DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C3G and Rasgrf2

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_036013814.1	Gene:	Rasgrf2 / 19418	MGIID:	109137	Length:	1190	Species:	Mus musculus

Alignment Length:	511	Identity:	126/511 - (24%)
Similarity:	212/511 - (41%)	Gaps:	130/511 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly  1099 SSADNQPITTPQVLEEQEEPTAESRP-LVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYL 1162
            ||:.:.|.||      ...|.|...| ..||.||. ||    |:..:.|||  :........|:
Mouse   762 SSSSSSPTTT------THSPAASPPPHTAAVLESA-PA----DKAGDSADM--SPCRSPTTPRH- 812

  Fly  1163 ILKKREEDGPEVKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLT----HRYT 1223
             |:.|:..|                   :|||:|.|.         :.|.......|    |...
Mouse   813 -LRYRQPGG-------------------QVADSAHCS---------VSPASAFAIATAAAGHGSP 848

  Fly  1224 YFFCQVQDNKQKAAKETFAL----LVRVVNDL------------TSTDLTSQLLSLLVEFVY--Q 1270
            ..|     |.::...:.|.:    ..||:|.|            .:.:|...:|:||.|.:.  .
Mouse   849 PGF-----NNERTCDKEFIIRRTATNRVLNVLRHWVSKHAQDFELNNELKMNVLNLLEEVLRDPD 908

  Fly  1271 LVCSGQLYLAKLLRN-----------KFVEKVTLYKEPKVYGFVGELGGAGSVGGAGIAGSGGCS 1324
            |:...:...|.:||.           |..:.:.:...||                      ..|.
Mouse   909 LLPQERKATANILRALSQDDQDDIHLKLEDIIQMTDCPK----------------------AECF 951

  Fly  1325 GTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVL--LFAKDQCEEKSPNLNKFTEHFNK 1387
            .|           |.::|:|||:||||..:|..|...|.|  .:.|....|::|.:.|.::|||:
Mouse   952 ET-----------LSAMELAEQITLLDHIVFRSIPYEEFLGQGWMKLDKNERTPYIMKTSQHFNE 1005

  Fly  1388 MSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE--WQKGIT 1450
            ||....|:|:...|...|...:.|::.:....|.::|||..|.:.|||:...|.||:  |.| ::
Mouse  1006 MSNLVASQIMNYADISSRANAIEKWVAVADICRCLHNYNGVLEITSALNRSAIYRLKKTWAK-VS 1069

  Fly  1451 EEVRSFCALID-------SSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVIN 1508
            ::.:   ||:|       |...|:..|:.|...|||.:||:|:.|.||.|:..|..::..:|::|
Mouse  1070 KQTK---ALMDKLQKTVSSEGRFKNLRETLKNCNPPAVPYLGMYLTDLAFIEEGTPNFTEEGLVN 1131

  Fly  1509 FSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMGEEEMWQISEKIKPR 1564
            |||.....:||..:::|::.||...:..::|::..:....:.|:.::::|.||:||
Mouse  1132 FSKMRMISHIIREIRQFQQTAYRIDQQPKVIQYLLDKALVIDEDSLYELSLKIEPR 1187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	28/168 (17%)
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	70/233 (30%)
Rasgrf2	XP_036013814.1	PH_RasGRF1_2	19..158	CDD:270081
		RhoGEF	247..428	CDD:214619
		PH	480..588	CDD:214574
		RasGEF_N	638..>686	CDD:395493
		REM	<853..925	CDD:413353	14/71 (20%)
		RasGEF	951..1187	CDD:214539	74/250 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940