DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3168 and QDR2

DIOPT Version :9

Sequence 1:	NP_001284957.1	Gene:	CG3168 / 31612	FlyBaseID:	FBgn0029896	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_012145.1	Gene:	QDR2 / 854685	SGDID:	S000001383	Length:	542	Species:	Saccharomyces cerevisiae

Alignment Length:	592	Identity:	126/592 - (21%)
Similarity:	204/592 - (34%)	Gaps:	178/592 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   120 RKKSV-PLPEPTAPIVANFERAIELCGYGKFHYILLAIC---GLVSTSEEMDVISMSF--ILPSA 178
            |.:|| |.||.|||..:.|.|:        |..:|:|.|   |..||     :....:  :|...
Yeast    37 RTESVKPEPEITAPPHSRFSRS--------FKTVLIAQCAFTGFFST-----IAGAIYYPVLSVI 88

  Fly   179 ECDLDLNTETKGWLNSIIFIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCIVASSFSQTYSFF 243
            |...|::.|.......:.|:...:...|.|..|||.||:.|::|...:.....:..:.:|||:..
Yeast    89 ERKFDIDEELVNVTVVVYFVFQGLAPTFMGGFADSLGRRPVVLVAIVIYFGACIGLACAQTYAQI 153

  Fly   244 MLFRFLNGAALGGSGPVI---WSYFAEFQPKAKRGSMLSFMAAFWTFGNLFVASLAWLIIPRTIG 305
            ::.|.|..|   |..|||   .....:...:|:||..:.::|.|...|:.|.|.:.       .|
Yeast   154 IVLRCLQAA---GISPVIAINSGIMGDVTTRAERGGYVGYVAGFQVLGSAFGALIG-------AG 208

  Fly   306 FTTPYFTYNSWRI---FLLVCSLPSFLVGFLLFYLPE-----------SPKFLLTRGKKDRALAI 356
            .::.:    .||.   ||.:.|...||..||:  |||           :||..|.|..
Yeast   209 LSSRW----GWRAIFWFLAIGSGICFLASFLI--LPETKRNISGNGSVTPKSYLNRAP------- 260

  Fly   357 FRGIFVTNTKRR------PDEYMVYDLEVDEKLLESNGNVKNKYS----RMISGMVDHSRALFKS 411
               |.|..|.|:      || |...:|.....|| :...:...|.    .:::|:      .|..
Yeast   261 ---ILVLPTVRKSLHLDNPD-YETLELPTQLNLL-APFKILKAYEICILMLVAGL------QFAM 314

  Fly   412 PILRFTIVSITINFTFHIGYYGL-LMWFPELFNRFEEYEKAFPDQSAGVCAVTDYVV-------- 467
            .....|.:|..::..:|:....: |.:.|                 :|:|.:...|:
Yeast   315 YTTHLTALSTALSKQYHLTVAKVGLCYLP-----------------SGICTLCSIVIAGRYLNWN 362

  Fly   468 -----------------NLAKEQSNNGTCSSDI----PQSVFMESLISLASALPANLLAILGMDM 511
                             .|.:|..|:......|    |:..|......|..|....||:..|...
Yeast   363 YRRRLKYYQNWLGKKRSKLLEEHDNDLNLVQRIIENDPKYTFNIFKARLQPAFVTLLLSSSGFCA 427

  Fly   512 LGRKFFLIAGTMTAGICSALMYFVRSSVQNLVVSAIFSGAISAANAALDCLITEVFPTKL-RATG 575
            .| ....:...:.|.:|.:            ..:::||..|...:..   ||.::||||. .|||
Yeast   428 YG-WCITVKAPLAAVLCMS------------GFASLFSNCILTFSTT---LIVDLFPTKTSTATG 476

  Fly   576 --------------VAISMVAARL--GGIIGNIVIAQLLDNYCPSPTFIVSGLLIGGGLMCLLLP 624
                          .|:|.:..::  ||:.                ||:  |.|.....:.|.:.
Yeast   477 CLNLFRCILSAVFIAALSKMVEKMKFGGVF----------------TFL--GALTSSSSILLFIL 523

  Fly   625 NTTRKEL 631
            ....|||
Yeast   524 LRKGKEL 530

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3168	NP_001284957.1	2A0115	149..598	CDD:273327	107/527 (20%)
CG3168	NP_001284957.1	MFS	154..623	CDD:119392	110/547 (20%)
QDR2	NP_012145.1	MFS_Tpo1_MDR_like	64..530	CDD:340881	111/555 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910