DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3168 and Sv2a

DIOPT Version :9

Sequence 1:	NP_001284957.1	Gene:	CG3168 / 31612	FlyBaseID:	FBgn0029896	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_071313.1	Gene:	Sv2a / 64051	MGIID:	1927139	Length:	742	Species:	Mus musculus

Alignment Length:	726	Identity:	187/726 - (25%)
Similarity:	306/726 - (42%)	Gaps:	145/726 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 LQPNYNQSAASNQASNHPTGQANAPATGNATSHIDNRAIIQPYSLGTGPKQPEYQFAADN--RGY 82
            :|..|::.:.|............|||.|              |..|.|.:..|...|:.:  .|:
Mouse    37 VQDEYSRRSYSRFEEEDDDDDFPAPADG--------------YYRGEGAQDEEEGGASSDATEGH 87

  Fly    83 EPDSHA-NGKQQDVERDAPDGGHG------------------GHGPPGKGGKGGKGRKKSVPLPE 128
            :.|... .|:.|.:.| |..||.|                  |.|||  ||:|...|:|.
Mouse    88 DEDDEIYEGEYQGIPR-AESGGKGERMADGAPLAGVRGGLSDGEGPP--GGRGEAQRRKD----- 144

  Fly   129 PTAPIVANFERAIELCGYGKFHYILLAICGLVSTSEEMDVISMSFILPSAECDLDLNTETKGWLN 193
             ...:...:|..:..||:|:|.:.|..:.||...::.::|..:.|:|||||.|:.|:...||.|.
Mouse   145 -REELAQQYETILRECGHGRFQWTLYFVLGLALMADGVEVFVVGFVLPSAEKDMCLSDSNKGMLG 208

  Fly   194 SIIFIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCIVASSFSQTYSFFMLFRFLNGAALGGSG 258
            .|:::||||||:.||.:||..||::.|::...:|:.....|||.|.|..|:..|.|:|..:|||.
Mouse   209 LIVYLGMMVGAFLWGGLADRLGRRQCLLISLSVNSVFAFFSSFVQGYGTFLFCRLLSGVGIGGSI 273

  Fly   259 PVIWSYFAEFQPKAKRGSMLSFMAAFWTFGNLFVASLAWLIIPRTIGFTTPY---FTYNSWRIFL 320
            |:::|||:||..:.|||..||::..||..|.::.|::||.|||. .|::...   :.::|||:|:
Mouse   274 PIVFSYFSEFLAQEKRGEHLSWLCMFWMIGGVYAAAMAWAIIPH-YGWSFQMGSAYQFHSWRVFV 337

  Fly   321 LVCSLPS-FLVGFLLFYLPESPKFLLTRGKKDRALAIFRGIFVTNTKRRPDEYMVYD------LE 378
            |||:.|| |.:|.|... ||||:|.|..||.|.|..:.:.:..||.:.:.....|:.      :.
Mouse   338 LVCAFPSVFAIGALTTQ-PESPRFFLENGKHDEAWMVLKQVHDTNMRAKGHPERVFSVTHIKTIH 401

  Fly   379 VDEKLLESNGNVKNKYSR------MISGMV-DHSRALFKSPILRFTIVSITINFTFHIGYYGLLM 436
            .:::|:|...:....|.|      .:.|.| .:..:.|.....|.|::.:.:.||....||||.:
Mouse   402 QEDELIEIQSDTGTWYQRWGVRALSLGGQVWGNFLSCFSPEYRRITLMMMGVWFTMSFSYYGLTV 466

  Fly   437 WFPELFNRFEEYE-----KAFP-------------------------DQSAGV------------ 459
            |||::....:..:     |.||                         |:..|:
Mouse   467 WFPDMIRHLQAVDYAARTKVFPGERVEHVTFNFTLENQIHRGGQYFNDKFIGLRLKSVSFEDSLF 531

  Fly   460 -----------------CA----------------VTDYVVNLAKEQSNNGTCSSDIPQS----- 486
                             |.                |...:||.....:..| |..|:..:
Mouse   532 EECYFEDVTSSNTFFRNCTFINTVFYNTDLFEYKFVNSRLVNSTFLHNKEG-CPLDVTGTGEGAY 595

  Fly   487 -VFMESLISLASALPANLLAILGMDMLGRKFFLIAGTMTAGICSALMYFVRSSVQNLVVSAIFSG 550
             |:..|.:...:.||.|:::.|.||.:||...|...::.:.:....:.|..|....:.:..:|.|
Mouse   596 MVYFVSFLGTLAVLPGNIVSALLMDKIGRLRMLAGSSVLSCVSCFFLSFGNSESAMIALLCLFGG 660

  Fly   551 AISAANAALDCLITEVFPTKLRATGVAISMVAARLGGIIGNIVIAQLLDNYCPSPTFIVSGLLIG 615
            ...|:..|||.|..|::|:..|.|.........:|..::|..:....:.....:|....|..|..
Mouse   661 VSIASWNALDVLTVELYPSDKRTTAFGFLNALCKLAAVLGISIFTSFVGITKAAPILFASAALAL 725

  Fly   616 GGLMCLLLPNT 626
            |..:.|.||.|
Mouse   726 GSSLALKLPET 736

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3168	NP_001284957.1	2A0115	149..598	CDD:273327	145/546 (27%)
CG3168	NP_001284957.1	MFS	154..623	CDD:119392	148/566 (26%)
Sv2a	NP_071313.1	synapt_SV2	1..742	CDD:130366	187/726 (26%)
		Interaction with SYT1. /evidence=ECO:0000250	1..57		3/19 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	40..145		29/127 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3860
eggNOG	1	0.900	-	-		E33208_3B9V0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	296	1.000	Inparanoid score	I2717
Isobase	1	0.950	-	0	Normalized mean entropy	S5294
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001322
OrthoInspector	1	1.000	-	-		mtm8715
orthoMCL	1	0.900	-	-		OOG6_102121
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	1	1.000	-	-		X658
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	11	10.700