DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C3G and ralgps1

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	XP_031746936.1	Gene:	ralgps1 / 100495235	XenbaseID:	XB-GENE-996181	Length:	622	Species:	Xenopus tropicalis

Alignment Length:	317	Identity:	85/317 - (26%)
Similarity:	150/317 - (47%)	Gaps:	46/317 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly  1289 EKVTLYKEPKV-YGFVGELGG-AGSVGGAGIAGSGGCSGTAGGGNQP------------SLLDLK 1339
            :::.|.|.|.: :|.:.:..| ..||........|..|..:..|...            .:|.:.
Frog     7 QQLRLAKSPSIPWGSMYKRNGLMASVTVTAATPEGSSSSDSMDGQSSDYANKSYDAVVFDVLKVT 71

  Fly  1340 SLEIAEQMTLLDAELFTKIEIPEVLLFAKDQCEEK---SPNLNKFTEHFNKMSYWARSKILRLQD 1401
            ..|.|.|:||:|..:|.:| :||.|.......:||   :||:..||..||::|:|...:||..|.
Frog    72 PEEFASQITLMDVPVFKEI-LPEELASCGWNKKEKHILAPNVVAFTRRFNQVSFWVVREILTAQT 135

  Fly  1402 AKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRL--EW------QKGITEEVRSFCA 1458
            .|.|.:.::.|:||.|.|.::||.:|.:|::|||.|.||.||  .|      .|...|::....:
Frog   136 LKIRAEILSHFVKIAKKLLELNNIHSLMAVVSALQSAPIFRLTKTWALLNRKDKTTFEKLDYLLS 200

  Fly  1459 LIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMK 1523
            ..|:....|.:.::|...  |||||:||.|.|:.::   :..|.:.|.|  .:..|:.|.::|:.
Frog   201 KEDNCKRMREHIRSLKMV--PCIPYLGLYLLDIIYI---DSAYPASGSI--MENEQRTNQMNNIL 258

  Fly  1524 RF-----KKCAYP-------FRRNERIIRFFDNFKDFMGEEEMWQISEKIKPRGRRP 1568
            |.     ..|.|.       .::..:.:|:.:..:.|: |::.:::|.:|:|....|
Frog   259 RIIADLQVSCIYDHLVTLPHVQKYLKSVRYIEELQKFV-EDDNYKLSLRIEPGNSSP 314

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	4/17 (24%)
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	71/245 (29%)
ralgps1	XP_031746936.1	RasGEF	67..311	CDD:214539	74/252 (29%)
ralgps1	XP_031746936.1	PH_RalGPS1_2	499..613	CDD:270120
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000