DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C3G and RASGRP3

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001132960.1	Gene:	RASGRP3 / 25780	HGNCID:	14545	Length:	690	Species:	Homo sapiens

Alignment Length:	236	Identity:	59/236 - (25%)
Similarity:	116/236 - (49%)	Gaps:	6/236 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1338 LKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDA 1402
            |:.:|:||.:|.|:.:.|.:|...:...:....|.|.:|.|.:....||.:|.|.:..:|.....
Human   151 LEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPTP 215

  Fly  1403 KEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRL-EWQKGITEEV----RSFCALIDS 1462
            ::|.:.:.|||.:.|.|.::.|:|:.:|::..|....|.|| |....::.||    .....|:.|
Human   216 QQRAEVITKFINVAKKLLQLKNFNTLMAVVGGLSHSSISRLKETHSHLSSEVTKNWNEMTELVSS 280

  Fly  1463 SSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKK 1527
            :.::..||:|.|:.:...||.:|:.|:||..|||...|:..:..:|..|..|....:..:...:.
Human   281 NGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWTEENKVNIVKMHQLSVTLSELVSLQN 345

  Fly  1528 CAYPFRRNERIIRFFDNFKD-FMGEEEMWQISEKIKPRGRR 1567
            .::....|..:|.......| :..|::::::|..::||..:
Human   346 ASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSK 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	56/225 (25%)
RASGRP3	NP_001132960.1	REM	11..126	CDD:100121
		RasGEF	148..384	CDD:214539	58/232 (25%)
		EF-hand_7	428..478	CDD:316058
		C1	495..544	CDD:237996
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	667..690
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810