DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment C3G and ralgps1

DIOPT Version :9

Sequence 1:	NP_572350.2	Gene:	C3G / 31618	FlyBaseID:	FBgn0259228	Length:	1571	Species:	Drosophila melanogaster
Sequence 2:	NP_001093616.1	Gene:	ralgps1 / 100101642	ZFINID:	ZDB-GENE-070720-16	Length:	581	Species:	Danio rerio

Alignment Length:	257	Identity:	79/257 - (30%)
Similarity:	132/257 - (51%)	Gaps:	32/257 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly  1335 LLDLKSLEIAEQMTLLDAELFTKIEIPEVLL---FAKDQCEEKSPNLNKFTEHFNKMSYWARSKI 1396
            :|.:...|.|.|:||:||.:|..|: ||.|.   :.|.:....|||:..||..||::|:||..:|
Zfish    45 MLKVTPEEFASQITLMDAPVFKAIQ-PEELASCGWNKKEKHSLSPNVVAFTRRFNQVSFWAVREI 108

  Fly  1397 LRLQDAKEREKHVNKFIKIMKHLRKMNNYNSYLALLSALDSGPIRRLE--W------QKGITEEV 1453
            |..|..|.|.:.:..||||.|.|.::||.:|.::::|||.|.||.||.  |      .|...|::
Zfish   109 LTAQTLKIRAEILGHFIKIAKKLLELNNLHSLVSVVSALQSAPIFRLSKTWALISRKDKATFEKL 173

  Fly  1454 RSFCALIDSSSSFRAYRQALAETNPPCIPYIGLILQDLTFVHVGNQDY-LSKGVINFSKRWQQYN 1517
            ....:..::.:..|.|.::|...  |||||:|:.|.|:|::   :..| .|..:|...:|..|.|
Zfish   174 DFLTSKEENYNRMREYTRSLKMA--PCIPYLGIYLFDMTYI---DSAYPASDSIIETEQRTNQMN 233

  Fly  1518 ----IIDNMKRFKKCAYP-------FRRNERIIRFFDNFKDFMGEEEMWQISEKIKPRGRRP 1568
                ||.:::  ..|.|.       .::....:|:.:..:.|: |::.:.:|.||:|....|
Zfish   234 NLLRIISDLQ--VSCKYDHLITLPHVQKYLMSVRYIEELQKFV-EDDNYSLSLKIEPGNSSP 292

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
C3G	NP_572350.2	RasGEFN	1170..1306	CDD:214571
C3G	NP_572350.2	RasGEF	1335..1558	CDD:238087	74/245 (30%)
ralgps1	NP_001093616.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..31
		RasGEF	46..289	CDD:214539	78/251 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	320..339
		PXXP	329..332
		PH	456..567	CDD:278594
		PH_RalGPS1_2	457..572	CDD:270120
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3417
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810