Protein Alignment CG3168 and SLC22A3

DIOPT Version :10

• Sequence 1: NP_572345.1
• Gene: CG3168 / 31612
• FlyBaseID: FBgn0029896
• Length: 632
• Species: Drosophila melanogaster
• Sequence 2: NP_068812.1
• Gene: SLC22A3 / 6581
• HGNCID: 10967
• Length: 556
• Species: Homo sapiens
• Alignment Length: 603
• Identity: 148/603 - (24%)
• Similarity: 242/603 - (40%)
• Gaps: 164/603 - (27%)

  Fly    64 LGTGP-----KQPEYQFAADNRGYEPDSHANGKQQDVERDAPDGGHGGHGPPGKGGKGGKGRKKS 123
            |||.|     :.|.....|:..|:.|:...|       |.||  ...|..||.:.|:..:...::
Human    42 LGTQPDHYWCRGPSAAALAERCGWSPEEEWN-------RTAP--ASRGPEPPERRGRCQRYLLEA 97

  Fly   124 V--------------PL---PEPTAPIVANFERAIELC----GYGKFHYILLAICGLVSTSEEMD 167
            .              ||   |..:||:|.        |    .|.:.|..:::         |.|
Human    98 ANDSASATSALSCADPLAAFPNRSAPLVP--------CRGGWRYAQAHSTIVS---------EFD 145

  Fly   168 VISMSFILPSAECDLDLNTETKGWLNSIIFIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCI- 231
            ::.::..:      |||.       .:|:.:|.:.||:..|..||.:||    |||..::...:
Human   146 LVCVNAWM------LDLT-------QAILNLGFLTGAFTLGYAADRYGR----IVIYLLSCLGVG 193

  Fly   232 ---VASSFSQTYSFFMLFRFLNGAALGGSGPVIWSYFAEFQPKAKRGSMLSFMAAFWTFGNLFVA 293
               |..:|:..:..|::||||.|....|:....:....|.....:|..:...:..|:|.|.:.:.
Human   194 VTGVVVAFAPNFPVFVIFRFLQGVFGKGTWMTCYVIVTEIVGSKQRRIVGIVIQMFFTLGIIILP 258

  Fly   294 SLAWLIIPRTIGFTTPYFTYNSWRIFLLVCSLPSFLVGFLLFY--LPESPKFLLTRGKKDRALAI 356
            .:|             ||..| |:...|..:|||||  |||:|  :||||::|:||.|.|:||.|
Human   259 GIA-------------YFIPN-WQGIQLAITLPSFL--FLLYYWVVPESPRWLITRKKGDKALQI 307

  Fly   357 FRGIFVTNTKRRPDEY---MVYDLEVDEKLLESNGNVKNKYSRMISGMVDHSRALFKSPILR-FT 417
            .|.|...|.|.....|   .|.|.||      ||.:..:               |.::|.:| .|
Human   308 LRRIAKCNGKYLSSNYSEITVTDEEV------SNPSFLD---------------LVRTPQMRKCT 351

  Fly   418 IVSITINFTFHIGYYGLLMWFPELFNRFEEYEKAFPDQSAGVCAVTDYVVNLAKEQSNNGTCSSD 482
            ::.:...||..:.|.||:|                   ..|:
Human   352 LILMFAWFTSAVVYQGLVM-------------------RLGI----------------------- 374

  Fly   483 IPQSVFMESLISLASALPANLLAILGMDMLGRKFFLIAGTMTAGICSALMYFVRSSVQNL--VVS 545
            |..:::::..||....||..||.:|.::.|||:....|..:.||:...:..|:...:..|  .|:
Human   375 IGGNLYIDFFISGVVELPGALLILLTIERLGRRLPFAASNIVAGVACLVTAFLPEGIAWLRTTVA 439

  Fly   546 AIFSGAISAANAALDCLITEVFPTKLRATGVAISMVAARLGGIIGNIVIAQLLDNYCPSPTFIVS 610
            .:....|:.|...:..:.:|::||.||..||::.......||||...::.:|...:...| .|:.
Human   440 TLGRLGITMAFEIVYLVNSELYPTTLRNFGVSLCSGLCDFGGIIAPFLLFRLAAVWLELP-LIIF 503

  Fly   611 GLL--IGGGLMCLLLPNT 626
            |:|  |.|||: :|||.|
Human   504 GILASICGGLV-MLLPET 520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG3168	NP_572345.1	synapt_SV2	<137..626	CDD:130366	125/506 (25%)
SLC22A3	NP_068812.1	2A0119	12..528	CDD:273328	148/603 (25%)
		Proline-rich sequence. /evidence=ECO:0000305|PubMed:26979622	289..293		3/3 (100%)