DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3168 and Sv2c

DIOPT Version :9

Sequence 1:	NP_001284957.1	Gene:	CG3168 / 31612	FlyBaseID:	FBgn0029896	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_113781.1	Gene:	Sv2c / 29643	RGDID:	619718	Length:	727	Species:	Rattus norvegicus

Alignment Length:	680	Identity:	183/680 - (26%)
Similarity:	301/680 - (44%)	Gaps:	134/680 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    78 DNRGYEPDSHANGKQQDVE--------RDAPDGGHGG--HGPPGKGGKGGKGRKKSVPLPEPTA- 131
            |:..|.|....:|:..|.|        .|..|..:.|  .|.|..    .:|:...|.:.:|..
  Rat    55 DDDYYPPGETYSGEANDDEGSSEATEGHDEEDEIYEGEYQGIPST----NQGKDSIVSVGQPKGD 115

  Fly   132 -----------------PIVANFERAIELCGYGKFHYILLAICGLVSTSEEMDVISMSFILPSAE 179
                             .:...:|..|:.||:|:|.:.|..:.|:...::.::|..:.|:|||||
  Rat   116 EYKDRRELESERRADEEELAQQYELIIQECGHGRFQWALFFVLGMALMADGVEVFVVGFVLPSAE 180

  Fly   180 CDLDLNTETKGWLNSIIFIGMMVGAYFWGSIADSFGRKKVLIVISFMNAFCIVASSFSQTYSFFM 244
            .||.:.....|||.||:::||||||:|||.:||..|||:.|::...:|.|....|||.|.|.||:
  Rat   181 TDLCIPNSGSGWLGSIVYLGMMVGAFFWGGLADKVGRKQSLLICMSVNGFFAFLSSFVQGYGFFL 245

  Fly   245 LFRFLNGAALGGSGPVIWSYFAEFQPKAKRGSMLSFMAAFWTFGNLFVASLAWLIIPR-----TI 304
            |.|.|:|..:||:.|.::|||||...:.|||..||::..||..|.::.:::||.|||.     ::
  Rat   246 LCRLLSGFGIGGAIPTVFSYFAEVLAREKRGEHLSWLCMFWMIGGIYASAMAWAIIPHYGWSFSM 310

  Fly   305 GFTTPYFTYNSWRIFLLVCSLPSFLVGFLLFYLPESPKFLLTRGKKDRALAIFRGIFVTNTKRRP 369
            |..   :.::|||:|::||:||.......|.::||||:|||..||.|.|..|.:.|..||.:.|.
  Rat   311 GSA---YQFHSWRVFVIVCALPCVSSVVALTFMPESPRFLLEVGKHDEAWMILKLIHDTNMRARG 372

  Fly   370 DEYMVYDL-------EVDEKLLESNGNVKNKYSRM-------ISGMVDHSRALFKSPILRFTIVS 420
            ....|:.:       ::|| |:|...:....|.|.       :.|:.......|..|:...||..
  Rat   373 QPEKVFTVNKIKTPKQIDE-LIEIESDTGTWYRRCFVRIRTELYGIWLTFMRCFNYPVRENTIKL 436

  Fly   421 ITINFTFHIGYYGLLMWFPELFNRFEEYEKAFPDQSAGVCAVTDYVVNLAKE-------QSNNG- 477
            ..:.||...|||||.:|||::....:..|.|...::.......::.:|...|       :.:||
  Rat   437 TIVWFTLSFGYYGLSVWFPDVIKHLQSDEYALLTRNVQKDKYANFSINFTMENQVHTGMEYDNGR 501

  Fly   478 -----------------TCSSDIPQSV--------FMESL------------------------- 492
                             :|:.|...||        |:::|
  Rat   502 FLGVKFKSVTFKDSVFKSCTFDDVTSVNTYFKNCTFIDTLFENTDFEPYKFIDSEFQNCSFLHNK 566

  Fly   493 ---------------------ISLASALPANLLAILGMDMLGRKFFLIAGTMTAGICSALMYFVR 536
                                 :...:.||.|:::.|.||.:||...|....:.:||....::|..
  Rat   567 TGCQITFDDDYSAYWIYFVNFLGTLAVLPGNIVSALLMDRIGRLTMLGGSMVLSGISCFFLWFGT 631

  Fly   537 SSVQNLVVSAIFSGAISAANAALDCLITEVFPTKLRATGVAISMVAARLGGIIGNIVIAQLLDNY 601
            |....:.:..:::|...:|..:||.:..|::||..||||........:...::||::...|:...
  Rat   632 SESMMIGMLCLYNGLTISAWNSLDVVTVELYPTDRRATGFGFLNALCKAAAVLGNLIFGSLVSIT 696

  Fly   602 CPSPTFIVSGLLIGGGLMCLLLPNTTRKEL 631
            ...|..:.|.:|:.|||:.|.||:|..:.|
  Rat   697 KAIPILLASTVLVCGGLVGLRLPDTRTQVL 726

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3168	NP_001284957.1	2A0115	149..598	CDD:273327	152/546 (28%)
CG3168	NP_001284957.1	MFS	154..623	CDD:119392	158/566 (28%)
Sv2c	NP_113781.1	synapt_SV2	1..727	CDD:130366	183/680 (27%)
		Interaction with SYT1. /evidence=ECO:0000269\|PubMed:15866046	1..57		1/1 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	22..120		14/68 (21%)
		MFS	155..719	CDD:119392	158/567 (28%)
		Pentapeptide_3	507..561	CDD:290309	6/53 (11%)
		(Microbial infection) C.botulinum neurotoxin type A-binding. /evidence=ECO:0000269\|PubMed:16543415, ECO:0000269\|PubMed:27294781	529..566		2/36 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	166	1.000	Domainoid score	I3779
eggNOG	1	0.900	-	-		E33208_3B9V0
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	297	1.000	Inparanoid score	I2638
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D208328at33208
OrthoFinder	1	1.000	-	-		FOG0001322
OrthoInspector	1	1.000	-	-		mtm8952
orthoMCL	1	0.900	-	-		OOG6_102121
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X658
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	11	10.730