DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C3G and Sos1

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_033257.2	Gene:	Sos1 / 20662	MGIID:	98354	Length:	1319	Species:	Mus musculus

Alignment Length:	851	Identity:	190/851 - (22%)
Similarity:	331/851 - (38%)	Gaps:	226/851 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   842 PGVGDELDEVQSSSGWASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQWHSKHHSLIEG-- 904
            |.||...:::.....:..:.|...::  ||.....|.|:......:|..||       |:.||
Mouse   277 PLVGSCFEDLAEELAFDPYESYARDI--LRPGFHGHFLSQLSKPGAALYLQ-------SIGEGFK 332

  Fly   905 -------PRLQLAGSGSC-------SAFDQRHLDQEPPPLPIKKKHILAYM-------EICSAST 948
                   |||.||....|       ...:::..|||..  ...|:.|.|.:       :|||
Mouse   333 EAVQYVLPRLLLAPVYHCLHYFELLKQLEEKSEDQEDK--ECMKQAITALLNVQSGMEKICS--- 392

  Fly   949 RSIEQHRHTMHACNISRNISHSQTMNIMPMSKELSPELEMPPALPPKNYKQRK------------ 1001
            :|:.:.|.:..||..     :||.|.    .|:|        |:...|..|:.
Mouse   393 KSLAKRRLSESACRF-----YSQQMK----GKQL--------AIKKMNEIQKNIDGWEGKDIGQC 440

  Fly  1002 ATSMVASPTLQPVIVTTPPPSPKPTLGENGSTGRPDSRMATVCEELNDAVASEDAMPEPRSPVLD 1066
            ....:...||..|                   |....|...:.:.|  .:..:....:||.|...
Mouse   441 CNEFIMEGTLTRV-------------------GAKHERHIFLFDGL--MICCKSNHGQPRLPGAS 484

  Fly  1067 SNE----------NVSAVD-DGQTFYCHSHQL------------PAAEMEMSEDASSADNQPITT 1108
            |.|          .|...| |..:.|.|:.::            .:||.:.:..|:....|..:|
Mouse   485 SAEYRLKEKFFMRKVQINDKDDTSEYKHAFEIILKDGNSVIFSAKSAEEKNNWMAALISLQYRST 549

  Fly  1109 PQ------VLEEQEE-----PTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYL 1162
            .:      ||:|::|     |:||      |:...:|   |.:|         |:|.|.|:
Mouse   550 LERMLDVTVLQEEKEEQMRLPSAE------VYRFAEP---DSEE---------NILFEENV---- 592

  Fly  1163 ILKKREEDG-PEVKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFF 1226
                :.:.| |.:|.|.:..||...: ....||..|...|:||:|:|.:|.:::..|..|:
Mouse   593 ----QPKAGIPIIKAGTVLKLIERLT-YHMYADPNFVRTFLTTYRSFCRPQELLSLLIERF---- 648

  Fly  1227 CQVQDNKQKAAKETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRN------ 1285
             ::.:.:...|.       |:..:.....|:::|.....|::..:    ||.:..:.|:
Mouse   649 -EIPEPEPTEAD-------RIAIENGDQPLSAELKRFRKEYIQPV----QLRVLNVCRHWVEHHF 701

  Fly  1286 -KFVEKVTLYKEPKVYGFVGELGGAGS----------VGGAGIAGSGGCSGTAGGGNQP------ 1333
             .|.....|.:  ::..|:|.:.|...          :....||...|........:.|
Mouse   702 YDFERDADLLQ--RMEEFIGTVRGKAMKKWVESITKIIQRKKIARDNGPGHNITFQSSPPTVEWH 764

  Fly  1334 ----------SLLDLKSLEIAEQMTLLDAELFTKIEIPEVL--LFAKDQCEEKSPNLNKFTEHFN 1386
                      .||.|..:|||.|:|||:::|:..::..|::  ::.|:..|..||||.|...|..
Mouse   765 ISRPGHIETFDLLTLHPIEIARQLTLLESDLYRAVQPSELVGSVWTKEDKEINSPNLLKMIRHTT 829

  Fly  1387 KMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLEW------ 1445
            .::.|....|:..::.:||...|::.|:|::..:::||:|..|.::||::|.|:.||:.
Mouse   830 NLTLWFEKCIVETENLEERVAVVSRIIEILQVFQELNNFNGVLEVVSAMNSSPVYRLDHTFEQIP 894

  Fly  1446 --QKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYL---SKG 1505
              ||.|.||....     |...::.|...|...||||:|:.|:.|.::.....||.:.|   .|.
Mouse   895 SRQKKILEEAHEL-----SEDHYKKYLAKLRSINPPCVPFFGIYLTNILKTEEGNPEVLRRHGKE 954

  Fly  1506 VINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMG---EEE----MWQISEKIKP 1563
            :||||||.:...|...:::::...|..|....|.|||:|... ||   |:|    ::..|.:|:|
Mouse   955 LINFSKRRRVAEITGEIQQYQNQPYCLRVEPDIKRFFENLNP-MGNSMEKEFTDYLFNKSLEIEP 1018

  Fly  1564 RGRRPV 1569
            |..:|:
Mouse  1019 RHPKPL 1024

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	29/143 (20%)
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	74/242 (31%)
Sos1	NP_033257.2	H2A	97..177	CDD:305064
		RhoGEF	204..389	CDD:214619	26/122 (21%)
		PH_SOS	439..545	CDD:269963	19/126 (15%)
		PH	445..546	CDD:278594	19/121 (16%)
		RasGEFN	597..741	CDD:214571	30/162 (19%)
		RasGEF	776..1015	CDD:238087	75/244 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1019..1101		2/6 (33%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1121..1319
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.840