DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment shf and WIF1

DIOPT Version :9

Sequence 1:	NP_001284963.1	Gene:	shf / 31617	FlyBaseID:	FBgn0003390	Length:	460	Species:	Drosophila melanogaster
Sequence 2:	NP_009122.2	Gene:	WIF1 / 11197	HGNCID:	18081	Length:	379	Species:	Homo sapiens

Alignment Length:	342	Identity:	115/342 - (33%)
Similarity:	170/342 - (49%)	Gaps:	40/342 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 EESGISLWINEQQLKMLTALYFPQGYSERLYAIHNSRV---TNDLRDTTLYNFLVIPSEVNYVNF 174
            :|..:.|||:..|.::|.      |:.|.:..:...::   |:|.|... .....||..::.:||
Human    32 QEESLYLWIDAHQARVLI------GFEEDILIVSEGKMAPFTHDFRKAQ-QRMPAIPVNIHSMNF 89

  Fly   175 TWK-SGRRKYFYDFDRLQTMDESILKAPTLSIRKSGRIPQEQKNFSIFLPCTGNSSGTASFNVGL 238
            ||: :|:.:|||:|..|:::|:.|:..||:::...|.:|.:.....:..||.|...|.|:|.|.:
Human    90 TWQAAGQAEYFYEFLSLRSLDKGIMADPTVNVPLLGTVPHKASVVQVGFPCLGKQDGVAAFEVDV 154

  Fly   239 KIQTRHNKPLSGTPIRLNFKKECAHRGVYDIDASNPTSLTTLQAPDPECSLKCGKNGYCNEHHIC 303
            .:.......:..||....|.|.|.                  ||   ||...|...|:|||..||
Human   155 IVMNSEGNTILQTPQNAIFFKTCQ------------------QA---ECPGGCRNGGFCNERRIC 198

  Fly   304 KCNVGYTGQYCETAFCFPQCLNGGNCTAPSVCTCPEGYQGTQCEGGICKDKCLNGGKCIQKDKCQ 368
            :|..|:.|.:||.|.|.|:|:|||.|..|..|.||.|:.|..|:...|...|.|||.|....||.
Human   199 ECPDGFHGPHCEKALCTPRCMNGGLCVTPGFCICPPGFYGVNCDKANCSTTCFNGGTCFYPGKCI 263

  Fly   369 CSKGYYGLRCEYSKCVIPCKNEGRCIGNNLCRCPNGLRGDHCEIGRKQRSICK--C-RNGTCVSH 430
            |..|..|.:||.|||..||:|.|:|||.:.|:|..|.:||.|     .:.:|:  | .:|||...
Human   264 CPPGLEGEQCEISKCPQPCRNGGKCIGKSKCKCSKGYQGDLC-----SKPVCEPGCGAHGTCHEP 323

  Fly   431 KHCKCHPGFYGRHCNGR 447
            ..|:|..|::|||||.|
Human   324 NKCQCQEGWHGRHCNKR 340

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
shf	NP_001284963.1	WIF	137..258	CDD:280237	32/124 (26%)
WIF1	NP_009122.2	WIF	35..179	CDD:128745	40/168 (24%)
WIF1	NP_009122.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	354..379
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	68	1.000	Domainoid score	I9740
eggNOG	1	0.900	-	-		E1_KOG1225
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H31430
Inparanoid	1	1.050	229	1.000	Inparanoid score	I3459
Isobase	1	0.950	-	0	Normalized mean entropy	S5912
OMA	1	1.010	-	-		QHG47613
OrthoDB	1	1.010	-	-		D1016037at2759
OrthoFinder	1	1.000	-	-		FOG0007895
OrthoInspector	1	1.000	-	-		oto91119
orthoMCL	1	0.900	-	-		OOG6_109902
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4825
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	14	13.760