DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment shf and Wif1

DIOPT Version :9

Sequence 1:	NP_001284963.1	Gene:	shf / 31617	FlyBaseID:	FBgn0003390	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_036045.1	Gene:	Wif1 / 24117	MGIID:	1344332	Length:	379	Species:	Mus musculus

Alignment Length:	341	Identity:	115/341 - (33%)
Similarity:	170/341 - (49%)	Gaps:	40/341 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   114 ESGISLWINEQQLKMLTALYFPQGYSERLYAIHNSRV---TNDLRDTTLYNFLVIPSEVNYVNFT 175
            |..:.|||:..|.::|.      |:.|.:..:...::   |:|.|... .....||..::.:|||
Mouse    33 EESLYLWIDAHQARVLI------GFEEDILIVSEGKMAPFTHDFRKAQ-QRMPAIPVNIHSMNFT 90

  Fly   176 WK-SGRRKYFYDFDRLQTMDESILKAPTLSIRKSGRIPQEQKNFSIFLPCTGNSSGTASFNVGLK 239
            |: :|:.:|||:|..|:::|:.|:..||:::...|.:|.:.....:..||.|...|.|:|.|.:.
Mouse    91 WQAAGQAEYFYEFLSLRSLDKGIMADPTVNVPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVNVI 155

  Fly   240 IQTRHNKPLSGTPIRLNFKKECAHRGVYDIDASNPTSLTTLQAPDPECSLKCGKNGYCNEHHICK 304
            :.......:..||....|.|.|.                  ||   ||...|...|:|||..:|:
Mouse   156 VMNSEGNTILRTPQNAIFFKTCQ------------------QA---ECPGGCRNGGFCNERRVCE 199

  Fly   305 CNVGYTGQYCETAFCFPQCLNGGNCTAPSVCTCPEGYQGTQCEGGICKDKCLNGGKCIQKDKCQC 369
            |..|:.|.:||.|.|.|:|:|||.|..|..|.||.|:.|..|:...|...|.|||.|....||.|
Mouse   200 CPDGFYGPHCEKALCIPRCMNGGLCVTPGFCICPPGFYGVNCDKANCSTTCFNGGTCFYPGKCIC 264

  Fly   370 SKGYYGLRCEYSKCVIPCKNEGRCIGNNLCRCPNGLRGDHCEIGRKQRSICK--C-RNGTCVSHK 431
            ..|..|.:||.|||..||:|.|:|||.:.|:||.|.:||.|     .:.:|:  | .:|||....
Mouse   265 PPGLEGEQCELSKCPQPCRNGGKCIGKSKCKCPKGYQGDLC-----SKPVCEPGCGAHGTCHEPN 324

  Fly   432 HCKCHPGFYGRHCNGR 447
            .|:|..|::|||||.|
Mouse   325 KCQCREGWHGRHCNKR 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shf	NP_001284963.1	WIF	137..258	CDD:280237	32/124 (26%)
Wif1	NP_036045.1	WIF	35..179	CDD:128745	40/168 (24%)
Wif1	NP_036045.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	348..379
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9733
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31430
Inparanoid	1	1.050	232	1.000	Inparanoid score	I3422
Isobase	1	0.950	-	0	Normalized mean entropy	S5912
OMA	1	1.010	-	-		QHG47613
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0007895
OrthoInspector	1	1.000	-	-		oto94704
orthoMCL	1	0.900	-	-		OOG6_109902
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4825
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.750