DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C3G and Rasgrp3

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_006239819.1	Gene:	Rasgrp3 / 313874	RGDID:	1304612	Length:	691	Species:	Rattus norvegicus

Alignment Length:	236	Identity:	57/236 - (24%)
Similarity:	117/236 - (49%)	Gaps:	6/236 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1338 LKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDA 1402
            |:.:|:||.:|.|:.:.|.:|...:...:....|.|.:|.|.:....||.:|.|.:..:|....|
  Rat   151 LEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSA 215

  Fly  1403 KEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE-----WQKGITEEVRSFCALIDS 1462
            ::|.:.:.|||.:.:.|.::.|:|:.:|::..|....|.||:     ....:|:.......|:.|
  Rat   216 QQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSS 280

  Fly  1463 SSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKK 1527
            :.::..||:|.|:.:...||.:|:.|:||..|||...|::.:..:|..|..|....:..:...:.
  Rat   281 NGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQN 345

  Fly  1528 CAYPFRRNERIIRFFDNFKD-FMGEEEMWQISEKIKPRGRR 1567
            .::....|..:|.......| :..|::::::|..::||..:
  Rat   346 ASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSK 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	54/225 (24%)
Rasgrp3	XP_006239819.1	REM	11..126	CDD:100121
		RasGEF	148..384	CDD:214539	56/232 (24%)
		EF-hand_7	428..478	CDD:404394
		C1_RASGRP3	488..546	CDD:410412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810