DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C3G and Rasgrp3

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001159965.1	Gene:	Rasgrp3 / 240168	MGIID:	3028579	Length:	691	Species:	Mus musculus

Alignment Length:	236	Identity:	57/236 - (24%)
Similarity:	117/236 - (49%)	Gaps:	6/236 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly  1338 LKSLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDA 1402
            |:.:|:||.:|.|:.:.|.:|...:...:....|.|.:|.|.:....||.:|.|.:..:|....|
Mouse   151 LEPIELAEHLTFLEHKSFRRISFTDYQSYVIHGCLENNPTLERSIALFNGISKWVQLMVLSKPSA 215

  Fly  1403 KEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE-----WQKGITEEVRSFCALIDS 1462
            ::|.:.:.|||.:.:.|.::.|:|:.:|::..|....|.||:     ....:|:.......|:.|
Mouse   216 QQRAEVITKFINVAQKLLQLKNFNTLMAVVGGLSHSSISRLKDTHSHLSSEVTKNWNEMTELVSS 280

  Fly  1463 SSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKK 1527
            :.::..||:|.|:.:...||.:|:.|:||..|||...|::.:..:|..|..|....:..:...:.
Mouse   281 NGNYCNYRKAFADCDGFKIPILGVHLKDLIAVHVIFPDWMEENKVNVVKMHQLSVTLSELVSLQN 345

  Fly  1528 CAYPFRRNERIIRFFDNFKD-FMGEEEMWQISEKIKPRGRR 1567
            .::....|..:|.......| :..|::::::|..::||..:
Mouse   346 ASHHLEPNMDLINLLTLSLDLYHTEDDIYKLSLVLEPRNSK 386

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	54/225 (24%)
Rasgrp3	NP_001159965.1	REM	11..126	CDD:100121
		RasGEF	148..384	CDD:214539	56/232 (24%)
		EF-hand_7	428..478	CDD:372618
		C1	495..544	CDD:237996
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810