DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment C3G and Y34B4A.4

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001024958.1	Gene:	Y34B4A.4 / 180798	WormBaseID:	WBGene00021320	Length:	877	Species:	Caenorhabditis elegans

Alignment Length:	1056	Identity:	261/1056 - (24%)
Similarity:	448/1056 - (42%)	Gaps:	257/1056 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   569 SSSTST---SNQASPLPYAQSHNISLNSDLDCSSNISL---------LNYGVDRLSVRSRSPDEN 621
            |::.||   |:.|:.|.....:..:.|.:|. .|.|||         ||..||...::. |..|.
Worm    17 STNNSTLILSSTAAVLEAVSKNCDTTNGELK-RSIISLLRIIDKKCFLNQDVDVNQIKF-SLQEV 79

  Fly   622 SQCSFDSALNHSRE-EEDQQQQHQHLRSFPKLAAMMDEDMD---------KMVSYSAAIDDKTQT 676
            .:.|.....:|.:. .|.:.:.:...|....:....:|::|         |:.|:|.|..|
Worm    80 GKLSTKYPKSHQKPGNEVKVKTNAEFREIETVPNPDEENIDNLLNQLNLKKVPSFSPAFPD---- 140

  Fly   677 PLSTGGGIAGVAGGTGGAGEGVAAAASGDGETNSNRHSN---ESGFVSM---REFRTSTQTTDYS 735
                       .|.......|:.....  .|..:.:|..   |...|.:   ||.|.. :|...:
Worm   141 -----------IGDDSDDENGITTKQK--EEERAEQHGQKVCEEEVVKLPDGREIRMK-KTKTVN 191

  Fly   736 VQSSTKSSSSNSEIAFSISESTAVGSSSEYQQISQLVSHSQRHISSSSSSCTTTTTSSSTTTGYG 800
            |:.:||          .::.||   .|:...::|:...:::|..........|...||:...|..
Worm   192 VKQTTK----------HVTIST---KSANMPEVSRTFMNARRGFDEDEEEENTNFGSSNMRGGDP 243

  Fly   801 SSEVEQLQQQQQQ-------QTTTTPADLAPALPPKSIQRSSLTRHDSPGVGDELDEVQSSSG-- 856
            ......:.:.:.:       ::::.|.....:...|:|:|:|       .|..::.|.:...|
Worm   244 FERFRSMLKDKDEKIEAIEGESSSDPGTPGSSSKSKTIERTS-------EVSQKVSEKKEKDGRL 301

  Fly   857 WASHRSSQSEVAELRQLSPLHHLNHHPHTASAGQLQQWHSKHHSLIEGPRL-QLAGSGSC----- 915
            .|.|.:|:.:.:.|                        .:|.....:|..| ...|.||.
Worm   302 LAEHEASKLDKSNL------------------------FAKQVDTYQGAALIDRKGEGSYEESTL 342

  Fly   916 --SAFDQRHLDQEPPPLPIKKKHILAYMEICSASTRSIEQHRHTMHACNISRNISHSQTMNIMPM 978
              ||..|......||     :.|::.||.:.....::.|.
Worm   343 VRSALPQDSQVATPP-----RMHVVEYMMMFGDDKKNNEN------------------------- 377

  Fly   979 SKELSPELEMPPALPPKNYKQRKATSMVASPTLQPVIVTTPPPSPKPTLGENGSTGRPDSRMATV 1043
                               :..|.|::                         .|..|.::.:.|.
Worm   378 -------------------EYLKGTTI-------------------------SSYVRLNNNLTTH 398

  Fly  1044 CEELNDAVASEDAMPEPRSPVLDSNENVSAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQP--I 1106
            .|:....:..|.:.....|..:|. :|:|.:.:...|.|           :.......::.|  :
Worm   399 EEQFKKKIQFEFSTAGTSSTTIDL-DNLSDLLNQTDFNC-----------LRPPNKFLEDTPLIV 451

  Fly  1107 TTPQVLEEQEEPTA--ESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREE 1169
            ..|:.::.|.|||:  ..:.|:..|:.|.                           |:|.:::|.
Worm   452 EQPKAIDWQREPTSAPPEKDLLLEHDGVD---------------------------YVIFREKEG 489

  Fly  1170 DGPEVKGGYIDALIVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQ 1234
            ...||:||..|||||:|:: ...:...:.|||:.||||||..::::.||..||.|.........:
Worm   490 KVLEVRGGPKDALIVYATQ-STHSSLLYQEAFLITFRTFISSLELVNKLIKRYLYMSLADDSQSE 553

  Fly  1235 KAAKETFALLVRVVNDLTSTDLTSQLLSLLVEFVYQLVCSGQLYLAKLLRNKFVEKVTLYKEPKV 1299
            ..|:.||:::||::::.|..:|...|::.:..|||:|:..|....:::||.:.::::
Worm   554 SIARHTFSVIVRIIDETTQYELDFDLITSVTSFVYRLIHDGNFTYSRILRTRLLDRI-------- 610

  Fly  1300 YGFVGELGGAGSVGGAGIAGSGGCSGTAGGGNQP-SLLDLKSLEIAEQMTLLDAELFTKIEIPEV 1363
                     ..|.....:.|:..|.     ..:| .|.|.||.|||.|:|.:|::|:.:||..|:
Worm   611 ---------KDSFDIQTVLGTNLCK-----PRKPHDLFDFKSAEIACQLTFIDSQLYHRIESAEL 661

  Fly  1364 LLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIMKHLRKMNNYNSY 1428
            |.:|::|.|:||.||..|||.||.:|:|.|:.|:.....||||:|:.||:|||||||:|.|:|||
Worm   662 LWWAQEQNEKKSKNLVNFTEQFNNLSFWVRTLIITQGTQKERERHMMKFVKIMKHLREMCNFNSY 726

  Fly  1429 LALLSALDSGPIRRLEWQKGITEEVRSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTF 1493
            ||:|||:.|.|:.||||.|.|.:.::...|::|::.|::.||..|....|||:||||:|||||||
Worm   727 LAILSAIMSTPLARLEWSKNIKDALKEHTAVMDTAQSYKNYRALLQTAKPPCVPYIGIILQDLTF 791

  Fly  1494 VHVGNQDYL-------SKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRFFDNFKDFMGE 1551
            ||.||.|.:       :|.:|||.|||.|:.|:|::::.||..|..::|:.::::|:.|||.:.|
Worm   792 VHAGNPDTIPSDRCHGAKNMINFLKRWNQFAILDSIRKLKKWNYDIKKNDIVVQYFNGFKDCIDE 856

  Fly  1552 EEMWQISEKIKPRGRR 1567
            |..||:|.:|||..|:
Worm   857 ERTWQLSHQIKPSNRK 872

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	39/135 (29%)
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	110/229 (48%)
Y34B4A.4	NP_001024958.1	REM	499..612	CDD:100121	35/130 (27%)
Y34B4A.4	NP_001024958.1	RasGEF	640..818	CDD:279011	89/177 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160161787
Domainoid	1	1.000	186	1.000	Domainoid score	I1995
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0006253
OrthoInspector	1	1.000	-	-		oto20692
orthoMCL	1	0.900	-	-		OOG6_106476
Panther	1	1.100	-	-	LDO	PTHR23113
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2063
SonicParanoid	1	1.000	-	-		X3984
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	9	8.870