DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG3168 and Slc22a8

DIOPT Version :9

Sequence 1:	NP_001284957.1	Gene:	CG3168 / 31612	FlyBaseID:	FBgn0029896	Length:	632	Species:	Drosophila melanogaster
Sequence 2:	NP_001158106.1	Gene:	Slc22a8 / 19879	MGIID:	1336187	Length:	537	Species:	Mus musculus

Alignment Length:	551	Identity:	136/551 - (24%)
Similarity:	223/551 - (40%)	Gaps:	116/551 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 PDGGHGGHGPPGKG--------GKGGKGRK--KSVPLPEPTAPIVANFERAIELCGYGKFHYILL 154
            ||  |....||...        |..||..|  :.|.||..:.|  .:.:.|.|.|
Mouse    45 PD--HHCRPPPNASLEPWVLPLGPNGKPEKCLRFVHLPNASLP--NDTQGATEPC---------- 95

  Fly   155 AICGLVSTSEEMDVISMSFILPSAECDLDL-NTETKGWLNSIIFIGMMVGAYFWGSIADSFGRKK 218
             :.|.:..|....:::        |.||.. :.:.|....|:...|::||...:|.::|.||||.
Mouse    96 -LDGWIYNSTRDTIVT--------EWDLVCGSNKLKEMAQSVFMAGILVGGPVFGELSDRFGRKP 151

  Fly   219 VLIVISFMNAFCIVASSFSQTYSFFMLFRFLNGAALGGSGPVIWSYFAEFQPKAKRGSMLSFMAA 283
            :|.....:.|....:::||.:.:.:|:||||.|.::.|..........|:.|.:.|....:.:..
Mouse   152 ILTWSYLLLAASGSSAAFSPSLTVYMIFRFLCGCSISGISLSTIILNVEWVPTSTRAISSTTIGY 216

  Fly   284 FWTFGNLFVASLAWLIIPRTIGFTTPYFTYNSWRIFLLVCSLPSFLVGFLLFYLPESPKFLLTRG 348
            .:|.|...:..||: .:|:             ||...|..|...|:...|.:::|||.::|:..|
Mouse   217 CYTIGQFILPGLAY-AVPQ-------------WRWLQLSVSAAFFIFSLLSWWVPESIRWLVLSG 267

  Fly   349 KKDRALAIFRGIFVTNTKRRPDEYMVYDLEVDEKLLESNGNVKNKYSRMISGMVDHSRALFKSPI 413
            |..:||...:.:...|.|:...|.:..: |:...|.:...:.|.||     |:.|    ||:..|
Mouse   268 KFSKALKTLQRVATFNGKKEEGEKLTVE-ELKFNLQKDITSAKVKY-----GLSD----LFRVSI 322

  Fly   414 LRFTIVSITIN-FTFHIGYYGLLMWFPELFNRFEEYEKAFPDQSAGVCAVTDYVVNLAKEQSNNG 477
            ||.....:::. |.....||.|.|                        .|.::.||
Mouse   323 LRRVTFCLSLAWFATGFAYYSLAM------------------------GVEEFGVN--------- 354

  Fly   478 TCSSDIPQSVFMESLISLASALPANLLAILGMDMLGRKF---FLIAGTMTAGICSALMYFVRSSV 539
                     :::..:|.....:||..:.||.:..|||:.   ||:   :.||:....:.||.|.:
Mouse   355 ---------IYILQIIFGGVDIPAKFITILSISYLGRRITQGFLL---ILAGVAILALIFVSSEM 407

  Fly   540 QNL-VVSAIF-SGAISAANAALDCLITEVFPTKLRATGVAISMVAARLGGIIGNIV-IAQLLDNY 601
            |.| ...|:| .|.:|.:.:.|....:|::||.||.||:.||.:.||:|.:|..:| |...|..:
Mouse   408 QLLRTALAVFGKGCLSGSFSCLFLYTSELYPTVLRQTGMGISNIWARVGSMIAPLVKITGELQPF 472

  Fly   602 CPSPTFIVSGLLIGGGLMCLL------LPNT 626
            .|:..|....||.|.....||      ||.|
Mouse   473 IPNVIFGTMTLLGGSAAFFLLETLNRPLPET 503

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3168	NP_001284957.1	2A0115	149..598	CDD:273327	109/456 (24%)
CG3168	NP_001284957.1	MFS	154..623	CDD:119392	117/482 (24%)
Slc22a8	NP_001158106.1	2A0119	11..503	CDD:273328	135/549 (25%)
Slc22a8	NP_001158106.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	513..537
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1933
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.940