DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3168 and SVOP

DIOPT Version :9

Sequence 1:	NP_001284957.1	Gene:	CG3168 / 31612	FlyBaseID:	FBgn0029896	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_061181.1	Gene:	SVOP / 55530	HGNCID:	25417	Length:	548	Species:	Homo sapiens

Alignment Length:	499	Identity:	127/499 - (25%)
Similarity:	225/499 - (45%)	Gaps:	64/499 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   138 ERAIELCGYGKFHYILLAICGLVSTSEEMDVISMSFILPSAECDLDLNTETKGWLNSIIFIGMMV 202
            |.|:|..|:|||.:.|..:.||...::.|:::.:|.:.|...|:..|.:.....|.|::|:|||.
Human    71 EDAVEAIGFGKFQWKLSVLTGLAWMADAMEMMILSILAPQLHCEWRLPSWQVALLTSVVFVGMMS 135

  Fly   203 GAYFWGSIADSFGRKKVLIVISFMNAFCIVASSFSQTYSFFMLFRFLNGAALGGSGPVIWSYFAE 267
            .:..||:|:|.:|||..|.:......:..:.|:|:..||:.::.|.|.|..:||. |...:.:||
Human   136 SSTLWGNISDQYGRKTGLKISVLWTLYYGILSAFAPVYSWILVLRGLVGFGIGGV-PQSVTLYAE 199

  Fly   268 FQPKAKRGSMLSFMAAFWTFGNLFVASLAWLIIPRTIGFTTPYFTYNSWRIFLLVCSLPSFLVGF 332
            |.|...|...:..:..||..|.:|...||..::| ::|          ||..|::.::|..|...
Human   200 FLPMKARAKCILLIEVFWAIGTVFEVVLAVFVMP-SLG----------WRWLLILSAVPLLLFAV 253

  Fly   333 LLFYLPESPKFLLTRGKKDRALAIFRGIFVTNTKRRPDEYMVYDLEVDEKLLESNGNVKNKYSRM 397
            |.|:||||.::.:..|.:::|:|..:.|...|....|...::...:      |..|.:::.:
Human   254 LCFWLPESARYDVLSGNQEKAIATLKRIATENGAPMPLGKLIISRQ------EDRGKMRDLF--- 309

  Fly   398 ISGMVDHSRALFKSPILRFTIVSI-TINFTFHIGYYGLLMWFPELFNRFEEYEKAFPDQSAGVCA 461
                         :|..|:|.:.: .|.|:....||||::...|||            |:..||.
Human   310 -------------TPHFRWTTLLLWFIWFSNAFSYYGLVLLTTELF------------QAGDVCG 349

  Fly   462 VTDYVVNLAKEQSNNGTCS---SDIPQSVFMESLISLASALPANLLAILGMDMLGRKFFLIAGTM 523
            ::      :::::....||   ..:.:..:|:.|.:..|..|..|:.:..:|.||||..:....:
Human   350 IS------SRKKAVEAKCSLACEYLSEEDYMDLLWTTLSEFPGVLVTLWIIDRLGRKKTMALCFV 408

  Fly   524 TAGICSALMYF-VRSSVQNL---VVSAIFSGAISAANAALDCLITEVFPTKLRATGVAISMVAAR 584
            ....||.|::. |..:|..|   :..|..||...||..    ...||:||..||.|:......||
Human   409 IFSFCSLLLFICVGRNVLTLLLFIARAFISGGFQAAYV----YTPEVYPTATRALGLGTCSGMAR 469

  Fly   585 LGGIIGNIVIAQLLDNYCPSPTFIVSGLLIGGGLMCLLLPNTTR 628
            :|.:|...:...:|::.......:.||..:...|....||..|:
Human   470 VGALITPFIAQVMLESSVYLTLAVYSGCCLLAALASCFLPIETK 513

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3168	NP_001284957.1	2A0115	149..598	CDD:273327	114/456 (25%)
CG3168	NP_001284957.1	MFS	154..623	CDD:119392	116/476 (24%)
SVOP	NP_061181.1	MFS_SVOP	87..509	CDD:340999	116/477 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG59613
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24064
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	4.050