Protein Alignment C3G and RAPGEF1

DIOPT Version :10

• Sequence 1: NP_572350.2
• Gene: C3G / 31618
• FlyBaseID: FBgn0259228
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: XP_011516873.1
• Gene: RAPGEF1 / 2889
• HGNCID: 4568
• Length: 1273
• Species: Homo sapiens
• Alignment Length: 1356
• Identity: 427/1356 - (31%)
• Similarity: 624/1356 - (46%)
• Gaps: 298/1356 - (21%)

  Fly   309 TKAPPTTEEVLRSTQTLETHVKDISNALKHFRDV-----ILKKKLEVLPGNGTVILETIASMYSV 368
            |.|..:..:..::...||...|::.:||::|:.:     |.||.||:|||:.:.:||.|..:
Human   103 TSAVASRSQRQKNLSWLEEKEKEVVSALRYFKTIVDKMAIDKKVLEMLPGSASKVLEAILPL--- 164

  Fly   369 IQTYTLNENSAIMSSATLQVYQSLGKLIKLCDEVML----SEDSGECASLSNENVREVIDLLEDA 429
            :|.....::|:.:||...:|||||..||:..|:|||    |||.....:     |:.||..:.|.
Human   165 VQNDPRIQHSSALSSCYSRVYQSLANLIRWSDQVMLEGVNSEDKEMVTT-----VKGVIKAVLDG 224

  Fly   430 VRNLVTLA---QGKLKEQDQCAFRYSGSGLGGIGAAAEIMGAVTASPGASVPGTGVMRVSAAESA 491
            |:.||.|.   ||:                                |..:.|      |..:..|
Human   225 VKELVRLTIEKQGR--------------------------------PSPTSP------VKPSSPA 251

  Fly   492 AQRTSLPDIALTPKERDILEQHNVNPMRGSHSTESILRDTS----PPPKPPLPN----RASNPPP 548
            ::.....::.||.:|.:||     |...|...:..:|.|.:    .|||||||.    ..|.||.
Human   252 SKPDGPAELPLTDREVEIL-----NKTTGMSQSTELLPDATDEEVAPPKPPLPGIRVVDNSPPPA 311

  Fly   549 LPPKRRSQPSASAGTVGVGCSSSTSTSNQASPLP----------YAQ------SHNISLNSD-LD 596
            ||||:| |.:.|...|.|....|.:||..:.|:.          |||      ||:....|. |.
Human   312 LPPKKR-QSAPSPTRVAVVAPMSRATSGSSLPVGINRQDFDVDCYAQRRLSGGSHSYGGESPRLS 375

  Fly   597 CSSNISLLNYGVDRLSVRSRSPDENSQCSFDSA---LNH-SREEEDQQQQHQHLRSFPKLAAM-- 655
            ..|:|..|:...::||...|   ::.|||.:::   |:| ..:.|..||...:....|:..|.
Human   376 PCSSIGKLSKSDEQLSSLDR---DSGQCSRNTSCETLDHYDPDYEFLQQDLSNADQIPQQTAWNL 437

  Fly   656 --MDEDMDKMVSYSAAIDDKTQTPL----STGGGIA-GVAGGTGGA----GEGVAAAASGDG--- 706
              :.|.:.:  |.|..:....|.||    ...|.:| |....|..|    ....||:.:.||
Human   438 SPLPESLGE--SGSPFLGPPFQLPLGGHPQPDGPLAPGQQTDTPPALPEKKRRSAASQTADGSGC 500

  Fly   707 ETNSNRHSNESGFVSMREFRT-----STQTTDYSVQSSTKSSSSNSEIAFSISESTAVGSSSEYQ 766
            ..:..||.::...:|..:.::     |.....::.....:...|::.:.| :.:.||..|:.:.:
Human   501 RVSYERHPSQYDNISGEDLQSTAPIPSVPYAPFAAILPFQHGGSSAPVEF-VGDFTAPESTGDPE 564

  Fly   767 QISQLVSHSQRHISSSSSSCTTTTTSSSTTTGYGSSEVEQLQQQQQQ------------------ 813
            :...|.....:|: .:........:....:..|.:.:.|.:.||:.:
Human   565 KPPPLPEKKNKHM-LAYMQLLEDYSEPQPSMFYQTPQNEHIYQQKNKLLMEVYGFSDSFSGVDSV 628

  Fly   814 QTTTTPADLAPALPPKSIQRSSLTRHDSPGVGDELDEVQSSSGWASHRSSQSEVAELRQLSPLHH 878
            |....|    ||||||..|..:..             ..||....||...|::||
Human   629 QELAPP----PALPPKQRQLQASC-------------AASSFSSVSHCVQQTKVA---------- 666

  Fly   879 LNHHPHTASAGQ------LQQWHSKHHSLIEGPRLQLAGSGSCSAFDQRHLDQEPPPLPIKKKHI 937
              ..|...||.|      ...:.|:|.||                           |:|..|...
Human   667 --FTPEDGSAAQGLSVSVSNSFLSRHGSL---------------------------PVPSYKSVF 702

  Fly   938 LAYMEICSASTRSIEQHRHTMHACNISRNISHSQTMNIMPMSKELSPELEMPPALPPKNYKQRKA 1002
            .:|.:                      ..:.|.|. ::.|.   |.|.....|..||.:..|
Human   703 RSYSQ----------------------DFVPHHQA-SVPPF---LPPTSSSSPHFPPAHQSQ--- 738

  Fly  1003 TSMVASPTLQPVIVTTPPPS----PKPTLGENGSTGRPDSRMATVC--EELNDAVASEDAMPEPR 1061
            :|.:|.||:     ..||||    |.....|:...|.      |||  .|.:...:||:|..|
Human   739 SSDLAVPTM-----AGPPPSTVDGPLSASQESSFHGN------TVCLPSETSFTDSSENASEE-- 790

  Fly  1062 SPVLDSNENVSAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLV 1126
               ....|.|:....||:    |.:|..:..|...........|.....|..:.....:|..|
Human   791 ---AGEGEYVNLYSSGQS----SEELAPSRGEPPAGKDGHPRDPSAVSGVPGKDSRDGSERAP-- 846

  Fly  1127 AVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDALIVHASRVQK 1191
                 ..|..::..:..|..|.| ::::...|...|.||:..:|||:|:||..|.|:|||:...:
Human   847 -----KSPDALESAQSEEEVDEL-SLIDHNEIMSRLTLKQEGDDGPDVRGGSGDILLVHATETDR 905

  Fly  1192 VADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDLTSTDL 1256
            .....:||||:||:||||.|.::|:||.:||..|.......|::.:|.||.:|||||::|...:|
Human   906 KDLVLYCEAFLTTYRTFISPEELIKKLQYRYEKFSPFADTFKKRVSKNTFFVLVRVVDELCLVEL 970

  Fly  1257 TSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYK--------EPKVYGFVGELGGAGSVG 1313
            |.::|.||:|.|::|||:|:|.||::||...::||...|        :|              :.
Human   971 TEEILKLLMELVFRLVCNGELSLARVLRKNILDKVDQKKLLRCATSSQP--------------LA 1021

  Fly  1314 GAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNL 1378
            ..|:|...|           :|.|..|.|||||:||||||||.|||||||||:||:|.|||||||
Human  1022 ARGVAARPG-----------TLHDFHSHEIAEQLTLLDAELFYKIEIPEVLLWAKEQNEEKSPNL 1075

  Fly  1379 NKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRL 1443
            .:||||||.||||.||.|:..:.|::||:.:.|||||||||||:||:|||||:||||||.|||||
Human  1076 TQFTEHFNNMSYWVRSIIMLQEKAQDRERLLLKFIKIMKHLRKLNNFNSYLAILSALDSAPIRRL 1140

  Fly  1444 EWQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVIN 1508
            ||||..:|.:..:|.||||||||||||.||:|..||||||:|||||||||||:||.||:. |.:|
Human  1141 EWQKQTSEGLAEYCTLIDSSSSFRAYRAALSEVEPPCIPYLGLILQDLTFVHLGNPDYID-GKVN 1204

  Fly  1509 FSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMGEEEMWQISEKIKPR 1564
            |||||||:||:|:|:.|::..|..|||:.||.||::|.|.:.||.:|::|.|||||
Human  1205 FSKRWQQFNILDSMRCFQQAHYDMRRNDDIINFFNDFSDHLAEEALWELSLKIKPR 1260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	58/143 (41%)
		RasGEF	1335..1558	CDD:238087	149/222 (67%)
RAPGEF1	XP_011516873.1	PHA03247	<237..495	CDD:223021	73/306 (24%)
		PHA03307	722..>893	CDD:223039	49/201 (24%)
		RasGEFN	884..1025	CDD:214571	58/154 (38%)
		RasGEF	1032..1261	CDD:214539	155/230 (67%)