DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shf and tnr

DIOPT Version :9

Sequence 1:	NP_001284963.1	Gene:	shf / 31617	FlyBaseID:	FBgn0003390	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_919364.1	Gene:	tnr / 369191	ZFINID:	ZDB-GENE-030804-1	Length:	1350	Species:	Danio rerio

Alignment Length:	243	Identity:	58/243 - (23%)
Similarity:	89/243 - (36%)	Gaps:	64/243 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   208 SGRIPQEQKNFSIF-LPCTGNSSGTASFNVGLKIQTRHNKPLSGTPIRLNFKKECAHRGVYDIDA 271
            :.||...::..|:. ..|:.:..|.:|              :.|   ||:|..:|.| |.:.::.
Zfish   134 ASRIEMLEREVSLLRTQCSSSCCGESS--------------VMG---RLDFVPQCGH-GTFSMEV 180

  Fly   272 SNPTSLTTLQAPDPECSLKCGKNGYCNEHHICKCNVGYTGQYCETAFCFPQCLNGGNCTAPSVCT 336
                               ||          |.|..|:.|:.|....|...|...|.|.... |.
Zfish   181 -------------------CG----------CVCEEGWIGKNCTEPRCPDDCSGQGICIEGD-CV 215

  Fly   337 CPEGYQGTQCEGGICKDKCLNGGKCIQKDKCQCSKGYYGLRCEYSKCVIPCKNEGRCIGNNLCRC 401
            |...:.|..|....|...|.:.|.||. .:|.|.:.:.|..|...:|:..|.::|.|: |..|:|
Zfish   216 CDRNFGGENCSEPRCPSDCSDRGLCID-GECVCEEAFAGEDCSLGRCLNDCSDQGACV-NGSCQC 278

  Fly   402 PNGLRGDHCEI-----GRKQRSICKCRNGTCVSHKHCKCHPGFYGRHC 444
            .:|..|:.|.:     ...||.:||  .|.||      |..|:.|..|
Zfish   279 RSGFLGEDCSLIFCANNCSQRGVCK--EGFCV------CQEGYTGDDC 318

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shf	NP_001284963.1	WIF	137..258	CDD:280237	9/50 (18%)
tnr	NP_919364.1	EGF_2	199..225	CDD:285248	7/26 (27%)
		EB	234..283	CDD:279949	16/50 (32%)
		EGF_2	294..318	CDD:285248	10/31 (32%)
		fn3	323..401	CDD:278470
		fn3	411..490	CDD:278470
		fn3	500..579	CDD:278470
		FN3	590..674	CDD:238020
		fn3	682..754	CDD:278470
		fn3	771..849	CDD:278470
		FN3	859..935	CDD:214495
		fn3	949..1019	CDD:278470
		fn3	1035..1103	CDD:278470
		FReD	1126..1336	CDD:238040
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810