DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shf and Tnn

DIOPT Version :9

Sequence 1:	NP_001284963.1	Gene:	shf / 31617	FlyBaseID:	FBgn0003390	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_001100659.2	Gene:	Tnn / 304913	RGDID:	1306002	Length:	1562	Species:	Rattus norvegicus

Alignment Length:	234	Identity:	54/234 - (23%)
Similarity:	81/234 - (34%)	Gaps:	55/234 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   261 CAHRG-------VYDIDA---------SNPTSLT------------------------TLQAPDP 285
            |:|:.       .|.||.         ::|.||:                        .||.|..
  Rat    33 CSHKDQQVTVSHTYKIDVPKSALVQVETDPQSLSDDGTSLLVPGEDGEEQNIIFRHNIRLQTPQK 97

  Fly   286 ECSLKCGKNGYCNEHHICKCNVGYTGQYCETAFCFP-------QCLNGGNCTAPSV-CTCPEGYQ 342
            .|.|..............:..:....:.|.|:.|..       .|...|...|.:. |.|.:|::
  Rat    98 NCELADSVQDLLARVKKLEEEMAELKEQCSTSRCCQGAADLSRHCSGHGTFFAETCSCHCDQGWE 162

  Fly   343 GTQCEGGICKDKCLNGGKCIQKDKCQCSKGYYGLRCEYSKCVIPCKNEGRCIGNNLCRCPNGLRG 407
            |..||...|...|...|:|:. .:|.|.:.|.|:.|.|:.|...|...|.|: ..:|:|......
  Rat   163 GADCEQPTCPGACSGHGRCVD-GQCVCDQPYVGVDCAYAACPQDCSGHGVCV-RGVCQCHKDFTA 225

  Fly   408 DHCEIGRKQRSICKCR-NGTCVSHKHCKCHPGFYGRHCN 445
            :.|.   :||....|. ||.|.:.: |.|..||.|..|:
  Rat   226 EDCS---EQRCPGDCSGNGFCDTGE-CYCEMGFTGPDCS 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shf	NP_001284963.1	WIF	137..258	CDD:280237
Tnn	NP_001100659.2	EGF_2	<142..166	CDD:285248	7/23 (30%)
		EGF_2	169..197	CDD:285248	8/28 (29%)
		EB	181..233	CDD:279949	15/56 (27%)
		EGF_2	233..259	CDD:285248	9/26 (35%)
		fn3	264..332	CDD:278470
		fn3	359..434	CDD:278470
		fn3	444..521	CDD:278470
		FN3	532..608	CDD:214495
		FN3	620..696	CDD:214495
		fn3	708..785	CDD:278470
		fn3	796..875	CDD:278470
		fn3	884..961	CDD:278470
		fn3	972..1049	CDD:278470
		FN3	1060..1136	CDD:214495
		FN3	1148..1224	CDD:214495
		fn3	1236..1313	CDD:278470
		FReD	1327..1540	CDD:238040
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900