DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C3G and Ralgps2

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_038946679.1	Gene:	Ralgps2 / 304887	RGDID:	1311537	Length:	583	Species:	Rattus norvegicus

Alignment Length:	248	Identity:	73/248 - (29%)
Similarity:	126/248 - (50%)	Gaps:	29/248 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly  1342 EIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKS--PNLNKFTEHFNKMSYWARSKILRLQDAKE 1404
            |.|.|:||:|..:|..|:..|:.....::.|:.|  ||...||..||.:|:|...:||..|..|.
  Rat    52 EYAGQITLMDVPVFKAIQPDELSSCGWNKKEKYSSAPNAVAFTRRFNHVSFWVVREILHAQTLKI 116

  Fly  1405 REKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRL--EW------QKGITEEVRSFCALID 1461
            |.:.::.:||..|.|.::||.::.:|::|.|.|.||.||  .|      .|...|::....:..|
  Rat   117 RAEVLSHYIKTAKKLYELNNLHALMAVVSGLQSAPIFRLTKTWALLSRKDKTTFEKLEYVMSKED 181

  Fly  1462 SSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRF- 1525
            :....|.|..:|..|  |||||:|:.|.|||::   :..|.|.|.|  .:..|:.|:::|:.|.
  Rat   182 NYKRLRDYISSLKMT--PCIPYLGIYLSDLTYI---DSAYPSTGSI--LENEQRSNLMNNILRII 239

  Fly  1526 ----KKCAYPF------RRNERIIRFFDNFKDFMGEEEMWQISEKIKPRGRRP 1568
                :.|.|..      ::....:::.:..:.|: |::.:::|.||:|....|
  Rat   240 SDLQQSCEYDIPMLPHVQKYLNSVQYIEELQKFV-EDDNYKLSLKIEPGASTP 291

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	68/236 (29%)
Ralgps2	XP_038946679.1	RasGEF	45..286	CDD:214539	71/241 (29%)
Ralgps2	XP_038946679.1	PH_RalGPS1_2	459..574	CDD:270120
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810