DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shf and Itgb6

DIOPT Version :9

Sequence 1:	NP_001284963.1	Gene:	shf / 31617	FlyBaseID:	FBgn0003390	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001004263.1	Gene:	Itgb6 / 311061	RGDID:	1303119	Length:	787	Species:	Rattus norvegicus

Alignment Length:	401	Identity:	88/401 - (21%)
Similarity:	129/401 - (32%)	Gaps:	137/401 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 NRNEESGISLWINEQQLKMLTALYFPQGYSERLYAIHNSRVTNDLRDTTLYNFLVIPSEVN-YVN 173
            ||||.|            |.|.|.:|     .:..:.:..|.|::    |..|.|...:|: |.|
  Rat   297 NRNEYS------------MSTVLEYP-----TIGQLIDKLVQNNV----LLIFAVTQEQVHLYEN 340

  Fly   174 FTWKSGRRKYFYDFDRLQTMDESILKAPTLSI--RKSGRIPQ------EQKNFSIFLPCTGNSSG 230
            :.                    .::...|:.:  :.||.|.|      |:....:.|...|::.|
  Rat   341 YA--------------------KLIPGATVGLLQKDSGNILQLIISAYEELRSEVELEVLGDTEG 385

  Fly   231 ----------------------------TASFNVGLKIQT--RHNKPLSGTPIRLNFKKECAHRG 265
                                        ||||||.:.|..  :.::.|...|:.|....|.....
  Rat   386 LNLSFTALCSNGILFPHQKKCSHMKVGDTASFNVSVSITNCEKRSRKLIIKPVGLGDTLEILVSA 450

  Fly   266 VYDIDASNPTSLTTLQAPDPECSLKCGKNGYCNEHHICKCNVGYTGQYCE-------TAFC---- 319
            ..|.|........:.:......|.:||         :|.||.|:.|..||       |..|
  Rat   451 ECDCDCQREVEANSSKCHHGNGSFQCG---------VCACNPGHMGPRCECGEDMVSTDSCKESP 506

  Fly   320 -FPQCLNGGNCTAPSVCTCPEGYQGT------QCEGGIC-KDK---CLNGGKCIQKDKCQCSKGY 373
             .|.|...|:|.. ..|.|.....|:      ||:...| :.|   |.:.|.| ...:|.|..|:
  Rat   507 GHPSCSGRGDCYC-GQCVCHLSPYGSIYGPYCQCDNFSCLRHKGLLCGDNGDC-DCGECVCRDGW 569

  Fly   374 YGLRCEYSKCV-----------IPCKNEGRCI-GNNLCRCPNGLRGDHCEIGRKQRSICKCRNGT 426
            .|   ||..|.           :.|...|.|: |..:||.| |..|..||       .|......
  Rat   570 TG---EYCNCTTSRDACASEDGVLCSGRGDCVCGKCVCRNP-GASGPTCE-------RCPTCGDP 623

  Fly   427 CVSHKHC-KCH 436
            |.|.:.| :|:
  Rat   624 CNSRRSCIECY 634

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shf	NP_001284963.1	WIF	137..258	CDD:280237	27/159 (17%)
Itgb6	NP_001004263.1	Integrin_beta	30..454	CDD:278776	37/197 (19%)
		Cysteine-rich tandem repeats	456..619		45/184 (24%)
		Integrin_B_tail	624..705	CDD:285239	4/11 (36%)
		Interaction with HAX1. /evidence=ECO:0000250	730..757
		Integrin_b_cyt	732..774	CDD:285884
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000