Protein Alignment CG3168 and SV2B

DIOPT Version :10

• Sequence 1: NP_572345.1
• Gene: CG3168 / 31612
• FlyBaseID: FBgn0029896
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_055663.1
• Gene: SV2B / 9899
• HGNCID: 16874
• Length: 683
• Species: Homo sapiens
• Alignment Length: 690
• Identity: 190/690 - (27%)
• Similarity: 305/690 - (44%)
• Gaps: 140/690 - (20%)

  Fly    72 EYQFAADNRGYEP-DSHANGKQQDVERDAPDGGHGGHGPPGKGGKGGKGRKKSVPLPEPT----- 130
            :|::..:..||.| |.:..|.:.:.|.||......||   .:..:..:|..:.:|.|:..
Human     3 DYKYQDNYGGYAPSDGYYRGNESNPEEDAQSDVTEGH---DEEDEIYEGEYQGIPHPDDVKAKQA 64

  Fly   131 --AP----------------------IVANFERAIELCGYGKFHYILLAICGLVSTSEEMDVISM 171
              ||                      :...:|..::.||:|:|.:||..:.||...::.::|..:
Human    65 KMAPSRMDSLRGQTDLMAERLEDEEQLAHQYETIMDECGHGRFQWILFFVLGLALMADGVEVFVV 129

  Fly   172 SFILPSAECDLDLNTETKGWLNSIIFIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCIVASSF 236
            ||.|||||.|:.|::..||.|..|:::|||.||:..|.:||..|||:||.:...:||.....|||
Human   130 SFALPSAEKDMCLSSSKKGMLGMIVYLGMMAGAFILGGLADKLGRKRVLSMSLAVNASFASLSSF 194

  Fly   237 SQTYSFFMLFRFLNGAALGGSGPVIWSYFAEFQPKAKRGSMLSFMAAFWTFGNLFVASLAWLIIP 301
            .|.|..|:..|.::|..:||:.|::::||:||..:.|||..||::..||..|.|:.:::||.|||
Human   195 VQGYGAFLFCRLISGIGIGGALPIVFAYFSEFLSREKRGEHLSWLGIFWMTGGLYASAMAWSIIP 259

  Fly   302 R-TIGFT--TPYFTYNSWRIFLLVCSLPSFLVGFLLFYLPESPKFLLTRGKKDRALAIFRGIFVT 363
            . ..||:  |.|. ::|||:|::||:||..:....|.::||||:|||..||.|.|..|.:.:..|
Human   260 HYGWGFSMGTNYH-FHSWRVFVIVCALPCTVSMVALKFMPESPRFLLEMGKHDEAWMILKQVHDT 323

  Fly   364 NTKRRPDEYMVYDL-------EVDEKLLESNGNVKNKYSRMISGMVDHSRALFK----------- 410
            |.:.:.....|:.:       ::|| .:|...:....|.|.:.    ..:.:||
Human   324 NMRAKGTPEKVFTVSNIKTPKQMDE-FIEIQSSTGTWYQRWLV----RFKTIFKQVWDNALYCVM 383

  Fly   411 SPILRFTIVSITINFTFHIGYYGLLMWFPELFNRF--EEYEK----------------------- 450
            .|....|::...:.|.....||||.:|||::...|  |||:.
Human   384 GPYRMNTLILAVVWFAMAFSYYGLTVWFPDMIRYFQDEEYKSKMKVFFGEHVYGATINFTMENQI 448

  Fly   451 -------------------AFPDQSAGVCAVTD------YVVNLAKEQS---------------- 474
                               .|.|.....|...|      |..|...|.:
Human   449 HQHGKLVNDKFTRMYFKHVLFEDTFFDECYFEDVTSTDTYFKNCTIESTIFYNTDLYEHKFINCR 513

  Fly   475 -NNGT-------CSSDIPQS----VFMESLISLASALPANLLAILGMDMLGRKFFLIAGTM-TAG 526
             .|.|       |..|:.|.    :::.|.:...|.||.|:::.|.||.:|| ..:|.|:| .:.
Human   514 FINSTFLEQKEGCHMDLEQDNDFLIYLVSFLGSLSVLPGNIISALLMDRIGR-LKMIGGSMLISA 577

  Fly   527 ICSALMYFVRSSVQNLVVSAIFSGAISAANAALDCLITEVFPTKLRATGVAISMVAARLGGIIGN 591
            :|...::|..|....:....:|.|...||..|||.:..|::||..|||...|.....:.|.|:||
Human   578 VCCFFLFFGNSESAMIGWQCLFCGTSIAAWNALDVITVELYPTNQRATAFGILNGLCKFGAILGN 642

  Fly   592 IVIAQLLDNYCPSPTFIVSGLLIGGGLMCLLLPNTTRKEL 631
            .:.|..:......|..:.:..|:||||:.|.||.|..:.|
Human   643 TIFASFVGITKVVPILLAAASLVGGGLIALRLPETREQVL 682

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3168	NP_572345.1	synapt_SV2	<137..626	CDD:130366	172/588 (29%)
SV2B	NP_055663.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..42		11/41 (27%)
		synapt_SV2	8..683	CDD:130366	189/685 (28%)