DRSC/TRiP Functional Genomics Resources

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Protein Alignment C3G and RASGRP4

DIOPT Version :9

Sequence 1:NP_572350.2 Gene:C3G / 31618 FlyBaseID:FBgn0259228 Length:1571 Species:Drosophila melanogaster
Sequence 2:NP_733749.1 Gene:RASGRP4 / 115727 HGNCID:18958 Length:673 Species:Homo sapiens


Alignment Length:350 Identity:76/350 - (21%)
Similarity:144/350 - (41%) Gaps:46/350 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly  1251 LTSTDLTSQLLSLLVEFVYQLVCSG-----QLYLAKLLRNKFV-EKVTLYKEPKVYGFVG----- 1304
            |.|.||.::||:     .||.....     :|.:..|:|...: ....::::|::...:|     
Human    93 LPSADLAARLLT-----SYQKATGDTQELRRLQICHLVRYWLMRHPEVMHQDPQLEEVIGRFWAT 152

  Fly  1305 ----------ELGGAG---SVGGAG----IAGSGGCSGTAGGGNQPSLL--DLKSLEIAEQMTLL 1350
                      .||.:.   |.||.|    ::..|     .|...:.|||  .|::.|:|:.:|.|
Human   153 VAREGNSAQRRLGDSSDLLSPGGPGPPLPMSSPG-----L
GKKRKVSLLFDHLETGELAQHLTYL 212

  Fly  1351 DAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREKHVNKFIKI 1415
            :...|..|...::..:.........|.|.......|.:|.|.:..:|......:|.:.::|||.:
Human   213 EFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQVMVLSRPGPLQRAQVLDKFIHV 277

  Fly  1416 MKHLRKMNNYNSYLALLSALDSGPIRRLE-----WQKGITEEVRSFCALIDSSSSFRAYRQALAE 1475
            .:.|.::.|:|:.:|:...|....|.||:     .....|:.:.....|:.|.:::..||:..|.
Human   278 AQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKALLELTELLASHNNYARYRRTWAG 342

  Fly  1476 TNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAYPFRRNERIIR 1540
            .....:|.:|:.|:||..:|....|.|..|.::..|....|..:..:...:....|...||.::.
Human   343 CAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLRLQELVALQGQHPPCSANEDLLH 407

  Fly  1541 FFDNFKD-FMGEEEMWQISEKIKPR 1564
            ......| |..|:|::::|...:||
Human   408 LLTLSLDLFYTEDEIYELSYAREPR 432

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
C3GNP_572350.2 RasGEFN 1170..1306 CDD:214571 13/75 (17%)
RasGEF 1335..1558 CDD:238087 51/230 (22%)
RASGRP4NP_733749.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..30
REM 57..164 CDD:100121 13/75 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 160..187 7/31 (23%)
RasGEF 197..432 CDD:214539 50/234 (21%)
C1 541..590 CDD:197519
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 593..621
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 639..673
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG3417
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
21.810

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