DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3168 and SLC22A6

DIOPT Version :9

Sequence 1:	NP_001284957.1	Gene:	CG3168 / 31612	FlyBaseID:	FBgn0029896	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_004781.2	Gene:	SLC22A6 / 9356	HGNCID:	10970	Length:	563	Species:	Homo sapiens

Alignment Length:	447	Identity:	106/447 - (23%)
Similarity:	187/447 - (41%)	Gaps:	82/447 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   194 SIIFIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCIVASSFSQTYSFFMLFRFLNGAALGGSG 258
            |:..:|:::||..:|.:||..||:||||:.....|.....::|:..:..:..||.|:|.||.|..
Human   139 SLYMVGVLLGAMVFGYLADRLGRRKVLILNYLQTAVSGTCAAFAPNFPIYCAFRLLSGMALAGIS 203

  Fly   259 PVIWSYFAEFQPKAKRGSMLSFMAAFWTFGNLFVASLAWLIIPRTIGFTTPYFTYNSWRIFLLVC 323
            ....:...|:.|...|..:.:.:...::.|...:|.:|:.:         |:     ||...|:.
Human   204 LNCMTLNVEWMPIHTRACVGTLIGYVYSLGQFLLAGVAYAV---------PH-----WRHLQLLV 254

  Fly   324 SLPSFLVGFLLFYLPESPKFLLTRGKKDRALAIFRGIFVTNTKRRPDEYMVYDLEVDEKLLESNG 388
            |.|.|......::..||.::..:.|:.|..|...:.:...|.||  :|.....:||....|:...
Human   255 SAPFFAFFIYSWFFIESARWHSSSGRLDLTLRALQRVARINGKR--EEGAKLSMEVLRASLQKEL 317

  Fly   389 NV-KNKYSRMISGMVDHSRALFKSPILRFTIVSIT-INFTFHIGYYGLLMWFPELFNRFEEYEKA 451
            .: |.:.|.|         .|.:.|.||...:.:: :.|.....||||:|   :|
Human   318 TMGKGQASAM---------ELLRCPTLRHLFLCLSMLWFATSFAYYGLVM---DL---------- 360

  Fly   452 FPDQSAGVCAVTDYVVNLAKEQSNNGTCSSDIPQSVFMESLISLASALPANLLAILGMDMLGRKF 516
               |..||                          |:::..:|..|..|||.|:..|.::.|||:.
Human   361 ---QGFGV--------------------------SIYLIQVIFGAVDLPAKLVGFLVINSLGRRP 396

  Fly   517 FLIAGTMTAGICSAL-------MYFVRSSVQNLVVSAIFSGAISAANAALDCLITEVFPTKLRAT 574
            ..:|..:.||||..|       ...||:|     ::.:..|.::|:...:.....|::||.:|.|
Human   397 AQMAALLLAGICILLNGVIPQDQSIVRTS-----LAVLGKGCLAASFNCIFLYTGELYPTMIRQT 456

  Fly   575 GVAISMVAARLGGIIGNIVIAQLLDNYCPSPTFIVSGLLIGGGLMCLLLPNTTRKEL 631
            |:.:....||:|.|:..:| :...:.|...|.||...:.:....:.:|||.|..:.|
Human   457 GMGMGSTMARVGSIVSPLV-SMTAELYPSMPLFIYGAVPVAASAVTVLLPETLGQPL 512

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3168	NP_001284957.1	2A0115	149..598	CDD:273327	97/412 (24%)
CG3168	NP_001284957.1	MFS	154..623	CDD:119392	101/437 (23%)
SLC22A6	NP_004781.2	2A0119	11..515	CDD:273328	106/447 (24%)
		MFS	135..505	CDD:119392	102/438 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	525..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.940