Protein Alignment C3G and Sos2

DIOPT Version :9

• Sequence 1: NP_572350.2
• Gene: C3G / 31618
• FlyBaseID: FBgn0259228
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: XP_006515698.1
• Gene: Sos2 / 20663
• MGIID: 98355
• Length: 1333
• Species: Mus musculus
• Alignment Length: 574
• Identity: 133/574 - (23%)
• Similarity: 238/574 - (41%)
• Gaps: 139/574 - (24%)

  Fly  1081 YCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEEPTAESRPLVAVH-ESVKPANVD------ 1138
            |.|:.:|      :|:|    :|..|...:..||:....|   .|:::| .|.....:|
Mouse   509 YRHAFEL------VSKD----ENSVIFAAKSAEEKNNWMA---ALISLHYRSTLDRMLDSVLLKE 560

  Fly  1139 EDEEAERADMLINMLEEVNITRYLILKKRE----EDG-------PEVKGGYIDALIVHASRVQKV 1192
            |:|:..|       |...::.|:::....|    ||.       |.:|||.:..||...: ....
Mouse   561 ENEQPLR-------LPSPDMYRFVVTDSEENIVFEDNLQSRSGIPIIKGGTVVKLIERLT-YHMY 617

  Fly  1193 ADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDLTSTDLT 1257
            ||..|...|:||:|:|.:|.:::..|..|:        :..:....|...|.:.......|.||
Mouse   618 ADPNFVRTFLTTYRSFCKPQELLNLLIERF--------EIPEPEPTEADKLALEKGEQPISADL- 673

  Fly  1258 SQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTL--------YKEPKVYGFVGEL-------G 1307
                                   |..|.::|:.|.|        :.|...|.|..:|       .
Mouse   674 -----------------------KRFRKEYVQPVQLRVLNVFRHWVEHHYYDFERDLELLERLES 715

  Fly  1308 GAGSVGGAGI----------------AGSGGCSGTAGGGNQP----------------SLLDLKS 1340
            ...||.|..:                |.:.|.|......:.|                .|:.|..
Mouse   716 FISSVRGKAMKKWVESIAKIIKRKKQAQANGISHNITFESSPPPVEWHISRTGQFETFDLMTLHP 780

  Fly  1341 LEIAEQMTLLDAELFTKIEIPEVL--LFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAK 1403
            :|||.|:|||:::|:.|::..|::  ::.|:..|..||||.|...|...::.|....|:..::.:
Mouse   781 IEIARQLTLLESDLYRKVQPSELVGSVWTKEDKEINSPNLLKMIRHTTNLTLWFEKCIVEAENFE 845

  Fly  1404 EREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLEWQ-KGITEEVRSFCALID-----S 1462
            ||...:::.::|::..:.:||:|..|.::||::|..:.||:.. :.:.|..|   .::|     |
Mouse   846 ERVAVLSRIVEILQVFQDLNNFNGVLEIVSAVNSVSVYRLDHTFEALQERKR---RILDDAVELS 907

  Fly  1463 SSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYL---SKGVINFSKRWQQYNIIDNMKR 1524
            ...|:.|...|...||||:|:.|:.|.::.....||.|:|   .|.:||||||.:...|...:::
Mouse   908 QDHFKKYLVKLKSINPPCVPFFGIYLTNILKTEEGNSDFLKRKGKDLINFSKRRKVAEITGEIQQ 972

  Fly  1525 FKKCAYPFRRNERIIRFFDNFK--DFMGEEE----MWQISEKIKPRG-RRPVNY 1571
            ::...|..|....:.|||:|..  ..:.|:|    ::..|.:|:||. ::|..:
Mouse   973 YQNQPYCLRTEPEMRRFFENLNPMGILSEKEFTDYLFNKSLEIEPRNCKQPPRF 1026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	31/150 (21%)
		RasGEF	1335..1558	CDD:238087	68/239 (28%)
Sos2	XP_006515698.1	Histone	70..169	CDD:333859
		RhoGEF	200..387	CDD:238091
		PH_SOS	438..544	CDD:269963	11/47 (23%)
		RasGEFN	596..740	CDD:214571	34/176 (19%)
		RasGEF	775..1019	CDD:214539	71/246 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840