.|.|
  Fly   934 RLRWTFQGLPERYRKFLEECREL-SDDHLKKYQERLRSINPPCVPFFGRYLTNILHLEEGNPDLL 997

  Fly  1503 SK-GVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMG------EEEMWQISEK 1560
            :. .:||||||.:...||..:::::...|.......|.:||:....|.|      .:.::..|.:
  Fly   998 ANTELINFSKRRKVAEIIGEIQQYQNQPYCLNEESTIRQFFEQLDPFNGLSDKQMSDYLYNESLR 1062

  Fly  1561 IKPRGRRPV 1569
            |:|||.:.|
  Fly  1063 IEPRGCKTV 1071

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	37/185 (20%)
		RasGEF	1335..1558	CDD:238087	68/235 (29%)
Sos	NP_476597.2	HFD_SOS1_rpt1	68..145	CDD:467039	17/83 (20%)
		HFD_SOS1_rpt2	153..227	CDD:467040	10/73 (14%)
		RhoGEF	249..432	CDD:238091	36/241 (15%)
		PH_SOS	476..586	CDD:269963	29/200 (15%)
		RasGEFN	637..791	CDD:214571	34/166 (20%)
		RasGEF	825..1062	CDD:238087	69/237 (29%)
		PHA03247	<1197..1502	CDD:223021