Protein Alignment C3G and efc25

DIOPT Version :10

• Sequence 1: NP_572350.2
• Gene: C3G / 31618
• FlyBaseID: FBgn0259228
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: NP_596123.1
• Gene: efc25 / 2540248
• PomBaseID: SPBC336.03
• Length: 987
• Species: Schizosaccharomyces pombe
• Alignment Length: 1120
• Identity: 209/1120 - (18%)
• Similarity: 344/1120 - (30%)
• Gaps: 423/1120 - (37%)

  Fly   721 SMREFRTST---QTTDYSVQS-----STKSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQR 777
            |.:.|.||.   .|..||..|     |.||..|.|.::.|.:.|:...:.|.||...
pombe    13 SRQGFETSVSKPSTPSYSTYSLSPTFSDKSVLSPSTMSDSYALSSTYTAGSSYQNGE-------- 69

  Fly   778 HISSSSSSCTTTTTSSSTTTGY----GS-----SEVEQLQQQQQQQTTTTP-------------- 819
              |....|..|.::..|:|:.:    ||     |....|.:|...::..||
pombe    70 --SDYFGSLPTPSSDKSSTSPFPYLKGSFDDRFSSTHSLTRQPSPRSPLTPLKGNTRASPEIRYV 132

  Fly   820 ADLAPALPPKSIQRSSLTRHDSPGVGDELDEVQSSSGWASHRSSQSEVAELRQLSPLHHLNHHP- 883
            :|..|...|....::|:  |..|..|..:..|:::...:...||.|.:.....|.|.....:.|
pombe   133 SDFTPPSSPFEDMQASV--HSLPLSGCSIGPVRTNHSSSLSNSSNSLLQTESSLRPNSSFVNSPF 195

  Fly   884 ------------------------------HTASA------------------------GQLQQW 894
                                          |..||                        .|...:
pombe   196 FPLPSSDDLFLNDRVINLFLFYEKFSYLFTHLLSAIKSRDALSIPSLVLSLQEELFNLCQQTGTF 260

  Fly   895 HSKHHSLIEG--------------------------------------PRLQLAG---------- 911
            :...|:|::.                                      ||||.:.
pombe   261 YLLQHNLLQNFEFENPIKLHFDKIIPYFSRLTVLTFSNRAFIFPDHTFPRLQQSAEDFLYHLQFF 325

  Fly   912 -----------------------------------SGSCSAFDQRHLDQEPPPLPIKKKHILAYM 941
                                               |...||:..|.|:   |.||...|.:...:
pombe   326 FTLCANNSLYLSRFCYYPSFVPNTPFGGKWTNNGLSAVSSAYRTRLLE---PCLPELDKCVWFLL 387

  Fly   942 EICSASTRSIEQHRHTMHACNISRNI-SHSQ---------TMNIMPMSKELSPELEMPPALPPKN 996
            :.|.....:........:...|...| |||:         .|:|. ..|:|| |.|.......::
pombe   388 KNCDEFIENFSDFADEEYVFEICSTITSHSEQIFNKLESWDMSIY-FDKDLS-ECEQATNFAVQS 450

  Fly   997 Y---KQR---KATSMVAS---------------PTLQPVIVTTPPPSPKPTLGENGSTGRPDSRM 1040
            |   |||   ..|.:|.|               ||:...|...     ..||.||
pombe   451 YFVTKQRCYDLLTDLVCSSQDLMMEHSNDFSTMPTMIASIAVA-----FQTLFEN---------- 500

  Fly  1041 ATVCEELNDAVASEDAMPEPRSPVLD---SNENVSAVDD-------GQTFYCHSHQLPAAEMEMS 1095
              ||:.|....|..|.|.|..:...:   ||.|.:..|:       |.|....|....|.. |||
pombe   501 --VCDFLKVRAALVDEMQELATKEFENKFSNANTAKDDEPARQTNKGTTRISRSSDFTAVS-EMS 562

  Fly  1096 EDASSADNQPITTPQVLEEQEEPTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITR 1160
            :|..:...                                               |.|:.:.:..
pombe   563 KDTLTLGR-----------------------------------------------NSLQSILMLD 580

  Fly  1161 YLILKKREEDGPEVKGGYIDALIVHASRVQKVADNA-FCEAFITTFRTFIQPIDVIEKLTHRYTY 1224
            .|:..|..:....||||.:.||:.:.  ||.|..|. |..:|:.|::||..|
pombe   581 NLLTNKVVQSDNNVKGGTLPALVHYL--VQNVHLNKDFRHSFLLTYKTFTTP------------- 630

  Fly  1225 FFCQVQDNKQKAAKETFALLVRVVNDLTSTDLTS-------------------QLLSLLVE--FV 1268
                         :|.|.|||.:.::|....|.:                   .:::|.|:  |.
pombe   631 -------------QELFTLLVILFHELPPPGLDATAYSSWEKGDNFVTKKNVCTVMNLWVQKYFF 682

  Fly  1269 YQLVCSGQLYLAKLLRNKFVEKVT----------------------------LYKEP-------K 1298
            ..|.....|||...:|....:.|.                            |...|       .
pombe   683 EDLKARNTLYLISEMRTFLRDHVVPSFHIGSVILSEIDNLWTEEPPDSLTQRLLSSPMATFISLN 747

  Fly  1299 VYGFVGELGGAGSVGGAGIAGSGGCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEV 1363
            ||.:..|                                    |.|.|||||:.:...:|...|
pombe   748 VYAYTPE------------------------------------EFASQMTLLEFDYLKQIPSRE- 775

  Fly  1364 LLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSY 1428
            .:|......:....:..:....|..:||..:.||..::.|.|...::.||:.......:.|:::.
pombe   776 WIFRSWVSRDSRSAVRNYINFSNCFTYWIINCILEKKNTKARTAVISFFIQTAYKCLSLQNFSTL 840

  Fly  1429 LALLSALDSGPIRRLEWQKGITEEVRSFC-----ALIDSSSSFRAYRQALAETNPPCIPYIGLIL 1488
            ::::|||:|.||.||.....:.:.....|     .::::..:|..||..|.:...||:|::|:||
pombe   841 MSIVSALNSAPIYRLHAAYKLVKAEDIICLSGLREIVETKKNFSTYRALLRKAELPCVPFLGVIL 905

  Fly  1489 QDLTFVHVGNQDYL--SKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMGE 1551
            .||||:..||.|.|  |..:::|:||.:..:::.::.||:..:|..:.|..:..:..:...|:.:
pombe   906 SDLTFIDEGNPDVLDSSPHLLSFNKRHRLADVVADVCRFQSSSYEMQSNTDLQSYILHRCRFVNQ 970

  Fly  1552 E--EMWQISEKIKPR 1564
            :  .::..|..::||
pombe   971 DLSYLFDKSLSLEPR 985

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	36/192 (19%)
		RasGEF	1335..1558	CDD:238087	56/231 (24%)
efc25	NP_596123.1	RasGEF_N	593..700	CDD:459873	31/134 (23%)
		RasGEF	755..932	CDD:459872	50/177 (28%)