DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C3G and Ralgps1

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_780420.1	Gene:	Ralgps1 / 241308	MGIID:	1922008	Length:	585	Species:	Mus musculus

Alignment Length:	250	Identity:	72/250 - (28%)
Similarity:	129/250 - (51%)	Gaps:	32/250 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1342 EIAEQMTLLDAELFTKIEIPEVLL---FAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAK 1403
            |.|.|:||:|..:|..|: ||.|.   ::|.:....:||:..||..||::|:|...:||..|..|
Mouse    53 EFASQITLMDIPVFKAIQ-PEELASCGWSKKEKHSLAPNVVAFTRRFNQVSFWVVREILTAQTLK 116

  Fly  1404 EREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRL--EW------QKGITEEVRSFCALI 1460
            .|.:.::.|:||.|.|.::||.:|.::::|||.|.||.||  .|      .|...|::....:..
Mouse   117 IRAEILSHFVKIAKKLLELNNLHSLMSVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLMSKE 181

  Fly  1461 DSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRF 1525
            |:....|.|.::|...  |.|||:|:.|.||.::   :..|.:.|.|  .:..|:.|.::|:.|.
Mouse   182 DNYKRTRDYIRSLKMV--PSIPYLGIYLLDLIYI---DSAYPASGSI--MENEQRSNQMNNILRI 239

  Fly  1526 -----KKCAYP-------FRRNERIIRFFDNFKDFMGEEEMWQISEKIKPRGRRP 1568
                 ..|:|.       .::..:.:|:.:..:.|: |::.:::|.:|:|....|
Mouse   240 IADLQVSCSYDHLTTLPHVQKYLKSVRYIEELQKFV-EDDNYKLSLRIEPGSSSP 293

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	68/238 (29%)
Ralgps1	NP_780420.1	RasGEF	46..288	CDD:214539	70/243 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	289..342		0/4 (0%)
		PXXP	330..333
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..410
		Required for stimulation of nucleotide exchange by RALA. /evidence=ECO:0000250	461..585
		PH_RalGPS1_2	461..576	CDD:270120
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810