DRSC/TRiP Functional Genomics Resources

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Protein Alignment C3G and Rasgrf1

DIOPT Version :9

Sequence 1:NP_572350.2 Gene:C3G / 31618 FlyBaseID:FBgn0259228 Length:1571 Species:Drosophila melanogaster
Sequence 2:NP_035375.1 Gene:Rasgrf1 / 19417 MGIID:99694 Length:1262 Species:Mus musculus


Alignment Length:1356 Identity:254/1356 - (18%)
Similarity:439/1356 - (32%) Gaps:474/1356 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly   530 DTSPPP------KPPLPNRASNPPPLPPKRRSQPSASAGTVGVGCSSSTSTSNQASPLPYAQSHN 588
            |:||.|      :..:..||.:     |||             |.||..|...        |.|.
Mouse    57 DSSPRPSGLYLLEGSICKRAPS-----PKR-------------GTSSKESGEK--------QQHY 95

  Fly   589 ISLNSDLDCSSNISLLNYGVDRLSVRSRSPDENSQCSFDSALNH------SREEEDQQQQHQHL- 646
            .::|...|....:.|            |:.|......:.:|:..      :.|.|...|::.|| 
Mouse    96 FTVNFSNDSQKTLEL------------RTEDAKDCDEWVAAIARASYKILATEHEALMQKYLHLL 148

  Fly   647 ------RSFPKLAAMMDED-------MDKMVSYSAAIDDKTQTPLSTGGGIAGVAGGTGGAGEGV 698
                  ::..|......||       :...|:.:..|.|..:...|...|               
Mouse   149 QVVETEKTVAKQLRQQLEDGEVEIERLKTEVTITNLIKDNDRIQSSNKAG--------------- 198

  Fly   699 AAAASGDGETNSNR-----HSNESGFVSMREFRTSTQTTDYSVQSSTKSSSSNSEIAFSISESTA 758
                |.|.|.:..:     .|...|::..|:::...|  ||.......|....:::.||:.|:.|
Mouse   199 ----SADDEDSDIKKIKKVQSFLRGWLCRRKWKNIIQ--DYIRSPHADSMRKRNQVVFSMLEAEA 257

  Fly   759 VGSSSEY-QQISQLVSHSQRHISSSSSSCTTTTTSSSTTTGYGSSEV---------EQLQQQQQQ 813
                 || ||:..||::..|.:..::||.....|....::.:.:||.         :.|:.:...
Mouse   258 -----EYVQQLHILVNNFLRPLRMAASSKKPPITHDDVSSIFLNSETIMFLHQIFYQGLKARISS 317

  Fly   814 QTTTTPADLAPALPPK------------------------------------------------- 829
            ..|...|||...|.|.                                                 
Mouse   318 WPTLVLADLFDILLPMLNIYQEFVRNHQYSLQILAHCKQNRDFDKLLKQYEAKPDCEERTLETFL 382

  Fly   830 -----SIQRSSLTRHD-----------------SPGVGDEL-----DEVQSSSGWASHRSSQSEV 867
                 .|.|..||.|:                 :....:||     |||..:.....:.:.:..:
Mouse   383 TYPMFQIPRYILTLHELLAHTPHEHVERNSLDYAKSKLEELSRIMHDEVSETENIRKNLAIERMI 447

  Fly   868 AE------------LRQLSPLHHLNHHPHTASAGQLQQWHSK-----------HHSLI----EGP 905
            .|            :||.|.:.........:|.|:|....:|           .|.:|    .|.
Mouse   448 TEGCEILLDTSQTFVRQGSLMQMSLSEKSKSSRGRLGSLSTKKEGERQCFLFSKHLIICTRGSGG 512

  Fly   906 RLQLAGSG-----SCSAFDQ-RHLDQEPP-----------PLPIKKKHILAYMEICSASTR---- 949
            :|.|..:|     .|:..|: .:||.|..           .:.::.|..|.:..|..||||    
Mouse   513 KLHLTKNGVISLIDCTLLDEPENLDDEAKGAGPEIEHLEFKIGVEPKDSLPFTVILVASTRQEKA 577

  Fly   950 ---------------------SIEQH------------------------RHTMHACNISR---- 965
                                 :.|::                        ..||::|.:.:    
Mouse   578 AWTSDIIQCVDNIRCNGLMMNAFEENSKVTVPQMIKSDASLYCDDVDIRFSKTMNSCKVLQIRYA 642

  Fly   966 ---------------------NISHSQTM--NIMPMSKELSPELEMP-PALPPKNY--------- 997
                                 ...||..:  |.|.:..:|......| .|:|.::.         
Mouse   643 SVERLLERLTDLRFLSIDFLNTFLHSYRVFTNAMVVLDKLINIYRKPMSAIPARSLELLFSSSHN 707

  Fly   998 ---------KQRKATSMVASPTLQPVIVTTPPPSPKPTLGENGS--TGRPDSRMATV-CEELNDA 1050
                     |..:|:...:||  .|:.:.|..||.:..|..|..  ||.....:|:: |      
Mouse   708 AKLLYGDAPKSPRASRKFSSP--PPLAIGTSSPSRRRKLSLNIPIITGGKALELASLGC------ 764

  Fly  1051 VASEDAMPEPRSPVLDSNENVSAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQ 1115
              |.|:.....||:  |....:.:|.|:  .|.:..||....|            |..|..:.|:
Mouse   765 --SSDSYANIHSPI--SPFGKTTLDTGK--LCMASSLPKTPEE------------IDVPATIPEK 811

  Fly  1116 EEPTAESRPL---VAVHESVKPANVDEDEEAERA------------------------------- 1146
            ....:.||..   |...||....|..:::..|.:                               
Mouse   812 PGELSASRKHSSDVLKEESEDDQNHSDEDNTEVSPVKSPPTPKSFLNRTITEFPFFNYNNGILMT 876

  Fly  1147 ---DMLINMLEEVNIT-RYLILKKREEDGPEVKGGY----------------IDALIVHASRVQK 1191
               |::.|....::.| .:.|......:||..|..:                ||...|    :::
Mouse   877 TCRDLVDNNRSTLSATSAFAIATAGANEGPSNKEVFRRMSLANTGFSSDQRNIDKEFV----IRR 937

  Fly  1192 VADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAAKETFALLVRVVNDLTSTDL 1256
            .|.|..............|..|..:.|.:|...|..:|..:.....:|..| ...::..||..:.
Mouse   938 AATNRVLNVLRHWVTKHTQDFDTDDTLKYRVICFLEEVMHDPDLLTQERKA-AANIIRTLTLEET 1001

  Fly  1257 TSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKVYGFVGELGGAGSVGGAGIAGSG 1321
            |.|                         :..:|:|.|..|                   |:.   
Mouse  1002 TEQ-------------------------HSMLEEVILMTE-------------------GVK--- 1019

  Fly  1322 GCSGTAGGGNQPSLLDLKSLEIAEQMTLLDAELFTKIEIPEVL--LFAKDQCEEKSPNLNKFTEH 1384
                |....|.|      :||||||:||||..:|..|...|..  .:.|.:..|::|.:.|.|:|
Mouse  1020 ----TEPFENHP------ALEIAEQLTLLDHLVFKSIPYEEFFGQGWMKAEKYERTPYIMKTTKH 1074

  Fly  1385 FNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE--WQK 1447
            ||.:|.:..|:|:|.:|...|...:.|::.:....|.::|||:.|.:.|:::...|.||:  |.|
Mouse  1075 FNHVSNFIASEIIRNEDISARASAIEKWVAVADICRCLHNYNAVLEITSSINRSAIFRLKKTWLK 1139

  Fly  1448 GITEEVRSFC----ALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVIN 1508
             ::::.:|..    .|:.|...|:..|::|...:|||:||:|:.|.||.|:..|..:|...|::|
Mouse  1140 -VSKQTKSLLDKLQKLVSSDGRFKNLRESLRNCDPPCVPYLGMYLTDLVFIEEGTPNYTEDGLVN 1203

  Fly  1509 FSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMGEEEMWQISEKIKPR 1564
            |||.....:||..:::|::..|......::|::..:....:.||.:::.|..|:|:
Mouse  1204 FSKMRMISHIIREIRQFQQTTYKIDPQPKVIQYLLDESFMLDEESLYESSLLIEPK 1259

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C3GNP_572350.2 RasGEFN 1170..1306 CDD:214571 24/151 (16%)
RasGEF 1335..1558 CDD:238087 69/230 (30%)
Rasgrf1NP_035375.1 PH-like 19..155 CDD:302622 26/135 (19%)
PH 24..130 CDD:278594 21/110 (19%)
RhoGEF 248..429 CDD:214619 30/185 (16%)
PH-like 435..586 CDD:302622 26/150 (17%)
PH 482..587 CDD:278594 20/104 (19%)
RasGEF_N 638..>687 CDD:279012 5/48 (10%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 714..738 6/25 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 800..854 11/65 (17%)
REM <927..996 CDD:295342 13/73 (18%)
RasGEF 1023..1259 CDD:214539 73/242 (30%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R2063
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
32.840

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