Protein Alignment C3G and Rasgrp4

DIOPT Version :10

• Sequence 1: NP_572350.2
• Gene: C3G / 31618
• FlyBaseID: FBgn0259228
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: XP_038939950.1
• Gene: Rasgrp4 / 170668
• RGDID: 620476
• Length: 726
• Species: Rattus norvegicus
• Alignment Length: 349
• Identity: 80/349 - (22%)
• Similarity: 147/349 - (42%)
• Gaps: 44/349 - (12%)

  Fly  1251 LTSTDLTSQLLSLLVEFVYQLVCSG-----QLYLAKLLRNKFV-EKVTLYKEPKVYGFVG----- 1304
            |.|:||.::||:     .||.....     ||.:..|:|.... ....:::||::...:.
  Rat   141 LPSSDLAARLLT-----SYQKAAKDARELRQLQICYLVRYWLTHHPEVVHQEPQLEAIINRFWTT 200

  Fly  1305 ----------ELGGAG---SVGGAG---IAGSGGCSGTAGGGNQPSLL--DLKSLEIAEQMTLLD 1351
                      .||.|.   |.||.|   :..|.|    .|...:.|||  .|::.|:|:.:|.|:
  Rat   201 VAQEGNMAQRSLGDASNLLSPGGPGPPPLMSSPG----LGKKRKVSLLFDHLETEELAQHLTYLE 261

  Fly  1352 AELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKIM 1416
            ...|..|...::..:.........|.|.......|.:|.|.:..:|......:|.:.::|||::.
  Rat   262 FRSFQAITPQDLRGYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPAQRAQVLDKFIRVA 326

  Fly  1417 KHLRKMNNYNSYLALLSALDSGPIRRLE-----WQKGITEEVRSFCALIDSSSSFRAYRQALAET 1476
            :.||:|.|:|:.:|:...|....|.||:     .....|:.:.....|:.|.:::..||:..|..
  Rat   327 QRLRQMQNFNTLMAVTGGLCHSAISRLKDSHVHLSPDSTKALLELTELLSSHNNYAYYRRTWASC 391

  Fly  1477 NPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIRF 1541
            ....:|.:|:.|:||..::..:.|.|..|.::..|....|..:..:...::...|...||.::..
  Rat   392 TDFRLPVLGVHLKDLVSLYEAHPDRLPDGRLHLPKLNSLYLRLQELAALQRQHPPCSANEDLLHL 456

  Fly  1542 FDNFKD-FMGEEEMWQISEKIKPR 1564
            .....| |..|:|::::|...:||
  Rat   457 LTLSLDLFYTEDEIYELSYAREPR 480

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	14/75 (19%)
		RasGEF	1335..1558	CDD:238087	52/230 (23%)
Rasgrp4	XP_038939950.1	REM	105..220	CDD:100121	17/83 (20%)
		RasGEF	245..480	CDD:214539	51/234 (22%)
		C1	586..647	CDD:412127