Protein Alignment C3G and RASGRP1

DIOPT Version :10

• Sequence 1: NP_572350.2
• Gene: C3G / 31618
• FlyBaseID: FBgn0259228
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: XP_047288029.1
• Gene: RASGRP1 / 10125
• HGNCID: 9878
• Length: 826
• Species: Homo sapiens
• Alignment Length: 493
• Identity: 104/493 - (21%)
• Similarity: 193/493 - (39%)
• Gaps: 96/493 - (19%)

  Fly  1111 VLEEQEEPTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDGPEVK 1175
            :|....:|:...|.........||||.........|          :||::.::...   |...|
Human    36 LLSFPRKPSHGCRAASKARLEAKPANSPFPSHPSLA----------HITQFRMMVSL---GHLAK 87

  Fly  1176 GGYIDALIVHASRVQKV-ADNAFC------EAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNK 1233
            |..:|.||  .|.:|.. ||...|      :..:|..|..|...::::|:...|          |
Human    88 GASLDDLI--DSCIQSFDADGNLCRSNQLLQVMLTMHRIVISSAELLQKVITLY----------K 140

  Fly  1234 QKAAKETFALLVRVV---------------NDLTSTDLTSQLLSLL----VEFVYQLVCSGQLYL 1279
            ...||.:..|.:::.               .|.:.||...:...|:    .|...:|:.:.|:.
Human   141 DALAKNSPGLCLKICYFVRYWITEFWVMFKMDASLTDTMEEFQELVKAKGEELHCRLIDTTQIN- 204

  Fly  1280 AKLLRNKFVEKV--TLYKEPKVYGFVGELGGAGSVGGAGIAGSGGCSGTAGGGNQPSLL--DLKS 1340
            |:....|..:::  ...|:.||                                  |||  .|:.
Human   205 ARDWSRKLTQRIKSNTSKKRKV----------------------------------SLLFDHLEP 235

  Fly  1341 LEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKER 1405
            .|::|.:|.|:.:.|.:|...:...:..:.|.:::|.:.:.....|.:|.|.:..:|.....:.|
Human   236 EELSEHLTYLEFKSFRRISFSDYQNYLVNSCVKENPTMERSIALCNGISQWVQLMVLSRPTPQLR 300

  Fly  1406 EKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRL-EWQKGITEEVR----SFCALIDSSSS 1465
            .:...|||::.:.|.::.|:|:.:|::..|....|.|| |....:..|:.    ....|:.||.:
Human   301 AEVFIKFIQVAQKLHQLQNFNTLMAVIGGLCHSSISRLKETSSHVPHEINKVLGEMTELLSSSRN 365

  Fly  1466 FRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKCAY 1530
            :..||:|..|.....||.:|:.|:||..::....|||..|.:|..|....||.|..:.:.::.|.
Human   366 YDNYRRAYGECTDFKIPILGVHLKDLISLYEAMPDYLEDGKVNVHKLLALYNHISELVQLQEVAP 430

  Fly  1531 PFRRNERIIRFFDNFKD-FMGEEEMWQISEKIKPRGRR 1567
            |...|:.::.......| :..|:|::::|...:||..|
Human   431 PLEANKDLVHLLTLSLDLYYTEDEIYELSYAREPRNHR 468

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	32/163 (20%)
		RasGEF	1335..1558	CDD:238087	57/230 (25%)
RASGRP1	XP_047288029.1	RasGEFN	83..204	CDD:214571	27/132 (20%)
		RasGEF	230..466	CDD:214539	57/235 (24%)
		FRQ1	<500..556	CDD:444056
		C1_RASGRP1	569..623	CDD:410410
		cc_RasGRP1_C	768..822	CDD:412086