Protein Alignment C3G and rasgrf2

DIOPT Version :10

• Sequence 1: NP_572350.2
• Gene: C3G / 31618
• FlyBaseID: FBgn0259228
• Length: 1571
• Species: Drosophila melanogaster
• Sequence 2: XP_002942408.2
• Gene: rasgrf2 / 100486502
• XenbaseID: XB-GENE-483993
• Length: 1232
• Species: Xenopus tropicalis
• Alignment Length: 621
• Identity: 145/621 - (23%)
• Similarity: 259/621 - (41%)
• Gaps: 126/621 - (20%)

  Fly   991 ALPPKNYKQRKATSMVASPTLQPVI---VTTPPPSPKPTLGENGSTGRPDSRMATVCEELNDAVA 1052
            ::|.::.:...|||...|....|.:   .::|||.   :|....|..|  :|..::...||..:.
 Frog   688 SIPVRSLELFFATSQNLSDGKSPHLCRKFSSPPPL---SLSRTSSPIR--ARKLSLNSPLNSRIG 747

  Fly  1053 SEDAMPEPRSPVLDSNENVSAVDDGQTFYCHSHQLPAAEMEMSEDASSADNQPITTPQVLEEQEE 1117
            :           ||.:.:.||......|                  |.|.:.|.||.:|
 Frog   748 A-----------LDLSTSSSASSPTSVF------------------SPATSPPPTTAKV------ 777

  Fly  1118 PTAESRPLVAVHESVKPANVDEDEEAERADMLINMLEEVNITRYLILKKREEDGPEVKGGYIDAL 1182
            |...|:.|.:..:|  |.::||:.|..|.| |.|.|.. :|.|..:|:...          :|..
 Frog   778 PLDLSKGLSSPEQS--PGSIDENSENPRID-LCNKLRR-SIRRAAVLESVS----------LDRT 828

  Fly  1183 IVHASRVQKVADNAFCEAFITTFRTFIQPIDVIEKLTHRYTYFFCQVQDNKQKAA---KETFAL- 1243
            |..:|:....|:|:.|.:..|......:|..|             |..||::..:   ...||:
 Frog   829 IPESSQSTDTAENSPCRSPSTPRHLRYRPTGV-------------QASDNQRGCSVSPASAFAIA 880

  Fly  1244 --------------LVRVVND--LTSTDLTSQLLSLLVEFV------YQLVCSGQLYLAKLLRNK 1286
                          :.|:.:.  :.....|:::|::|..:|      ::|....::.:..||.:.
 Frog   881 TAGAGHGSPPGFNNMERICDKEFIIRRAATNRVLNVLRHWVSKHAQDFELNHEIKMNVVNLLEDV 945

  Fly  1287 FVEKVTLYKEPKVYGFVGELGGAGSVGGAGIAGSGGC----SGTAGGGNQPS---LLDLKSLEIA 1344
            ..:...|.:|.|        .....:..........|    .........||   |..|.::|:|
 Frog   946 LRDPDLLPQERK--------AATNILSALSQEEQDDCHLVLEDIINMSESPSSECLETLSAMELA 1002

  Fly  1345 EQMTLLDAELFTKIEIPEVL--LFAKDQCEEKSPNLNKFTEHFNKMSYWARSKILRLQDAKEREK 1407
            ||:||||..:|..|...|.|  .:.|....|::|.:.|.::|||.||....|:|::..|...|..
 Frog  1003 EQITLLDHIVFRSIPYQEFLGQGWMKPDKSERTPYIMKTSQHFNDMSNLVASEIMKHPDVPSRAS 1067

  Fly  1408 HVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE--WQKGITEEVRSFCALID-------SS 1463
            .:.|::.:....|.|:|||..|.:.|||:...:.||:  |.| ::::.:   ||:|       |.
 Frog  1068 SIEKWVVVADICRCMHNYNGVLEITSALNRSAVYRLKKTWAK-VSKQTK---ALMDKLQKTVSSE 1128

  Fly  1464 SSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDYLSKGVINFSKRWQQYNIIDNMKRFKKC 1528
            ..|:..|:.|...|||.:||:|:.|.||.|:..|..::..:|::||||.....:||..:::|::.
 Frog  1129 GRFKNLRETLKNCNPPSVPYLGMYLTDLAFIEEGTPNFTEEGLVNFSKMRMISHIIREIRQFQQT 1193

  Fly  1529 AYPFRRNERIIRFFDNFKDFMGEEEMWQISEKIKPR 1564
            .|......::.:|..|....:.|:.::::|.:|:||
 Frog  1194 PYRIEHQPKVTQFLLNKSRILDEDNLYELSLRIEPR 1229

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571	25/161 (16%)
		RasGEF	1335..1558	CDD:238087	71/233 (30%)
rasgrf2	XP_002942408.2	PH_RasGRF1_2	19..154	CDD:270081
		RhoGEF	243..424	CDD:214619
		PH	488..584	CDD:459697
		RasGEF_N	634..>682	CDD:459873
		REM	<896..967	CDD:470601	11/78 (14%)
		RasGEF	993..1229	CDD:214539	73/239 (31%)