DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3168 and SV2A

DIOPT Version :9

Sequence 1:	NP_001284957.1	Gene:	CG3168 / 31612	FlyBaseID:	FBgn0029896	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001315603.1	Gene:	SV2A / 9900	HGNCID:	20566	Length:	742	Species:	Homo sapiens

Alignment Length:	725	Identity:	186/725 - (25%)
Similarity:	307/725 - (42%)	Gaps:	143/725 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LQPNYNQSAASNQASNHPTGQANAPATGNATSHIDNRAIIQPYSLGTGPKQPEYQFAADN--RGY 82
            :|..|::.:.|............||:.|              |..|.|.:..|...|:.:  .|:
Human    37 VQDEYSRRSYSRFEEEDDDDDFPAPSDG--------------YYRGEGTQDEEEGGASSDATEGH 87

  Fly    83 EPDSHA-NGKQQDVERDAPDGGHG------------------GHGPPGKGGKGGKGRKKSVPLPE 128
            :.|... .|:.|.:.| |..||.|                  |.|||  ||:|...|:|.
Human    88 DEDDEIYEGEYQGIPR-AESGGKGERMADGAPLAGVRGGLSDGEGPP--GGRGEAQRRKE----- 144

  Fly   129 PTAPIVANFERAIELCGYGKFHYILLAICGLVSTSEEMDVISMSFILPSAECDLDLNTETKGWLN 193
             ...:...:|..:..||:|:|.:.|..:.||...::.::|..:.|:|||||.|:.|:...||.|.
Human   145 -REELAQQYEAILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLG 208

  Fly   194 SIIFIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCIVASSFSQTYSFFMLFRFLNGAALGGSG 258
            .|:::||||||:.||.:||..||::.|::...:|:.....|||.|.|..|:..|.|:|..:|||.
Human   209 LIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSI 273

  Fly   259 PVIWSYFAEFQPKAKRGSMLSFMAAFWTFGNLFVASLAWLIIPRTIGFTTPY---FTYNSWRIFL 320
            |:::|||:||..:.|||..||::..||..|.::.|::||.|||. .|::...   :.::|||:|:
Human   274 PIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPH-YGWSFQMGSAYQFHSWRVFV 337

  Fly   321 LVCSLPS-FLVGFLLFYLPESPKFLLTRGKKDRALAIFRGIFVTNTKRRPDEYMVYD------LE 378
            |||:.|| |.:|.|... ||||:|.|..||.|.|..:.:.:..||.:.:.....|:.      :.
Human   338 LVCAFPSVFAIGALTTQ-PESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIH 401

  Fly   379 VDEKLLESNGNVKNKYSR------MISGMV-DHSRALFKSPILRFTIVSITINFTFHIGYYGLLM 436
            .:::|:|...:....|.|      .:.|.| .:..:.|.....|.|::.:.:.||....||||.:
Human   402 QEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFGPEYRRITLMMMGVWFTMSFSYYGLTV 466

  Fly   437 WFPELFNRFEEYE-----KAFP-------------------------DQSAGV------------ 459
            |||::....:..:     |.||                         |:..|:
Human   467 WFPDMIRHLQAVDYASRTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLF 531

  Fly   460 --CAVTD------------------YVVNLAKEQ------------SNNGTCSSDIPQS------ 486
              |...|                  |..:|.:.:            .|...|..|:..:
Human   532 EECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLINSTFLHNKEGCPLDVTGTGEGAYM 596

  Fly   487 VFMESLISLASALPANLLAILGMDMLGRKFFLIAGTMTAGICSALMYFVRSSVQNLVVSAIFSGA 551
            |:..|.:...:.||.|:::.|.||.:||...|...::.:.:....:.|..|....:.:..:|.|.
Human   597 VYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVMSCVSCFFLSFGNSESAMIALLCLFGGV 661

  Fly   552 ISAANAALDCLITEVFPTKLRATGVAISMVAARLGGIIGNIVIAQLLDNYCPSPTFIVSGLLIGG 616
            ..|:..|||.|..|::|:..|.|.........:|..::|..:....:.....:|....|..|..|
Human   662 SIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALALG 726

  Fly   617 GLMCLLLPNT 626
            ..:.|.||.|
Human   727 SSLALKLPET 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3168	NP_001284957.1	2A0115	149..598	CDD:273327	145/545 (27%)
CG3168	NP_001284957.1	MFS	154..623	CDD:119392	148/565 (26%)
SV2A	NP_001315603.1	synapt_SV2	1..742	CDD:130366	186/725 (26%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	33..144		28/123 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	164	1.000	Domainoid score	I3941
eggNOG	1	0.900	-	-		E33208_3B9V0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	295	1.000	Inparanoid score	I2755
Isobase	1	0.950	-	0	Normalized mean entropy	S5294
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208328at33208
OrthoFinder	1	1.000	-	-		FOG0001322
OrthoInspector	1	1.000	-	-		mtm8480
orthoMCL	1	0.900	-	-		OOG6_102121
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X658
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.710