DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shf and TNC

DIOPT Version :9

Sequence 1:	NP_001284963.1	Gene:	shf / 31617	FlyBaseID:	FBgn0003390	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	XP_016870167.1	Gene:	TNC / 3371	HGNCID:	5318	Length:	2384	Species:	Homo sapiens

Alignment Length:	419	Identity:	99/419 - (23%)
Similarity:	147/419 - (35%)	Gaps:	119/419 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   108 RHNRNEESGISLWINEQQLKMLTALYFPQGYSERLYAIHNSRVTNDLRDTTLYNFLVIPSE---- 168
            ||.|  :||::..:.|:...::    |...|:.:|..  .|:.:.||...:....|..|||
Human    30 RHKR--QSGVNATLPEENQPVV----FNHVYNIKLPV--GSQCSVDLESASGEKDLAPPSEPSES 86

  Fly   169 --------VNYVNFTWKSGRRKYFYDFDRLQTMDESILKAPTLSIRKSGRIPQEQKNF--SIFLP 223
                    .|.:.||            .|:.....:...|....:::.....:|.:|.  |:...
Human    87 FQEHTVDGENQIVFT------------HRINIPRRACGCAAAPDVKELLSRLEELENLVSSLREQ 139

  Fly   224 CTGNSSGTASFNVGLKIQTRHNKPLSGTPIRLNFKKECAHRGVYDIDASNPTSLTTLQAP---DP 285
            ||..:        |..:|     |.:|   ||:.:..|:.||.:..:..........:.|   :|
Human   140 CTAGA--------GCCLQ-----PATG---RLDTRPFCSGRGNFSTEGCGCVCEPGWKGPNCSEP 188

  Fly   286 ECSLKCGKNGYCNEHHICKCNVGYTGQYCETAFCFPQCLNGGNCTAPSVCTCPEGYQGTQC---- 346
            ||...|...|.|.:.. |.|:.|:||:.|....|...|.:.|.| ...||.|.|||.|..|
Human   189 ECPGNCHLRGRCIDGQ-CICDDGFTGEDCSQLACPSDCNDQGKC-VNGVCICFEGYAGADCSREI 251

  Fly   347 -------EGGICKD---------------------KCLNGGKCIQKDKCQCSKGYYGLRCEYSKC 383
                   |.|.|.|                     .|.|.|:|:: ::|.|.:|:.|..|....|
Human   252 CPVPCSEEHGTCVDGLCVCHDGFAGDDCNKPLCLNNCYNRGRCVE-NECVCDEGFTGEDCSELIC 315

  Fly   384 VIPCKNEGRCIGNNLCRCPNGLRGDHC----------EIGRKQRSICKC---------------- 422
            ...|.:.|||| |..|.|..|..|:.|          ..||.:...|.|
Human   316 PNDCFDRGRCI-NGTCYCEEGFTGEDCGKPTCPHACHTQGRCEEGQCVCDEGFAGVDCSEKRCPA 379

  Fly   423 ---RNGTCVSHKHCKCHPGFYGRHCNGRK 448
               ..|.||..: |:|..||.|..|...|
Human   380 DCHNRGRCVDGR-CECDDGFTGADCGELK 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shf	NP_001284963.1	WIF	137..258	CDD:280237	25/134 (19%)
TNC	XP_016870167.1	EGF_2	377..403	CDD:285248	8/26 (31%)
		EGF_2	408..434	CDD:285248	99/419 (24%)
		EGF_2	468..496	CDD:285248
		EGF_2	504..527	CDD:285248
		EGF_2	533..558	CDD:285248
		fn3	624..695	CDD:306538
		fn3	713..793	CDD:306538
		fn3	804..884	CDD:306538
		fn3	894..976	CDD:306538
		fn3	986..1064	CDD:306538
		fn3	1075..1154	CDD:306538
		fn3	1169..1241	CDD:306538
		fn3	1260..1327	CDD:306538
		fn3	1348..1427	CDD:306538
		fn3	1439..1508	CDD:306538
		fn3	1533..1605	CDD:306538
		fn3	1619..1691	CDD:306538
		fn3	1716..1788	CDD:306538
		fn3	1804..1883	CDD:306538
		fn3	1894..1973	CDD:306538
		fn3	1985..2055	CDD:306538
		fn3	2071..2143	CDD:306538
		Fibrinogen_C	2163..2372	CDD:278572
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810