DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG14439 and Spns3

DIOPT Version :9

Sequence 1:	NP_001188550.1	Gene:	CG14439 / 31614	FlyBaseID:	FBgn0029898	Length:	535	Species:	Drosophila melanogaster
Sequence 2:	NP_084208.1	Gene:	Spns3 / 77577	MGIID:	1924827	Length:	514	Species:	Mus musculus

Alignment Length:	462	Identity:	104/462 - (22%)
Similarity:	169/462 - (36%)	Gaps:	121/462 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 CYALDFNGTGYCEW-----------NYNGLGIDYQILAGPTFILIFTIAGVFMGFAADKYNRVNM 130
            ||   .|...|..|           .|..:...:..|....||....::....|:..|:|||..:
Mouse    56 CY---INLLNYMNWFIIPGVLLDVQKYFHISDSHAGLLQTVFISCLLVSAPVFGYLGDRYNRKAI 117

  Fly   131 LTVCTVIFGIAMI----LQGTVKEY---WQLVILRMIMAAGESGCNPLATGIMSDIFPEDKRALV 188
            |:     |||.:.    |..:...|   |...:.|..:..|.:..:.:|..::.|:|.:|:|...
Mouse   118 LS-----FGILLWSGAGLSSSFISYQYSWLFFLSRGFVGTGAASYSTIAPTVLGDLFVKDQRTCA 177

  Fly   189 MAIFNWGIYGGYGIAFPVGRYITKL--NF-WNLGWRVCYLGAGVLTVIMAALTGTTLREPE-RKA 249
            :|:|...|..|.|:.:.:|..:.:|  |: |.|....| |.|..|.:::       |..|: .:.
Mouse   178 LAVFYIFIPVGSGLGYVLGSTVAELTGNWRWALRLMPC-LDAMALALLI-------LLVPDVPRG 234

  Fly   250 IGEGDRQTSSGKPVSLWQVIKNPAMIMLMIAASIRHCG-GMTFAYNADLYYNTYFPDVDLGWW-- 311
            ..|...:.:...|.|.|             ...:|:.| ..:|.::........|....||:|
Mouse   235 AAEKQGEVAVRAPRSSW-------------CEDVRYLGRNWSFVFSTLGVTAIAFVTGALGFWAP 286

  Fly   312 ---------------------------LFG-VTIGIGSVGVVVGGIVSDKIVAKMGIRSRAFVLA 348
                                       :|| :|:..|.:||::|...|.: ..|:..|:...:.|
Mouse   287 KFLFEARVVHGLQLPCFQEQCHSQDSLIFGALTVATGIIGVMLGAEASRR-YKKVNPRAEPLICA 350

  Fly   349 VSQLIATLPAFGSVYFDPLWAMITLGLSYFF---AEMWFGIVFAIVVEIVPLRVRSSTIGVFLFV 410
             |.|.||.|.   :|...:.|..||..||.|   .|:.....:|:|.:|: |.|          |
Mouse   351 -SSLFATAPC---LYLALILASRTLLASYVFLALGELLLSCNWAVVADIL-LSV----------V 400

  Fly   411 MNNIGGNLPILVDPVAKILGYRGSIMIFYAGFYGISSILFFITCFLLEGKPDEVGQPESPKSHPD 475
            :....|....|...||.:||..||  .:..|.  |||:|                |.|.|.|:..
Mouse   401 VPRCRGTAEALQITVAHVLGDAGS--PYLTGL--ISSVL----------------QAERPDSYLQ 445

  Fly   476 AVLNARH 482
            ..|:.:|
Mouse   446 HFLSLQH 452

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG14439	NP_001188550.1	MFS_1	94..416	CDD:284993	79/366 (22%)
CG14439	NP_001188550.1	MFS	107..452	CDD:119392	91/389 (23%)
Spns3	NP_084208.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..22
		MFS	53..470	CDD:119392	104/462 (23%)
		MFS_1	55..418	CDD:284993	89/406 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..514
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1330
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810