DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3168 and slc22a4

DIOPT Version :9

Sequence 1:	NP_001284957.1	Gene:	CG3168 / 31612	FlyBaseID:	FBgn0029896	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_957143.1	Gene:	slc22a4 / 393822	ZFINID:	ZDB-GENE-040426-1517	Length:	553	Species:	Danio rerio

Alignment Length:	460	Identity:	108/460 - (23%)
Similarity:	189/460 - (41%)	Gaps:	80/460 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   179 ECDLDLNTETKGWL-NSIIFIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCIVASSFSQTYSF 242
            |.||....|.||.| :||.|.|::||.:..|.::|.:||:.||..:..:....|:...||.::..
Zfish   131 EWDLVCEREYKGPLTSSIYFCGVLVGTFLSGQMSDRYGRRPVLFTMMALQTITILIQMFSPSWEV 195

  Fly   243 FMLFRFLNGAALGGSGPVIWSYFAEFQPKAKR---GSMLSFMAAFWTFGNLFVASLAWLIIPRTI 304
            |....|..|.:...:..|.:...:|....|.|   ||:..||.:  ..|.:|....|:.|
Zfish   196 FSAIYFFVGFSGFSNYVVAYVLGSEILSPASRVLFGSLGVFMGS--GIGQMFFPLAAYFI----- 253

  Fly   305 GFTTPYFTYNSWRIFLLVCSLPSFLVGFLLFYLPESPKFLLTRGKKDRALAIFRGIFVTNTKRRP 369
                     .|||..:|..:|...|...|.:::||||::||::|:...|.|:.|.....|....|
Zfish   254 ---------RSWRWLVLTNALTGLLYFPLWWFIPESPRWLLSQGRTAEAEAVLRRAAEKNRVTAP 309

  Fly   370 DEYMVYDLEVDEKLLESNGNVKNKYSRMISGMVDHSRALFKSPILRFTIVSITINFTFHIGYYGL 434
             |.:....|::|      ...|......|..::.:..|:  |.||..:::.:.|.    :.||.|
Zfish   310 -EVIFSSSEIEE------AAKKRIQKHSILDILSNCNAV--STILICSLLWMVIT----MSYYAL 361

  Fly   435 LMWFPELFNRFEEYEKAFPDQSAGVCAVTDYVVNLAKEQSNNGTCSSDIPQSVFMESLISLASAL 499
            ::                                       |.|   ::..:.::...:|....:
Zfish   362 IL---------------------------------------NTT---NLHGNPYLNFFLSAVVEV 384

  Fly   500 PANLLAILGMDMLGRKFFLIAGTMTAGICSALMYFVRSSVQNLVVSAIFSG--AISAANAALDCL 562
            ||.::|.|.:....|:....:..:..|....::..:.:.:|.|..:....|  .::||...:..:
Zfish   385 PAYIIAALLLRFCSRRICQASTLLLGGALIFIIQLIPTELQGLATALEMLGKLCVTAAFCVVYAV 449

  Fly   563 ITEVFPTKLRATGVAISMVAARLGGIIGNIVIAQLLDNYCP-SPTFIVSGLLIGGGLMCLLLPNT 626
            .:|:|||.:|...:....:.||:|.||...:|  .|.||.. .|..::.||.:..|:|.||||.:
Zfish   450 TSELFPTVVRNMAMGSCSMTARIGSIISPFII--YLGNYYRYIPYIVIGGLALFSGVMSLLLPES 512

  Fly   627 TRKEL 631
            ..|.|
Zfish   513 KGKVL 517

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3168	NP_001284957.1	2A0115	149..598	CDD:273327	94/424 (22%)
CG3168	NP_001284957.1	MFS	154..623	CDD:119392	103/450 (23%)
slc22a4	NP_957143.1	2A0119	12..520	CDD:273328	108/460 (23%)
slc22a4	NP_957143.1	MFS	144..510	CDD:119392	98/438 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.940