DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C3G and Sos1

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001094186.1	Gene:	Sos1 / 313845	RGDID:	1310949	Length:	1319	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	129/515 - (25%)
Similarity:	228/515 - (44%)	Gaps:	109/515 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly  1113 EEQEE----PTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDG-P 1172
            ||:||    |:|:      |:...:|   |.:|         |:|.|.|:        :.:.| |
  Rat   561 EEKEEHMRLPSAD------VYRFAEP---DSEE---------NILFEENV--------QPKAGIP 599

  Fly  1173 EVKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAA 1237
            .:|.|.:..||...: ....||..|...|:||:|:|.:|.:::..|..|:     ::.:.:...|
  Rat   600 IIKAGTVVKLIERLT-YHMYADPNFVRTFLTTYRSFCKPQELLNLLIERF-----EIPEPEPTEA 658

  Fly  1238 KETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRN-------KFVEKVTLYK 1295
            .       |:..:.....|:::|.....|::..:    ||.:..:.|:       .|...|.|.:
  Rat   659 D-------RIAIENGDQPLSAELKRFRKEYIQPV----QLRVLNVCRHWVEHHFYDFERDVDLLQ 712

  Fly  1296 EPKVYGFVGELGGAGS----------VGGAGIAGSGGCSGTAGGGNQP----------------S 1334
              ::..|:|.:.|...          :....||...|........|.|                .
  Rat   713 --RMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQNSPPTVEWHISRPGHIETFD 775

  Fly  1335 LLDLKSLEIAEQMTLLDAELFTKIEIPEVL--LFAKDQCEEKSPNLNKFTEHFNKMSYWARSKIL 1397
            ||.|..:|||.|:|||:::|:..::..|::  ::.|:..|..||||.|...|...::.|....|:
  Rat   776 LLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIV 840

  Fly  1398 RLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLEW--------QKGITEEVR 1454
            ..::.:||...|::.|:|::..:::||:|..|.::||::|.|:.||:.        ||.|.||..
  Rat   841 ETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIPSRQKKILEEAH 905

  Fly  1455 SFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYL---SKGVINFSKRWQQY 1516
            ..     |...::.|...|...||||:|:.|:.|.::.....||.:.|   .|.:||||||.:..
  Rat   906 EL-----SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLRRHGKELINFSKRRRVA 965

  Fly  1517 NIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMG---EEE----MWQISEKIKPRGRRPV 1569
            .|...:::::...|..|....|.|||:|... ||   |:|    ::..|.:|:||..:|:
  Rat   966 EITGEIQQYQNQPYCLRVESDIKRFFENLNP-MGNSMEKEFTDYLFNKSLEIEPRNPKPL 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	30/143 (21%)
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	74/242 (31%)
Sos1	NP_001094186.1	H2A	97..177	CDD:305064
		RhoGEF	204..389	CDD:214619
		PH_SOS	439..545	CDD:269963
		PH	445..546	CDD:278594
		RasGEFN	597..741	CDD:214571	31/162 (19%)
		RasGEF	776..1015	CDD:238087	75/244 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810